Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Simendra Singh"'
Autor:
Simendra Singh
Publikováno v:
Cancer Chemotherapy and Pharmacology. 75:1-15
Glutathione S-transferases (GSTs) family of enzymes is best known for their cytoprotective role and their involvement in the development of anticancer drug resistance. Recently, emergence of non-detoxifying properties of GSTs has provided them with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7768de66acacc4ac4521d1f468c81a6
https://doi.org/10.1007/s00280-014-2566-x
https://doi.org/10.1007/s00280-014-2566-x
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 40:45-51
Glutathione S-transferases (GSTs) play an important role in the biotransformation of endogenous compounds and xenobiotics as well as in the metabolic inactivation of pharmacologically active substances, including anticancer drugs. Using cisplatin as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd683f3e26ec826ce1402b0c13075e78
https://doi.org/10.1007/s13318-014-0176-y
https://doi.org/10.1007/s13318-014-0176-y
Publikováno v:
Biochemical Pharmacology. 80:1343-1355
Recently, we reported that the human GSTP1 is phosphorylated and functionally activated by the PKC class of serine/threonine kinases. In this study, we investigated the contribution of this post-translational modification of GSTP1 to tumor cisplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fb83ffaf420feb7cb6bb61a671a871
https://doi.org/10.1016/j.bcp.2010.07.019
https://doi.org/10.1016/j.bcp.2010.07.019
Publikováno v:
Molecular Cancer Therapeutics. 8:1261-1269
Tumor-associated macrophages (TAMs) are found in many solid tumors and have often been shown to accumulate in the hypoxic regions surrounding areas of necrosis. TAMs are the major site of expression of nitric oxide synthase (NOS), a heme-containing h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40180dea7790a1351c58bef0c3c3830a
https://doi.org/10.1158/1535-7163.mct-08-0927
https://doi.org/10.1158/1535-7163.mct-08-0927
Publikováno v:
Radiation Research. 171:572-580
Nitric oxide (NO) is a potent radiosensitizer of hypoxic mammalian cells. There have been many reports demonstrating radiosensitization in vitro and in vivo by the use of NO donors to generate NO by chemical means or by producing agents that mimic th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6466bef70eee8f8fdd9ee848e607f610
https://doi.org/10.1667/rr1640.1
https://doi.org/10.1667/rr1640.1
Publikováno v:
Journal of experimental therapeuticsoncology. 9(4)
Glutathione (GSH) is an important intracellular antioxidant that instills several vital roles within a cell including maintenance of the redox state, drug detoxification, and cellular protection from damage by free radicals, peroxides and toxins. Mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b57e53ddaca47b5c523b1cf4e03806de
https://pubmed.ncbi.nlm.nih.gov/22545423
https://pubmed.ncbi.nlm.nih.gov/22545423
Autor:
Simendra Singh, Alok Gupta
Publikováno v:
Cancer chemotherapy and pharmacology. 67(6)
The diatomic radical nitric oxide (NO) has been the cause of intense debate with implication in carcinogenesis, tumour progression, invasion, angiogenesis and modulation of therapeutic responses. The tumour biology of NO is highly complex, and this r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c879c72b46785ee790a1610dbc954aa0
https://pubmed.ncbi.nlm.nih.gov/21544630
https://pubmed.ncbi.nlm.nih.gov/21544630
Autor:
Timothy A.J. Haystead, Tatsunori Okamura, Simendra Singh, John K. Buolamwini, Francis Ali-Osman, Darell D. Bigner, Henry S. Friedman
Publikováno v:
The Journal of biological chemistry. 284(25)
Epidermal growth factor receptor (EGFR) gene amplification, mutations, and/or aberrant activation are frequent abnormalities in malignant gliomas and other human cancers and have been associated with an aggressive clinical course and a poor therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aca3cc073169fbd6e538f65d88b0ff0
https://pubmed.ncbi.nlm.nih.gov/19254954
https://pubmed.ncbi.nlm.nih.gov/19254954
Publikováno v:
Biotech Today : An International Journal of Biological Sciences. 4:22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aea657f50722c8f6828136a5d93e5e6
https://doi.org/10.5958/2322-0996.2014.00023.4
https://doi.org/10.5958/2322-0996.2014.00023.4
Autor:
Simendra Singh, Francis Ali-Osman
Publikováno v:
Cancer Research. 70:2557-2557
Temozolomide (TMZ) is a methylating agent used in first-line treatment of malignant gliomas and melanomas. Unfortunately, its use is limited by multifaceted resistance mechanisms. Although, the glutathione S-transferase P1 (GSTP1) protein metabolizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc0319a6e6aaaca70b534bc35bcb1353
https://doi.org/10.1158/1538-7445.am10-2557
https://doi.org/10.1158/1538-7445.am10-2557