Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sim K Singhrao"'
Autor:
Ingar Olsen, Sim K Singhrao
Publikováno v:
Journal of Oral Microbiology, Vol 12, Iss 1 (2020)
Defects, as determined by Genome-Wide Association Studies (GWAS), in the complement cascade of innate immunity have been suggested to play a key role in Alzheimer’s disease (AD). These defective genes encode sub-component 1s (C1s), complement recep
Externí odkaz:
https://doaj.org/article/1c890258e02c432098c6d0af490741e8
Autor:
Rebecca Williams, Ilyas M Khan, Kirsty Richardson, Larissa Nelson, Helen E McCarthy, Talal Analbelsi, Sim K Singhrao, Gary P Dowthwaite, Rhiannon E Jones, Duncan M Baird, Holly Lewis, Selwyn Roberts, Hannah M Shaw, Jayesh Dudhia, John Fairclough, Timothy Briggs, Charles W Archer
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13246 (2010)
BackgroundArticular cartilage displays a poor repair capacity. The aim of cell-based therapies for cartilage defects is to repair damaged joint surfaces with a functional replacement tissue. Currently, chondrocytes removed from a healthy region of th
Externí odkaz:
https://doaj.org/article/5d9c1dff7d2e4706b3841b4a41b1b7c7
Publikováno v:
Journal of Alzheimer's Disease Reports. 6:757-773
Background: Oral infection has been implicated in the possible etiology of Alzheimer’s disease. Objective: To detect amyloid-β (Aβ) within microbial biofilms. Methods: Freshly extracted teeth (N = 87) with periodontal disease were separated into
Publikováno v:
Journal of Oral Microbiology, Vol 8, Iss 0, Pp 1-13 (2016)
Porphyromonas gingivalis, a keystone pathogen in chronic periodontitis, has been found to associate with remote body organ inflammatory pathologies, including atherosclerosis and Alzheimer’s disease (AD). Although P. gingivalis has a plethora of vi
Externí odkaz:
https://doaj.org/article/267f72301d6f4915aa048f12dc837406
Autor:
Ingar Olsen, Sim K. Singhrao
Publikováno v:
Journal of Oral Microbiology, Vol 7, Iss 0, Pp 1-16 (2015)
Alzheimer's disease (AD) is a scourge of longevity that will drain enormous resources from public health budgets in the future. Currently, there is no diagnostic biomarker and/or treatment for this most common form of dementia in humans. AD can be of
Externí odkaz:
https://doaj.org/article/57e77b9c68ea48f1a0fd05fb0a9cedc2
Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer’s Disease
Autor:
Sim K. Singhrao, Alice Harding, Tal Simmons, Sarita Robinson, Lakshmyya Kesavalu, StJohn Crean
Periodontitis is a polymicrobial chronic inflammatory disease of tooth-supporting tissues with bacterial etiology affecting all age groups, becoming chronic in a subgroup of older individuals. Periodontal pathogens Porphyromonas gingivalis, Tannerell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb30636b065e2140fbea6258888db9c
https://doi.org/10.3233/aiad220038
https://doi.org/10.3233/aiad220038
Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer’s Disease?
A risk factor relationship exists between periodontal disease and Alzheimer’s disease (AD) via tooth loss, and improved memory following dental intervention. This links the microbial contribution from indigenous oral periodontal pathogens to the ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6997151ea29e528e7c53f0811e2688b5
https://doi.org/10.3233/aiad220040
https://doi.org/10.3233/aiad220040
Publikováno v:
Advances in experimental medicine and biology. 1373
Periodontitis and Alzheimer's disease (AD) exist globally within the adult population. Given that the risk of AD incidence doubles within 10 years from the time of periodontal disease diagnosis, there is a window of opportunity for slowing down or pr
Publikováno v:
Periodontitis ISBN: 9783030968809
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc33b8ce91a97f15ce79b0d0cc9295b
https://doi.org/10.1007/978-3-030-96881-6_13
https://doi.org/10.1007/978-3-030-96881-6_13
Publikováno v:
International Journal of Environmental Research and Public Health. 20:1007
Alzheimer’s disease (AD) is a leading neurodegenerative disease with deteriorating cognition as its main clinical sign. In addition to the clinical history, it is characterized by the presence of two neuropathological hallmark lesions; amyloid-beta