Zobrazeno 1 - 10
of 11 528
pro vyhledávání: '"Simak"'
Autor:
Tommaso De Marchi, Chun-Fui Lai, Georgia M. Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H. Saal, Johan Malmström, Simak Ali, Emma Niméus
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic
Externí odkaz:
https://doaj.org/article/d1192d9df9934484a96a115d8dfd7398
Autor:
Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H. B. Kroll, Marion Barbazanges, Bodo Scheiper, Ash K. Bahl, Anthony G. M. Barrett, Simak Ali, Abhay Kotecha, Basil J. Greber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Rational design of next-generation therapeutics can be facilitated by high-resolution structures of drug targets bound to small-molecule inhibitors. However, application of structure-based methods to macromolecules refractory to crystallizat
Externí odkaz:
https://doaj.org/article/a393bf7c13c14f7a93881e19f56dabfa
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Samuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with advanced malignancies was designed (ClinicalTrials.gov: NCT03363893). Here we rep
Externí odkaz:
https://doaj.org/article/b14be29b81754bafad04d4aa37714251
Autor:
Patrick Aouad, Yueyun Zhang, Fabio De Martino, Céline Stibolt, Simak Ali, Giovanna Ambrosini, Sendurai A. Mani, Kelly Maggs, Hazel M. Quinn, George Sflomos, Cathrin Brisken
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The study of tumour dormancy is limited by suitable in vivo models. Here the authors show that mammary intraductal breast cancer (BC) xenografts model estrogen receptor α-positive (ER+) BC dormancy and rapid metastatic progression characteristic of
Externí odkaz:
https://doaj.org/article/e64c8d7c36a048a5972caf859a65088a
Autor:
Zheqi Li, Olivia McGinn, Yang Wu, Amir Bahreini, Nolan M. Priedigkeit, Kai Ding, Sayali Onkar, Caleb Lampenfeld, Carol A. Sartorius, Lori Miller, Margaret Rosenzweig, Ofir Cohen, Nikhil Wagle, Jennifer K. Richer, William J. Muller, Laki Buluwela, Simak Ali, Tullia C. Bruno, Dario A. A. Vignali, Yusi Fang, Li Zhu, George C. Tseng, Jason Gertz, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Mutations of ESR1, the gene encoding the estrogen receptor alpha, are associated with acquired resistance to therapy in luminalbreast cancer. Here the authors show that ESR1 mutant tumors gain basal-like features with increased expression of basal cy
Externí odkaz:
https://doaj.org/article/3ce70acd6e2e4c66a89d08122c1ec702
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4ff05e79a58f49b980db63215fe0a4b3
Autor:
Athina Giannoudis, Mohammed Imad Malki, Bharath Rudraraju, Hisham Mohhamed, Suraj Menon, Triantafillos Liloglou, Simak Ali, Jason S. Carroll, Carlo Palmieri
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-17 (2020)
Abstract Background Activating transcription factor-2 (ATF2), a member of the leucine zipper family of DNA binding proteins, has been implicated as a tumour suppressor in breast cancer. However, its exact role in breast cancer endocrine resistance is
Externí odkaz:
https://doaj.org/article/c7c81c505b3d46d19b1b4273f72eb36a
Publikováno v:
E3S Web of Conferences, Vol 381, p 02007 (2023)
The article reveals the main directions of digital transformation of business processes in the logistics activities of transport enterprises to improve information exchange between production, wholesale and retail trading enterprises. The competitive
Externí odkaz:
https://doaj.org/article/b0ca28b59e48477c823e0bcd9f83423c
Autor:
Hajnalka L Pálinkás, Angéla Békési, Gergely Róna, Lőrinc Pongor, Gábor Papp, Gergely Tihanyi, Eszter Holub, Ádám Póti, Carolina Gemma, Simak Ali, Michael J Morten, Eli Rothenberg, Michele Pagano, Dávid Szűts, Balázs Győrffy, Beáta G Vértessy
Publikováno v:
eLife, Vol 9 (2020)
Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we
Externí odkaz:
https://doaj.org/article/cf7a1b9f9d9c42cda6d001319a1a4ee2
Autor:
James W. Hindley, Yuval Elani, Catriona M. McGilvery, Simak Ali, Charlotte L. Bevan, Robert V. Law, Oscar Ces
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Matryoshka doll-like, nested vesicles, each containing a different ingredient to a chemical reaction, can serve as microreactors. Here, the authors developed a system in which mixing of the ingredients can be induced by irradiation with ultraviolet l
Externí odkaz:
https://doaj.org/article/70757d22ec7b4fbd9828bd4dc7607b93