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Autor:
Sandra Braun, Michael Röring, Campbell McInnes, Simeon Galda, Tilman Brummer, Chad M Beneker, Magdalini Rovoli, George Kontopidis
Publikováno v:
Journal of Medicinal Chemistry. 62:3886-3897
Despite the clinical success of BRAF inhibitors like vemurafenib in treating metastatic melanoma, resistance has emerged through "paradoxical MEK/ERK signaling" where transactivation of one protomer occurs as a result of drug inhibition of the other