Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Silviya D Furdas"'
Autor:
Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Eduardo José Lopes Torres, Stephany Caby, Julien Lancelot, Mathieu Vanderstraete, Silviya D Furdas, Manfred Jung, Raymond J Pierce, Marcelo Rosado Fantappié
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004116 (2014)
Treatment and control of schistosomiasis relies on the only available drug, praziquantel, and the search for alternative chemotherapeutic agents is therefore urgent. Egg production is required for the transmission and immunopathology of schistosomias
Externí odkaz:
https://doaj.org/article/510576f87bbf475a8b1ca3e4cd56c6a8
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45594 (2012)
Two major plasma proteins in humans are primarily responsible for drug binding, the α(1)-acid-glycoprotein (AGP) and human serum albumin (HSA). The availability of at least a semiquantitative high-throughput assay for assessment of protein binding i
Externí odkaz:
https://doaj.org/article/aebe8a79cdd042f2bda090251433507d
Autor:
Gerald M. Cohen, Martin J.S. Dyer, Tomomi Kuwana, Manfred Jung, Silviya D. Furdas, Meike Vogler
Purpose: Inhibition of the antiapoptotic BCL2 family is one of the most promising areas of anticancer drug development. However, ABT-737, a specific BCL2 inhibitor, is neither orally bioavailable nor metabolically stable. To overcome these problems,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21372bce90f65aab247537aec092e041
https://doi.org/10.1158/1078-0432.c.6518951
https://doi.org/10.1158/1078-0432.c.6518951
Autor:
Gerald M. Cohen, Martin J.S. Dyer, Tomomi Kuwana, Manfred Jung, Silviya D. Furdas, Meike Vogler
Supplementary Figure S1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c12525ae51321017aabe00cb506db9
https://doi.org/10.1158/1078-0432.22442144.v1
https://doi.org/10.1158/1078-0432.22442144.v1
Publikováno v:
MedChemComm. 3:123-134
A multitude of epigenetic regulatory mechanisms is reflected in the dynamic nature of chromatin during different development stages as well as pathological states of human organisms. Apart from enzymatic processes, the recognition of histone modifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::982c3e046f40315769d923da1e9233d9
https://doi.org/10.1039/c1md00201e
https://doi.org/10.1039/c1md00201e
Publikováno v:
MedChemComm. 3:305-311
Histone acetyltransferases (HATs) are promising epigenetic drug targets and are involved in the pathogenesis of a wide range of diseases. We carried out a virtual screening based on inhibitors of serotonin N-acetyltransferase and identified novel inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7081127004fb82b9e80d3313f85fb01b
https://doi.org/10.1039/c2md00211f
https://doi.org/10.1039/c2md00211f
Publikováno v:
Archiv der Pharmazie. 345:7-21
Alteration of the acetylation state of histone proteins contributes to transcriptional regulation and epigenetic inheritance. Dysregulation of these processes may lead to human diseases, especially cancer. One of the major chromatin modifications is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2115790d0ecaf91e5d766cdcc7f1d0d6
https://doi.org/10.1002/ardp.201100209
https://doi.org/10.1002/ardp.201100209
Autor:
Tomomi Kuwana, Martin J. S. Dyer, Silviya D. Furdas, Meike Vogler, Gerald M. Cohen, Manfred Jung
Publikováno v:
Clinical Cancer Research. 16:4217-4225
Purpose: Inhibition of the antiapoptotic BCL2 family is one of the most promising areas of anticancer drug development. However, ABT-737, a specific BCL2 inhibitor, is neither orally bioavailable nor metabolically stable. To overcome these problems,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7095d6122a6c8a1dfe4db43a2fb56c59
https://doi.org/10.1158/1078-0432.ccr-10-0777
https://doi.org/10.1158/1078-0432.ccr-10-0777
Autor:
Silviya D. Furdas, Asifa Akhtar, Inga Hoffmann, Piotr Świątek, B. Herquel, Manfred Jung, Wiesław Malinka, Wolfgang Sippl, Dina Robaa
Publikováno v:
Medicinal Chemistry Communications
Histone acetyltransferases (HATs) are interesting targets for the treatment of cancer and HIV infections but reports on selective inhibitors are very limited. Here we report structure–activity studies of pyrido- and benzisothiazolones in the in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bfa73c05dac19a822120620bf8e31b
https://hdl.handle.net/21.11116/0000-000A-1C3B-621.11116/0000-000A-1C3D-4
https://hdl.handle.net/21.11116/0000-000A-1C3B-621.11116/0000-000A-1C3D-4
Autor:
Mathieu Vanderstraete, Stephany Caby, Julien Lancelot, Isabel Caetano de Abreu da Silva, Vitor Coutinho Carneiro, Eduardo José Lopes Torres, Manfred Jung, Raymond J. Pierce, Marcelo Rosado Fantappié, Silviya D. Furdas
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004116 (2014)
PLoS Pathogens
PLoS Pathogens
Treatment and control of schistosomiasis relies on the only available drug, praziquantel, and the search for alternative chemotherapeutic agents is therefore urgent. Egg production is required for the transmission and immunopathology of schistosomias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871ee8e5f1a2edcd63403e7b923d7d96
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24809504/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24809504/pdf/?tool=EBI