Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Simeon S. Andrews"'
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Akademický článek
Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes
Autor: Thasni Karedath, Ikhlak Ahmed, Wafa Al Ameri, Fatima M. Al-Dasim, Simeon S. Andrews, Samson Samuel, Iman K. Al-Azwani, Yasmin Ali Mohamoud, Arash Rafii, Joel A. Malek
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background Circular RNAs (circRNAs) that form through non-canonical backsplicing events of pre-mRNA transcripts are evolutionarily conserved and abundantly expressed across species. However, the functional relevance of circRNAs remains a top
Externí odkaz: https://doaj.org/article/49ecec08064b48a4854176c6123b5d34
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2
High-resolution protein–protein interaction mapping using all-versus-all sequencing (AVA-Seq)
Autor: Simeon S. Andrews, Ikhlak Ahmed, Stephanie Schaefer-Ramadan, Joel A. Malek, Yasmin A. Mohamoud, Nayra M Al-Thani
Publikováno v: Journal of Biological Chemistry. 294:11549-11558
Two-hybrid systems can be used for investigating protein-protein interactions and may provide important information about gene products with unknown function. Despite their success in mapping protein interactions, two-hybrid systems have remained mos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f69b2983b6679481246476e6e9af4f40
https://doi.org/10.1074/jbc.ra119.008792
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3
Regulation of Circular RNA CircNFATC3 in Cancer Cells Alters Proliferation, Migration, and Oxidative Phosphorylation
Autor: Fatima M. Al-Dasim, Ikhlak Ahmed, Said Dermime, Thasni Karedath, Yasmin A. Mohamoud, Joel A. Malek, Afsheen Raza, Albandary Al-Qurashi, Ayeda A. Ahmed, Simeon S. Andrews
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Circular RNAs were once considered artifacts of transcriptome sequencing but have recently been identified as functionally relevant in multiple cancers. Although there is still no clear main function of circRNAs, several studies have revealed that ci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2200e7be4add64d151410b3dc3bf4c7
https://www.frontiersin.org/articles/10.3389/fcell.2021.595156/full
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4
High resolution protein-protein interaction mapping using all-versus-all sequencing (AVA-seq)
Autor: Ikhlak Ahmed, Simeon S. Andrews, Stephanie Ramadan, Yasmin A. Mohamoud, Nayra M Al-Thani, Joel A. Malek
Two-hybrid systems test for protein-protein interactions and can provide important information for genes with unknown function. Despite their success, two-hybrid systems have remained mostly untouched by improvements from next-generation DNA sequenci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ac2a5bc4501ad058752ee3c2d5e3b4
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5
Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes
Autor: Wafa Al Ameri, Arash Rafii, Joel A. Malek, Yasmin Ali Mohamoud, Simeon S. Andrews, Fatima M. Al-Dasim, Thasni Karedath, Samson Mathews Samuel, Ikhlak Ahmed, Iman K. Al-Azwani
Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-17 (2019)
BMC Cancer
Background Circular RNAs (circRNAs) that form through non-canonical backsplicing events of pre-mRNA transcripts are evolutionarily conserved and abundantly expressed across species. However, the functional relevance of circRNAs remains a topic of deb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43ece516605ccf8d76ff2752642b199
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8
Label Transfer Reagents to Probe p38 MAPK Binding Partners
Autor: B. Gayani K. Perera, Simeon S. Andrews, Dustin J. Maly, Z.B. Hill
Publikováno v: ChemBioChem. 14:209-216
Protein kinases are essential enzymes for cellular signalling, and are often regulated by participation in protein complexes. The mitogen-activated protein kinase (MAPK) p38 is involved in multiple pathways, and its regulation depends on its interact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bdef981f3cac111c3d4486be6bab2a
https://doi.org/10.1002/cbic.201200673
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9
High-Throughput Discovery of Cancer Cell Surface Interactions by Pairing cDNA Phage Display and Next Generation Sequencing
Autor: Simeon S. Andrews, Joel A. Malek
Publikováno v: Qatar Foundation Annual Research Conference Proceedings Volume 2016 Issue 1.
Determining the complement of binding partners for a given protein is one of the most common questions in the field of biochemistry. Understanding complex protein interaction networks enables predictions about putative drug targets and the effects of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbfbae70e3cfa28732bdc40058912f18
https://doi.org/10.5339/qfarc.2016.hbpp1636
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10
Targeting Diverse Signaling Interaction Sites Allows the Rapid Generation of Bivalent Kinase Inhibitors
Autor: B. Gayani K. Perera, Z.B. Hill, Simeon S. Andrews, Dustin J. Maly
Publikováno v: ACS Chemical Biology. 7:487-495
The identification of potent and selective modulators of protein kinase function remains a challenge, and new strategies are needed for generating these useful ligands. Here, we describe the generation of bivalent inhibitors of three unrelated protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3aebd202bacc40eed7504293b70dab1
https://doi.org/10.1021/cb200387g
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