Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Silvio Weber"'
Autor:
Natalie Francis, Marion Braun, Sarah Neagle, Sabine Peiffer, Alexander Bohn, Alexander Rosenthal, Tanita Olbrich, Sophia Lollies, Keijo Ilsmann, Carola Hauck, Bernhard Gerstmayer, Silvio Weber, Aileen Kirkpatrick
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101114- (2023)
Engineered T cell therapies have shown significant clinical success. However, current manufacturing capabilities present a challenge in bringing these therapies to patients. Furthermore, the cost of development and manufacturing is still extremely hi
Externí odkaz:
https://doaj.org/article/d2aaee572b3f4226aa3ac1e259fe612a
Autor:
Erik Klapproth, Anke Witt, Pauline Klose, Johanna Wiedemann, Nikitha Vavilthota, Stephan R. Künzel, Susanne Kämmerer, Mario Günscht, David Sprott, Mathias Lesche, Fabian Rost, Andreas Dahl, Erik Rauch, Lars Kattner, Silvio Weber, Peter Mirtschink, Irakli Kopaliani, Kaomei Guan, Kristina Lorenz, Paul Saftig, Michael Wagner, Ali El-Armouche
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Therapeutic interference with the immune response after myocardial infarction holds the potential to close a clinically relevant gap. Here, the authors show that inhibition of a cardiomyocyte-specific ADAM10 / CX3CL1 axis improves post infarction sur
Externí odkaz:
https://doaj.org/article/8d786fd470964db7bb4c1cae17ec3150
Autor:
Thimios A. Mitsiadis, Lucia Jimenez-Rojo, Anamaria Balic, Silvio Weber, Paul Saftig, Pierfrancesco Pagella
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105154- (2022)
Summary: The disintegrin and metalloproteinase Adam10 is a membrane-bound sheddase that regulates Notch signaling and ensures epidermal integrity. To address the function of Adam10 in the continuously growing incisors, we used Keratin14Cre/+;Adam10fl
Externí odkaz:
https://doaj.org/article/2bef9521aac44f0389397a98e8516878
Autor:
Felix W. Friedrich, Hannieh Sotoud, Birgit Geertz, Silvio Weber, Frederik Flenner, Silke Reischmann, Thomas Eschenhagen, Lucie Carrier, Ali El-Armouche
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 8, Iss C, Pp 87-94 (2015)
Aims: Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis. Current treatment is based on beta-adrenoceptor (AR) and calcium channel blockers. Since mice deficie
Externí odkaz:
https://doaj.org/article/e8c2dbbdb4be462c88dcc33c4e71d251
Autor:
Silvio Weber, Maximilian Hoffmann, Susanne Kämmerer, Molly O’Reilly, Ali El-Armouche, Mirna S. Sadek, Sems Malte Tugtekin, Ben Wielockx, Pauline Wimberger, Mario Günscht, L C Sommerfeld, Natalie Herzog, Ursula Ravens, Larissa Fabritz, Stefan Rose-John, Jan-Heiner Küpper, Kaomei Guan, Erik Klapproth, S. Nashitha Kabir, Tomasz Kolanowski, Jan Dominik Kuhlmann, Michael Wagner, Manuel Mayr, Stefanie Meyer-Roxlau, Stephan R Künzel, Konrad Grützmann, Stanley Nattel, Karolina Künzel, Xiaoke Yin, C. Piorkowski, Johanna S E Rausch, Dobromir Dobrev
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will o
Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e048dfbc460665ba37f1c2b2bbe8d1
https://www.ncbi.nlm.nih.gov/pubmed/34433292
https://www.ncbi.nlm.nih.gov/pubmed/34433292
Autor:
Silvio Weber, Manuel Mayr, Erik Klapproth, Ali El-Armouche, Johanna S E Rausch, Michael Wagner, Christopher Piorkowski, Ursula Ravens, Stephan R. Kuenzel, K Kuenzel, Dobromir Dobrev
Publikováno v:
European Heart Journal. 41
Background and aim Atrial fibrillation (AF) is frequently accompanied by cardiac fibrosis and diastolic heart failure. Due to the heterogeneous nature and complexity of fibrosis, the knowledge of the underlying pathomechanisms is limited. Thus, effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f434495667841fcbc94811c95dbcde46
https://doi.org/10.1093/ehjci/ehaa946.3671
https://doi.org/10.1093/ehjci/ehaa946.3671
Autor:
Ali El-Armouche, M Guenscht, Stephan R. Kuenzel, Kristina Lorenz, Silvio Weber, Erik Klapproth, Kaomei Guan
Publikováno v:
European Heart Journal. 41
Background and purpose Following myocardial infarction (MI), adverse fibrotic remodeling with extensive deposition of extracellular matrix (ECM) components has substantial consequences for the contractility of the ventricle finally leading to termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff257137788ae3bb7f6226448ac6f75c
https://doi.org/10.1093/ehjci/ehaa946.3640
https://doi.org/10.1093/ehjci/ehaa946.3640
Autor:
Senka Ljubojevic, Steffen Pabel, Gerd Hasenfuß, Theodor Tirilomis, Yansong Wang, André Renner, Ali El-Armouche, Thomas H. Fischer, Silvio Weber, Jan Gummert, Alireza Saadatmand, Jörg Eiringhaus, Samuel Sossalla, Maja Köhn, Nataliya Dybkova, Lars S. Maier
Publikováno v:
European Journal of Heart Failure. 20:1673-1685
Background Disruption of Ca2+ homeostasis is a key pathomechanism in heart failure. CaMKII-dependent hyperphosphorylation of ryanodine receptors in the sarcoplasmic reticulum (SR) increases the arrhythmogenic SR Ca2+ leak and depletes SR Ca2+ stores.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6110844862e05ad9eb73de77c12fc903
https://doi.org/10.1002/ejhf.1297
https://doi.org/10.1002/ejhf.1297
Publikováno v:
Cellular Signalling. 38:76-84
The cyclic nucleotides cAMP and cGMP are central second messengers in cardiac cells and critical regulators of cardiac physiology as well as pathophysiology. Consequently, subcellular compartmentalization allows for spatiotemporal control of cAMP/cGM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab94e22a6a6605b3f11c3cff583cee8f
https://doi.org/10.1016/j.cellsig.2017.06.020
https://doi.org/10.1016/j.cellsig.2017.06.020
Publikováno v:
Journal of Molecular and Cellular Cardiology. 101:116-126
Phosphoproteomic studies have shown that about one third of all cardiac proteins are reversibly phosphorylated, affecting virtually every cellular signaling pathway. The reversibility of this process is orchestrated by the opposing enzymatic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f5d0cb0a73f46e9a3d445178d161e7
https://doi.org/10.1016/j.yjmcc.2016.09.007
https://doi.org/10.1016/j.yjmcc.2016.09.007