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A Randomized Phase 2 Trial of Nivolumab Versus Nivolumab-Ipilimumab Combination in EGFR-Mutant NSCLC.

Autor: Lai GGY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Yeo JC; Genome Institute of Singapore, Singapore., Jain A; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Zhou S; Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, Singapore., Pang M; Genome Institute of Singapore, Singapore., Alvarez JJS; Genome Institute of Singapore, Singapore., Sim NL; Genome Institute of Singapore, Singapore., Tan AC; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Suteja L; Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore., Lim TW; Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, Singapore., Guo YA; Genome Institute of Singapore, Singapore., Shen M; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Saw SPL; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Rohatgi N; Genome Institute of Singapore, Singapore., Yeong JPS; Institute of Molecular and Cell Biology, Singapore., Takano A; Division of Pathology, Singapore General Hospital, Singapore., Lim KH; Division of Pathology, Singapore General Hospital, Singapore., Gogna A; Department of Vascular and Interventional Radiology, Singapore General Hospital, Singapore., Too CW; Department of Vascular and Interventional Radiology, Singapore General Hospital, Singapore., Da Zhuang K; Department of Vascular and Interventional Radiology, Singapore General Hospital, Singapore., Tan WL; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Kanesvaran R; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Ng QS; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Ang MK; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Rajasekaran T; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Wang L; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Toh CK; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Lim WT; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Tam WL; Genome Institute of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Tan SH; Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, Singapore., Skanderup AMJ; Genome Institute of Singapore, Singapore., Tan EH; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Tan DSW; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.

Publikováno v: JTO clinical and research reports [JTO Clin Res Rep] 2022 Sep 21; Vol. 3 (12), pp. 100416. Date of Electronic Publication: 2022 Sep 21 (Print Publication: 2022).

Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer.

Autor: Sheng T; Department of Biochemistry, National University of Singapore, Singapore, 117596, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore., Ho SWT; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Ooi WF; Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, 138672, Singapore., Xu C; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Xing M; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore.; Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, 138672, Singapore., Padmanabhan N; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore., Ma L; The Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA., Ray M; The Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA., Guo YA; Precision Medicine and Population Genomics (Somatic), Genome Institute of Singapore, Singapore, 138672, Singapore., Sim NL; Precision Medicine and Population Genomics (Somatic), Genome Institute of Singapore, Singapore, 138672, Singapore., Anene-Nzelu CG; Cardiovascular Research Institute, National University Health System, Singapore, 119074, Singapore.; Precision Medicine and Population Genomics (Germline), Genome Institute of Singapore, Singapore, Singapore.; Montreal Heart Institute, Montreal, Canada.; Department of Medicine, University of Montreal, Montreal, Canada., Chang MM; Precision Medicine and Population Genomics (Somatic), Genome Institute of Singapore, Singapore, 138672, Singapore., Razavi-Mohseni M; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, USA., Beer MA; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, USA., Foo RSY; Cardiovascular Research Institute, National University Health System, Singapore, 119074, Singapore.; Precision Medicine and Population Genomics (Germline), Genome Institute of Singapore, Singapore, Singapore., Sundar R; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore.; Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Hospital, Singapore, 119074, Singapore., Chan YH; Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore., Skanderup AJ; Precision Medicine and Population Genomics (Somatic), Genome Institute of Singapore, Singapore, 138672, Singapore., White KP; The Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, USA. kevin@tempus.com.; Tempus Labs, Chicago, USA. kevin@tempus.com., Jha S; Department of Biochemistry, National University of Singapore, Singapore, 117596, Singapore. csisjha@nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csisjha@nus.edu.sg.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. csisjha@nus.edu.sg.; Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA. csisjha@nus.edu.sg., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore. gmstanp@duke-nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. gmstanp@duke-nus.edu.sg.; Epigenetic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, 138672, Singapore. gmstanp@duke-nus.edu.sg.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore, 168752, Singapore. gmstanp@duke-nus.edu.sg.; Department of Physiology, National University of Singapore, Singapore, 117593, Singapore. gmstanp@duke-nus.edu.sg.; Singapore Gastric Cancer Consortium, Singapore, 119228, Singapore. gmstanp@duke-nus.edu.sg.

Publikováno v: Genome medicine [Genome Med] 2021 Oct 11; Vol. 13 (1), pp. 158. Date of Electronic Publication: 2021 Oct 11.

Deep whole-genome sequencing of 100 southeast Asian Malays.

Autor: Wong LP; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore., Ong RT, Poh WT, Liu X, Chen P, Li R, Lam KK, Pillai NE, Sim KS, Xu H, Sim NL, Teo SM, Foo JN, Tan LW, Lim Y, Koo SH, Gan LS, Cheng CY, Wee S, Yap EP, Ng PC, Lim WY, Soong R, Wenk MR, Aung T, Wong TY, Khor CC, Little P, Chia KS, Teo YY

Publikováno v: American journal of human genetics [Am J Hum Genet] 2013 Jan 10; Vol. 92 (1), pp. 52-66. Date of Electronic Publication: 2013 Jan 03.