Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Sim Winitz"'
1
The Regulation of Growth and Intracellular Signaling by Integrins
Autor: Mark W. Renshaw, Sim Winitz, Martin A. Schwartz, Sibylle Hess, Jere E. Meredith, Xiang-Dong Ren, Jean M. Lewis
Publikováno v: Endocrine Reviews. 17:207-220
I. Introduction INTEGRINS are a family of more than 20 different transmembrane receptors composed of noncovalently associated α- and β-subunit heterodimers (1). Twelve different α-subunits, each approximately 1000 residues in length, and eight dif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84c589e49c474d7d153b344a5d74514
https://doi.org/10.1210/edrv-17-3-207
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2
How does the G protein, Gi2, transduce mitogenic signals?
Autor: Sim Winitz, Carol A. Lange-Carter, Anne M. Gardner, Gary L. Johnson, Marijane Russell, Nan‐Xin ‐X Qian
Publikováno v: Journal of Cellular Biochemistry. 54:415-422
Serpentine receptors coupled to the heterotrimeric G protein, Gi2, are capable of stimulating DNA synthesis in a variety of cell types. A common feature of the Gi2-coupled stimulation of DNA synthesis is the activation of the mitogen-activated protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d38531da81f9876e88d0ad5e1b904c
https://doi.org/10.1002/jcb.240540408
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3
Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity
Autor: Gary L. Johnson, Sim Winitz, Marijane Russell
Publikováno v: Molecular and Cellular Biology. 14:2343-2351
Acetylcholine muscarinic m2 receptors (m2R) couple to heterotrimeric Gi proteins and activate the Ras/Raf/mitogen-activated protein kinase pathway and phosphatidylinositol 3-kinase in Rat 1a cells. In contrast to the m2R, stimulation of the acetylcho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e408f10d146164870e08bccde9c5f4
https://doi.org/10.1128/mcb.14.4.2343
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4
Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation
Autor: Sunil Gupta, Lynn E. Heasley, Sim Winitz, Raphael A. Nemenoff, Gary L. Johnson, Nan Xin Qian
Publikováno v: Journal of Biological Chemistry. 269:1889-1895
The 85-kDa cytoplasmic phospholipase A2 (cPLA2) is the major hormone and growth factor-regulated enzyme that catalyzes release of arachidonic acid in mammalian cells. Activation of cPLA2 requires elevation of intracellular Ca2+ and the phosphorylatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db9576635172ccac6e7faaa9a5489fbe
https://doi.org/10.1016/s0021-9258(17)42110-7
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5
Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase
Autor: Gary L. Johnson, Marijane Russell, Nan-Xin Qian, Anne M. Gardner, Sim Winitz, L. Dwyer
Publikováno v: Journal of Biological Chemistry. 268:19196-19199
Stimulation of the acetylcholine muscarinic m2 receptor (m2R) expressed in Rat 1a fibroblasts results in the activation of the cytoplasmic mitogen-activated protein kinase (MAPK). Concomitant with carbachol stimulation of the m2R was the activation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8eee555b5e9f8378adbf1f78a504e52
https://doi.org/10.1016/s0021-9258(19)36498-1
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7
Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C
Autor: Sim Winitz, Lynn E. Heasley, Nan Xin Qian, Gary L. Johnson, Vicki Van Putten, Raphael A. Nemenoff
Publikováno v: Journal of Biological Chemistry. 268:1960-1964
Phospholipase A2 (PLA2) is the enzyme regulating the release of arachidonic acid in most cell types. A high molecular mass, 85-kDa soluble form of PLA2 (cPLA2) has recently been identified, the activity of which is stably increased by stimulation of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1be6fb7e40e813b42cf7f90e21636e5
https://doi.org/10.1016/s0021-9258(18)53948-x
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8
Myristoylation of the G alpha i2 polypeptide, a G protein alpha subunit, is required for its signaling and transformation functions
Autor: Bartholomew J. Eisfelder, Gary L. Johnson, Carme Gallego, Sim Winitz, Sunil Gupta
Publikováno v: Proceedings of the National Academy of Sciences. 89:9695-9699
GTPase-inhibiting mutations of the alpha subunit (alpha i2) of the G protein, Gi2, result in constitutive activation of alpha i2 signal transduction functions. GTPase-inhibited alpha i2 mutant polypeptides, referred to as gip2 oncoproteins, have glut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef81369b22166eb51856f3d8b614e85a
https://doi.org/10.1073/pnas.89.20.9695
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9
[25] Construction of mutant and chimeric G-protein α subunits
Autor: Marijane Russell, Gary L. Johnson, Sim Winitz
Publisher Summary Among the G-protein α subunits there are both common and unique functions encoded in the structure of the α -chain polypeptide. Common features include the functions involved in regulation of the α subunit itself: (1) guanosine-d
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https://doi.org/10.1016/s0076-6879(94)37072-9
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10
Epitope-tagged Gq alpha subunits: expression of GTPase-deficient alpha subunits persistently stimulates phosphatidylinositol-specific phospholipase C but not mitogen-activated protein kinase activity regulated by the M1 muscarinic acetylcholine receptor
Autor: Sim Winitz, Gary L. Johnson, Nan Xin Qian
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 90(9)
Gq is the heterotrimeric guanine nucleotide-binding protein that activates the beta isoforms of phosphatidyl-inositol-specific phospholipase C (PI-PLC). The Gq alpha-subunit polypeptide (alpha qa) was N-terminally modified by addition of a 9-aa seque
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a8d36c6063e946e234c0c715298dd8
https://pubmed.ncbi.nlm.nih.gov/7683419
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