Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Simeon E. Goldblum"'
Autor:
Erik P. Lillehoj, Yafan Yu, Avelino C. Verceles, Akihiro Imamura, Hideharu Ishida, Kurt H. Piepenbrink, Simeon E. Goldblum
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110866- (2024)
Summary: Stenotrophomonas maltophilia (Sm), a multidrug-resistant pathogen often isolated from immunocompromised individuals, presents its flagellin to multimeric tandem repeats within the ectodomain of mucin-1 (MUC1-ED), expressed on airway epitheli
Externí odkaz:
https://doaj.org/article/321142e490cf4f108f71724009877c4d
Autor:
Sang W. Hyun, Chiguang Feng, Anguo Liu, Erik P. Lillehoj, Rossana Trotta, Tami J. Kingsbury, Antonino Passaniti, Katerina N. Lugkey, Sitara Chauhan, John F. Cipollo, Irina G. Luzina, Sergei P. Atamas, Alan S. Cross, Simeon E. Goldblum
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-23 (2022)
Abstract To gain insight into sialic acid biology and sialidase/neuraminidase (NEU) expression in mature human neutrophil (PMN)s, we studied NEU activity and expression in PMNs and the HL60 promyelocytic leukemic cell line, and changes that might occ
Externí odkaz:
https://doaj.org/article/289ac30cc0a342a584ab79a26dfc59e5
Autor:
Avelino C. Verceles, Pavan Bhat, Zain Nagaria, Destiny Martin, Harsh Patel, Afua Ntem-Mensah, Sang W. Hyun, Andrea Hahn, Jean Jeudy, Alan S. Cross, Erik P. Lillehoj, Simeon E. Goldblum
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo. Here, we asked whether Pa in the lungs of p
Externí odkaz:
https://doaj.org/article/4e92ed863fcf4e86a43cdd61abc11314
Autor:
Chiguang Feng, Jihong Li, Greg Snyder, Wei Huang, Simeon E. Goldblum, Wilbur H. Chen, Lai-Xi Wang, Bruce A. McClane, Alan S. Cross
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Neuraminidases (NAs) are critical virulence factors for several microbial pathogens. With a highly conserved catalytic domain, a microbial NA “superfamily” has been proposed. We previously reported that murine polymorphonuclear leukocyte
Externí odkaz:
https://doaj.org/article/9d44252f5a7942d984e932742a4172a9
Autor:
Tonya J. Webb, Jonathan P. Schneck, Mathias Oelke, Robert L. Giuntoli, Simeon E. Goldblum, Sarah Spiegel, Sarah M. Temkin, Irina V. Tiper
The source of GD3 impacts CD1d-mediated antigen presentation.(A) LCD1d cells were treated with GD3 from different sources for 4 hours, then washed extensively and cocultured with NKT cell hybridomas. IL-2 was measured, as an indication of NKT cell ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799e58147807faa82cbcc2187827ae44
https://doi.org/10.1158/1078-0432.22455872.v1
https://doi.org/10.1158/1078-0432.22455872.v1
Autor:
Tonya J. Webb, Jonathan P. Schneck, Mathias Oelke, Robert L. Giuntoli, Simeon E. Goldblum, Sarah Spiegel, Sarah M. Temkin, Irina V. Tiper
Ovarian cancer associated ascites contains soluble inhibitory factors. The ascites was cleared of cellular debris by centrifugation as previously described (18). (A, B) The ascites was filtered 0.2 micron filter and fractionated- f1: 50. (C) The asci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280df69edd902461d357cb0ed0f9abe5
https://doi.org/10.1158/1078-0432.22455875.v1
https://doi.org/10.1158/1078-0432.22455875.v1
Autor:
Irina G. Luzina, Akihiro Imamura, Erik P. Lillehoj, Christopher W. Cairo, Simeon E. Goldblum, Sang W. Hyun, Katerina N. Lugkey, Virginia Lockatell, Hideharu Ishida, Sergei P. Atamas
Publikováno v:
J Pharmacol Exp Ther
Pulmonary fibrosis remains a serious biomedical problem with no cure and an urgent need for better therapies. Neuraminidases (NEUs), including NEU1, have been recently implicated in the mechanism of pulmonary fibrosis by us and others. We now have te
Autor:
Sang W. Hyun, Chiguang Feng, Anguo Liu, Erik P. Lillehoj, Rossana Trotta, Tami J. Kingsbury, Antonino Passaniti, Katerina N. Lugkey, Sitara Chauhan, John F. Cipollo, Irina G. Luzina, Sergei P. Atamas, Alan S. Cross, Simeon E. Goldblum
Publikováno v:
Scientific reports. 12(1)
To gain insight into sialic acid biology and sialidase/neuraminidase (NEU) expression in mature human neutrophil (PMN)s, we studied NEU activity and expression in PMNs and the HL60 promyelocytic leukemic cell line, and changes that might occur in PMN
Autor:
Destiny Martin, Sang W. Hyun, Afua Ntem-Mensah, Erik P. Lillehoj, Pavan Bhat, Avelino C. Verceles, Simeon E. Goldblum, Harsh Patel, Zain Nagaria, Andrea Hahn, Alan S. Cross, Jean Jeudy
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo. Here, we asked whether Pa in the lungs of patients w
Autor:
Sang W. Hyun, Hideharu Ishida, Akihiro Imamura, Simeon E. Goldblum, Erik P. Lillehoj, Kurt H. Piepenbrink
Publikováno v:
The Journal of Biological Chemistry
The extracellular domain (ED) of the membrane-spanning sialoglycoprotein, mucin-1 (MUC1), is an in vivo substrate for the lysosomal sialidase, neuraminidase-1 (NEU1). Engagement of the MUC1-ED by its cognate ligand, Pseudomonas aeruginosa-expressed f