Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity.

Autor: Sim MMS; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Mollica MY; Bloodworks Northwest Research Institute, WA, USA.; Division of Hematology, School of Medicine, University of Washington, WA, USA.; Department of Mechanical Engineering, University of Maryland, Baltimore County, MD, USA., Alfar HR; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Hollifield M; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., Chung DW; Bloodworks Northwest Research Institute, WA, USA.; Department of Biochemistry, University of Washington, WA, USA., Fu X; Bloodworks Northwest Research Institute, WA, USA.; Division of Hematology, School of Medicine, University of Washington, WA, USA., Gandhapudi S; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., Coenen DM; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Prakhya KS; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Mahmood DFD; Saha Cardiovascular Research Center, University of Kentucky, KY, USA., Banerjee M; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA., Peng C; Department of Pharmacology and Nutritional Sciences, University of Kentucky, KY, USA., Li X; Saha Cardiovascular Research Center, University of Kentucky, KY, USA., Thornton AC; Division of Infectious Disease, University of Kentucky, KY, USA., Porterfield JZ; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA.; Division of Infectious Disease, University of Kentucky, KY, USA., Sturgill JL; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., Sievert GA; Center for Clinical and Translational Science, University of Kentucky, KY, USA., Barton-Baxter M; Center for Clinical and Translational Science, University of Kentucky, KY, USA., Zheng Z; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.; Versiti Blood Research Institute, Milwaukee, WI, USA., Campbell KS; Center for Clinical and Translational Science, University of Kentucky, KY, USA., Woodward JG; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., López JA; Bloodworks Northwest Research Institute, WA, USA.; Division of Hematology, School of Medicine, University of Washington, WA, USA., Whiteheart SW; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA.; Saha Cardiovascular Research Center, University of Kentucky, KY, USA., Garvy BA; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, KY, USA., Wood JP; Department of Molecular and Cellular Biochemistry, University of Kentucky, KY, USA.; Saha Cardiovascular Research Center, University of Kentucky, KY, USA.; Division of Cardiovascular Medicine Gill Heart and Vascular Institute, University of Kentucky, KY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 09. Date of Electronic Publication: 2024 Feb 09.

Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.

Autor: Li X; Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, United States of America., Song X; Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, United States of America., Mahmood DFD; Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, United States of America., Sim MMS; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States of America., Bidarian SJ; Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, United States of America., Wood JP; Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, United States of America; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, United States of America; Division of Cardiovascular Medicine, Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, United States of America. Electronic address: Jeremy.Wood@uky.edu.

Publikováno v: Thrombosis research [Thromb Res] 2023 Oct; Vol. 230, pp. 84-93. Date of Electronic Publication: 2023 Aug 23.

Dysregulation of Protein S in COVID-19.

Autor: Sim MMS; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Wood JP; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA; Gill Heart and Vascular Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA; Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA. Electronic address: Jeremy.Wood@uky.edu.

Publikováno v: Best practice & research. Clinical haematology [Best Pract Res Clin Haematol] 2022 Sep; Vol. 35 (3), pp. 101376. Date of Electronic Publication: 2022 Aug 23.

Tissue factor release following traumatic brain injury drives thrombin generation.

Autor: Hubbard WB; Lexington Veterans' Affairs Healthcare System Lexington Kentucky USA.; Department of Physiology University of Kentucky Lexington Kentucky USA.; Spinal Cord and Brain Injury Research Center University of Kentucky Lexington Kentucky USA., Sim MMS; Department of Molecular and Cellular Biochemistry University of Kentucky Lexington Kentucky USA., Saatman KE; Department of Physiology University of Kentucky Lexington Kentucky USA.; Spinal Cord and Brain Injury Research Center University of Kentucky Lexington Kentucky USA., Sullivan PG; Lexington Veterans' Affairs Healthcare System Lexington Kentucky USA.; Spinal Cord and Brain Injury Research Center University of Kentucky Lexington Kentucky USA.; Department of Neuroscience University of Kentucky Lexington Kentucky USA., Wood JP; Department of Molecular and Cellular Biochemistry University of Kentucky Lexington Kentucky USA.; Division of Cardiovascular Medicine The Gill Heart and Vascular Institute University of Kentucky Lexington Kentucky USA.; Saha Cardiovascular Research Center University of Kentucky Lexington Kentucky USA.

Publikováno v: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2022 Jun 08; Vol. 6 (4), pp. e12734. Date of Electronic Publication: 2022 Jun 08 (Print Publication: 2022).

Recent Insights Into the Regulation of Coagulation and Thrombosis.

Autor: Li X; From the Saha Cardiovascular Research Center (X.L., J.P.W.), University of Kentucky, Lexington., Sim MMS; Department of Molecular and Cellular Biochemistry (M.M.S.S., J.P.W.), University of Kentucky, Lexington., Wood JP; From the Saha Cardiovascular Research Center (X.L., J.P.W.), University of Kentucky, Lexington.; Department of Molecular and Cellular Biochemistry (M.M.S.S., J.P.W.), University of Kentucky, Lexington.; Division of Cardiovascular Medicine (J.P.W.), University of Kentucky, Lexington.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 May; Vol. 40 (5), pp. e119-e125. Date of Electronic Publication: 2020 Apr 22.