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pro vyhledávání: '"SimCyp®"'
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Akademický článek
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Autor:
Rania Elkeeb, Anomeh Avartoomian, Amira S. Gouda, Ahmed M. Abdel-Megied, Ola Abdallah, Eman Atef
Publikováno v:
Scientia Pharmaceutica, Vol 91, Iss 3, p 38 (2023)
The aim of the study is to evaluate the effectiveness of the pediatric sofosbuvir weight-based dosing strategy in providing an equitable drug exposure compared to the marketed dose. The physiologically based pharmacokinetic (PBPK) modeling and simula
Externí odkaz:
https://doaj.org/article/0222117e208a4031bdb2e1edcebf0c4a
Autor:
Hiba Khalidi, Anthonia Onasanwo, Barira Islam, Heeseung Jo, Ciarán Fisher, Rich Aidley, Iain Gardner, Frederic Y. Bois
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
SimRFlow is a high-throughput physiologically based pharmacokinetic (PBPK) modelling tool which uses Certara’s Simcyp® simulator. The workflow is comprised of three main modules: 1) a Data Collection module for automated curation of physicochemica
Externí odkaz:
https://doaj.org/article/05e627da92eb40dba6a8e07ee9f1ec40
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1040 (2023)
Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO). The absorption of albendazole is limited by poor aqueous solubility, an
Externí odkaz:
https://doaj.org/article/ff31cbb4e7bb495f88c9712a9ebf3a21
Autor:
Konstantinos Stamatopoulos, Connor O’Farrell, Mark J. H. Simmons, Hannah K. Batchelor, Nena Mistry
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 882 (2023)
A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus® 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrat
Externí odkaz:
https://doaj.org/article/971020ba2e1c4f99a5d83f9bf2223142
Autor:
Caroline Sychterz, Iain Gardner, Manting Chiang, Ramakrishna Rachumallu, Sibylle Neuhoff, Vidya Perera, Samira Merali, Brian J. Schmidt, Lu Gaohua
Publikováno v:
Metabolites, Vol 12, Iss 10, p 1001 (2022)
Physiologically based pharmacokinetic (PBPK) modeling has a number of applications, including assessing drug–drug interactions (DDIs) in polymorphic populations, and should be iteratively refined as science progresses. The Simcyp Simulator is annua
Externí odkaz:
https://doaj.org/article/7fd1513fad8a4539b077960c88a087e4
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 541 (2022)
Doxorubicin (DOX) is still an important anticancer agent despite its tricky pharmacokinetics (PK) and toxicity potential. The advent of systems pharmacology enables the construction of PK models able to predict the concentration profiles of drugs and
Externí odkaz:
https://doaj.org/article/3fc0c50608194d64a4182565cdd84a3a
Autor:
Sundus Khalid, Muhammad Fawad Rasool, Imran Imran, Abdul Majeed, Hamid Saeed, Anees ur Rehman, Waseem Ashraf, Tanveer Ahmad, Yousef A. Bin Jardan, Faleh Alqahtani
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1480 (2021)
Diazepam is one of the most prescribed anxiolytic and anticonvulsant that is administered through intravenous (IV), oral, intramuscular, intranasal, and rectal routes. To facilitate the clinical use of diazepam, there is a need to develop formulation
Externí odkaz:
https://doaj.org/article/097e78cf75ff4c22a41c673e87a77c81
Autor:
Konstantinos Stamatopoulos, Paola Ferrini, Dung Nguyen, Ying Zhang, James M. Butler, Jon Hall, Nena Mistry
Publikováno v:
Pharmaceutics
Volume 15
Issue 2
Pages: 521
Volume 15
Issue 2
Pages: 521
A strategy followed to integrate in vitro solubility and permeability data into a PBBM model to predict the food effect of a BCS IV zwitterionic drug (GSK3640254) observed in clinical studies is described. The PBBM model was developed, qualified and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4406e9320b5177357bce4df70d4a2f8e