Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Silvio R. Meier"'
Autor:
María Pagnon de la Vega, Stina Syvänen, Vilmantas Giedraitis, Monique Hooley, Evangelos Konstantinidis, Silvio R. Meier, Johanna Rokka, Jonas Eriksson, Ximena Aguilar, Tara L. Spires-Jones, Lars Lannfelt, Lars N. G. Nilsson, Anna Erlandsson, Greta Hultqvist, Martin Ingelsson, Dag Sehlin
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer’s disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation properties of Aβ. We recentl
Externí odkaz:
https://doaj.org/article/e1e6c9096c0f4e3e9f714a2564198215
Autor:
Fadi Rofo, Silvio R. Meier, Nicole G. Metzendorf, Jamie I. Morrison, Alex Petrovic, Stina Syvänen, Dag Sehlin, Greta Hultqvist
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 19(5)
Amyloid-β (Aβ) oligomers and protofibrils are suggested to be the most neurotoxic Aβ species in Alzheimer’s disease (AD). Hence, antibodies with strong and selective binding to these soluble Aβ aggregates are of therapeutic potential. We have r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a391a2486147bf031ef5b497248e463f
https://pubmed.ncbi.nlm.nih.gov/35939261
https://pubmed.ncbi.nlm.nih.gov/35939261
Autor:
Stina Syvänen, Silvio R. Meier, Sahar Roshanbin, Mengfei Xiong, Rebecca Faresjö, Tobias Gustavsson, Gillian Bonvicini, Eva Schlein, Ximena Aguilar, Ulrika Julku, Jonas Eriksson, Dag Sehlin
Positron emission tomography (PET), a medical imaging technique allowing for studies of the living human brain, has gained an important role in clinical trials of novel drugs against Alzheimer’s disease (AD). For example, PET data contributed to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc643bb4a01e26758bf8e39ac35425e
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483631
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483631
Purpose: Antibody-based constructs, engineered to enter the brain using transferrin receptor (TfR) mediated transcytosis, have been successfully used as PET radioligands for imaging of amyloid-beta (Aβ) in preclinical studies. However, these radioli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39e7869ebe32c94b9b58997bb3d8771
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-437973
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-437973
Publikováno v:
Molecular Imaging and Biology
Purpose The triggering receptor expressed on myeloid cells 2 (TREM2) is expressed by brain microglia. Microglial activation, as observed in Alzheimer’s disease (AD) as well as in transgenic mice expressing human amyloid-beta, appears to increase so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e6a410417c80bc8a525461e8c5e6f0
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-437686
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-437686
Autor:
Wojciech Michno, Silvio R. Meier, Kaj Blennow, Stina Syvänen, Dag Sehlin, Jörg Hanrieder, Henrik Zetterberg, Patrick M. Wehrli
Publikováno v:
Journal of neurochemistryReferences. 152(5)
One of the major hallmarks of Alzheimer's disease (AD) pathology is the formation of extracellular amyloid β (Aβ) plaques. While Aβ has been suggested to be critical in inducing and, potentially, driving the disease, the molecular basis of AD path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa0e4ce8b8b3048aa3899e0ff94b04c
https://pubmed.ncbi.nlm.nih.gov/31605538
https://pubmed.ncbi.nlm.nih.gov/31605538
Autor:
Xiaotian T, Fang, Greta, Hultqvist, Silvio R, Meier, Gunnar, Antoni, Dag, Sehlin, Stina, Syvänen
Publikováno v:
NeuroImage. 184
PET imaging of amyloid-beta (Aβ) deposits in brain has become an important aid in Alzheimer's disease diagnosis, and an inclusion criterion for patient enrolment into clinical trials of new anti-Aβ treatments. Available PET radioligands visualizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39caaff29d9b89b0646942895fbdfa91
https://pubmed.ncbi.nlm.nih.gov/30300753
https://pubmed.ncbi.nlm.nih.gov/30300753
Autor:
Silvio R, Meier, Stina, Syvänen, Greta, Hultqvist, Xiaotian T, Fang, Sahar, Roshanbin, Lars, Lannfelt, Ulf, Neumann, Dag, Sehlin
Publikováno v:
Journal of Nuclear Medicine
Visualization of amyloid-β (Aβ) pathology with PET has become an important tool for making a specific clinical diagnosis of Alzheimer disease (AD). However, the available amyloid PET radioligands, such as 11C-Pittsburgh compound B, reflect levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a62216c73b12f8908615f741eaae735d
https://pubmed.ncbi.nlm.nih.gov/29853653
https://pubmed.ncbi.nlm.nih.gov/29853653
Autor:
Stina, Syvänen, Xiaotian T, Fang, Greta, Hultqvist, Silvio R, Meier, Lars, Lannfelt, Dag, Sehlin
Publikováno v:
NeuroImage. 148
Antibodies are highly specific for their target molecules, but their poor brain penetrance has restricted their use as PET ligands for imaging of targets within the CNS. The aim of this study was to develop an antibody-based radioligand, using the Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6343f250fb6a5e2cef1d702a88f74faf
https://pubmed.ncbi.nlm.nih.gov/28069541
https://pubmed.ncbi.nlm.nih.gov/28069541