Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Simarjit Kaur Singhrao"'
Autor:
Flavio, Pisani, Valerio, Pisani, Francesca, Arcangeli, Alice, Harding, Simarjit Kaur, Singhrao
Publikováno v:
International journal of environmental research and public health. 19(15)
Alzheimer's Disease (AD) is a complex neurodegenerative disease and remains the most common form of dementia. The pathological features include amyloid (Aβ) accumulation, neurofibrillary tangles (NFTs), neural and synaptic loss, microglial cell acti
Publikováno v:
Journal of Alzheimer's Disease Reports
Porphyromonas gingivalis (P. gingivalis) is one of the several important bacterial pathogens associated with the sporadic Alzheimer’s disease (AD). Different serotypes are either capsulated or are non-capsulated. It has been demonstrated that P. gi
Autor:
Simarjit Kaur Singhrao, Alice Harding
Publikováno v:
J Dent Res
Dementia and Alzheimer’s disease (AD) are proposed to be comorbid with periodontitis (PD). It is unclear whether PD is associated with dementia and AD independent of confounding factors. We aimed at identifying the relationship between the longitud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a274d93e18b0485ed21935188179a8
Autor:
Alaa A. A. Aljabali, Sasanka S. Chukkapalli, Bojlul Bahar, Saeid Doaei, Richard Welbury, Simarjit Kaur Singhrao, Shalini Kanagasingam, Murtaza M. Tambuwala, Stephanie Dillon
Publikováno v:
Journal of Alzheimer's disease : JAD. 82(3)
Background: Periodontal disease(s) and metabolic illnesses negatively impact the quality of life and, eventually mental health. Objective: This study investigated the effect of Porphyromonas gingivalis (W83) oral infection on the development of Alzhe
Autor:
Bojlul Bahar, Simarjit Kaur Singhrao
Publikováno v:
Molecular Biology Reports
Porphyromonas gingivalis triggers a range of innate immune responses in the host that may contribute to the development of periodontitis and dementing diseases including Alzheimer’s disease (AD). This study aimed to assess the mode of action of tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f6cd4c4a52167c42a40dfe83d2012c
Autor:
Simarjit Kaur Singhrao, Alice Harding
The question of whether Alzheimer’s disease (AD) is an infectious condition has been proposed previously but, received little support. This appears mainly due to an inability of being able to satis...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878e4a4eb37d0a05bf9c5fc797a434c9
Autor:
Ingar Olsen, Simarjit Kaur Singhrao
Publikováno v:
Journal of Oral Microbiology, Vol 12, Iss 1 (2020)
Journal of Oral Microbiology
Journal of Oral Microbiology
In late-onset Alzheimer disease (AD) pathogenesis, genes, infections and immunity could be significant factors. We have reviewed if the keystone periodontal pathogen Porphyromonas gingivalis may affect genes and microglia (primary immune cells in the
Autor:
Simarjit Kaur Singhrao, Ingar Olsen
The microbiota of “chronic” periodontitis, particularly Porphyromonas gingivalis, have been implicated in Alzheimer’s disease (AD) because this bacterium has a range of enzymes (cathepsin B and gingipains) that are shown to interact with the am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57602a6080ea6eb0966c87092e9aaf29
Autor:
Ingar Olsen, Simarjit Kaur Singhrao
Publikováno v:
Journal of Oral Microbiology
Journal of Oral Microbiology, Vol 12, Iss 1 (2020)
Journal of Oral Microbiology, Vol 12, Iss 1 (2020)
Defects, as determined by Genome-Wide Association Studies (GWAS), in the complement cascade of innate immunity have been suggested to play a key role in Alzheimer’s disease (AD). These defective genes encode complement sub-component 1s (C1s), compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67fe6dab01a24e3ae721b45e521b1ce
Autor:
St John Crean, Lakshmyya Kesavalu, Sasanka S. Chukkapalli, Simarjit Kaur Singhrao, Farheen Rokad, Ryan Moseley, Rowan Hardy
Publikováno v:
Journal of Alzheimer's Disease. 60:359-369
The polymicrobial dysbiotic subgingival biofilm microbes associated with periodontal disease appear to contribute to developing pathologies in distal body sites, including the brain. This study examined oxidative stress, in the form of increased prot