Výsledky vyhledávání

Akademický článek

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment

Autor: Jacinta Jacob, Suchita Nadkarni, Alessia Volpe, Qi Peng, Sim L. Tung, Rosalind F. Hannen, Yasmin R. Mohseni, Cristiano Scotta, Federica M. Marelli-Berg, Robert I. Lechler, Lesley A. Smyth, Gilbert O. Fruhwirth, Giovanna Lombardi

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 324-336 (2021)

Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs has been shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clini

Externí odkaz: https://doaj.org/article/dcb780cc658b4eca9c8ec6f37d4a09f0

Zobrazit plný text záznamu

Akademický článek

The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology

Autor: Yasmin R. Mohseni, Sim L. Tung, Caroline Dudreuilh, Robert I. Lechler, Gilbert O. Fruhwirth, Giovanna Lombardi

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Cell therapy with polyclonal regulatory T cells (Tregs) has been translated into the clinic and is currently being tested in transplant recipients and patients suffering from autoimmune diseases. Moreover, building on animal models, it has been widel

Externí odkaz: https://doaj.org/article/442bb64f507847b0b9c582ae08138ba7

Zobrazit plný text záznamu

Akademický článek

Tissue specific deletion of inhibitor of kappa B kinase 2 with OX40-Cre reveals the unanticipated expression from the OX40 locus in skin epidermis.

Autor: Georgina H Cornish, Sim L Tung, Daniel Marshall, Steve Ley, Benedict P Seddon

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32193 (2012)

NF-κB signalling plays an essential role in T cell activation and generation of regulatory and memory populations in vivo. In the present study, we aimed to investigate the role of NF-κB signalling in post-activation T cells using tissue specific a

Externí odkaz: https://doaj.org/article/b5cc241c8ce9411cbf376a401fb683e8

Zobrazit plný text záznamu

Akademický článek

Outpatient-Based Therapy of Oral Fludarabine and Subcutaneous Alemtuzumab for Asian Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

Autor: William Y. K. Hwang, Claire Dearden, Yvonne S. M. Loh, Yeh C. Linn, Sim L. Tien, Gerrard K. H. Teoh, Gee F. How, Kee K. Heng, Yeow T. Goh, Lai H. Lee

Publikováno v: Advances in Hematology, Vol 2009 (2009)

Background. Intravenous alemtuzumab and fludarabine are effective in combination for the treatment of chronic lymphocytic leukemia (CLL), but require hospital visits for intravenous injection. We performed a pilot study to assess the safety and effic

Externí odkaz: https://doaj.org/article/bfed2f99fbb24c44993abe67a038ff45

Zobrazit plný text záznamu