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pro vyhledávání: '"Sim, Lesley"'
Growing evidence indicates that small extracellular vesicles, called exosomes, are prominent mediators of neurodegenerative diseases such as prion, Alzheimer’s and Parkinson’s disease. Exosomes contain neurodegenerative disease associated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585c9ec212feb7a5237a2ec68d795b31
Autor:
Huang, Y, Driedonks, TAP, Sim, Lesley, Rajapaksha, Kolin, Turchinovich, A, Routenberg, DA, Nagaraj, R, Redding-Ochoa, J, Arab, T, Powell, BH, Pletnikova, O, Troncoso, JC, Zheng, L, Hill, Andrew, Mahairaki, V, Witwer, KW
Background and Objectives: Variants of the apolipoprotein E (APOE) gene are the greatest known risk factors for sporadic Alzheimer disease (AD). Three major APOE isoform alleles, ϵ2, ϵ3, and ϵ4, encode and produce proteins that differ by only 1-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e3c599e40cd4aa6f1fb2b796f00131
The administration of MPTP selectively targets the dopaminergic system resulting in Parkinsonism-like symptoms and is commonly used as a mice model of Parkinson's disease. We previously demonstrated that the neuroprotective compound CuII (atsm) rescu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d53c243d264013fd53493c8698949a4
Prion diseases (PrD) or transmissible spongiform encephalopathies (TSE) are invariably fatal and pathogenic neurodegenerative disorders caused by the self-propagated misfolding of cellular prion protein (PrPC) to the neurotoxic pathogenic form (PrPTS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ae426b5ba7c0f9a46a9ac184e0db87
Akademický článek
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© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles. Alzheimer’s disease is a progressive neurodegenerative disorder, with the stronges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90555684245f881f1a393d034ddb5efa
Autor:
Amirmohammad Nasiri Kenari, Kastaniegaard, Kenneth, Greening, David, Shambrook, Mitch, Stensballe, Allan, Sim, Lesley, Hill, Andrew
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Issues associated with upscaling exosome production for therapeutic use may be overcome through utilizing artificial exosomes. Cell-derived mimetic nanovesicles (M-NVs) are a potentially promising al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28896ee02a81f801253bade76e8c760a
Autor:
Sim, Lesley, C Quek, Li, Xia, SA Bellingham, LJ Ellett, Shambrook, Mitch, S Zafar, I Zerr, VA Lawson, Hill, Andrew
Prion diseases are distinguished by long pre-clinical incubation periods during which prions actively propagate in the brain and cause neurodegeneration. In the pre-clinical stage, we hypothesize that upon prion infection, transcriptional changes occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0773a2ea7e8557c537fd66943ded12c6
Autor:
Vassileff, Natasha, LJ Vella, Kolin Rajapaksha, Shambrook, Mitch, Amirmohammad Nasiri Kenari, C McLean, Hill, Andrew, Sim, Lesley
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the deposition of misfolded proteins in the motor cortex and motor neurons. Although a multitude of ALS-associated mutated proteins have been identified, several have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4387f4f3d4d966c66080665116f5250e
Autor:
D Kim, J Lee, S Kim, D Choi, Y Yoon, J Kim, G Go, D Nhung, K Hong, S Jang, K Park, O Kim, H Park, J Seo, E Aikawa, M Baj-Krzyworzeka, B Van, M Belting, L Blanc, V Bond, A Bongiovanni, F Borras, L Buee, E Buzas, Sim, Lesley, A Clayton, E Cocucci, C Dela, D Desiderio, V Di, K Ekstrom, J Falcon-Perez, C Gardiner, B Giebel, Greening, David, J Gross, D Gupta, A Hendrix, Hill, Andrew, M Hill, E Hoen, D Hwang, J Inal, M Jagannadham, M Jayachandran, Y Jee, M Jorgensen, K Kim, Y Kim, T Kislinger, C Lasser, D Lee, H Lee, L Van, T Lener, M Liu, J Lotvall, A Marcilla, Mathivanan, Suresh, A Moeller, J Morhayim, F Mullier, I Nazarenko, R Nieuwland, D Nunes, K Pang, J Park, T Patel, G Pocsfalvi, P Del, U Putz, M Ramirez, M Rodrigues, T Roh, F Royo, S Sahoo, R Schiffelers, S Sharma, P Siljander, Simpson, Richard, C Soekmadji, P Stahl, A Stensballe, E Stepien, H Tahara, A Trummer, H Valadi, L Vella, S Wai, K Witwer, M Yanez-Mo, H Youn, R Zeidler, Y Gho
© The Author 2014. Published by Oxford University Press. All rights reserved. Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281a28d308442bd321b09712beab5fc0