Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Silvio H. Litovsky"'
Autor:
Arun Jyothidasan, Sini Sunny, Asokan Devarajan, Aniqa Sayed, John Kofi Afortude, Brian Dalley, Vivek Nanda, Steven Pogwizd, Silvio H. Litovsky, Joel D. Trinity, Matthew Might, Namakkal S. Rajasekaran
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103263- (2024)
The endoplasmic reticulum (ER) regulates protein folding and maintains proteostasis in cells. We observed that the ER transcriptome is impaired during chronic reductive stress (RS) in cardiomyocytes. Here, we hypothesized that a prolonged moderate tr
Externí odkaz:
https://doaj.org/article/89d8b21237c04432b90821ae7822b5b0
Autor:
Mariame S. Kane, Gloria A. Benavides, Edie Osuma, Michelle S. Johnson, Helen E. Collins, Yecheng He, David Westbrook, Silvio H. Litovsky, Kasturi Mitra, John C. Chatham, Victor Darley-Usmar, Martin E. Young, Jianhua Zhang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Mitochondria morphology and function, and their quality control by mitophagy, are essential for heart function. We investigated whether these are influenced by time of the day (TOD), sex, and fed or fasting status, using transmission electro
Externí odkaz:
https://doaj.org/article/404d2c5db08241938901383fabf3f138
Autor:
Timothy G. Norwood, Carrie A. Lenneman, MD, Brian C. Westbrook, Silvio H. Litovsky, MD, Svetlana B. McKee, RN, BSN, Robert M. Conry, MD
Publikováno v:
JACC: Case Reports, Vol 2, Iss 2, Pp 203-209 (2020)
Ipilimumab and nivolumab for melanoma induced smoldering myocarditis remitting with steroids. Rechallenge with nivolumab produced steroid-refractory myocarditis confirmed by electron microscopy. Tacrolimus and mycophenolate transiently reduced inflam
Externí odkaz:
https://doaj.org/article/5defb6f3435e4bbeb14a04c093d865bb
Autor:
Timothy G. Norwood, Brian C. Westbrook, Douglas B. Johnson, Silvio H. Litovsky, Nina L. Terry, Svetlana B. McKee, Alan S. Gertler, Javid J. Moslehi, Robert M. Conry
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-6 (2017)
Abstract Background Severe myocarditis associated with electrical conduction abnormalities and occasionally heart failure has been well documented following treatment with immune checkpoint blockade with an estimated incidence of less than 1%. Howeve
Externí odkaz:
https://doaj.org/article/954f4ac729624cc49ee9c4c13eb10484
Autor:
Gobinath Shanmugam, Anil Kumar Challa, Silvio H. Litovsky, Asokan Devarajan, Ding Wang, Dean P. Jones, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran
Publikováno v:
Redox Biology, Vol 27, Iss , Pp - (2019)
Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/Nrf2) is an inducible transcription factor that is essential for maintenance of redox signaling in response to stress. This suggests that if Nrf2 expression response could be enhanced for a defined
Externí odkaz:
https://doaj.org/article/d793471ae9e74e498465e7ebe4d51c7a
Autor:
Gobinath Shanmugam, Anil K. Challa, Asokan Devarajan, Baskaran Athmanathan, Silvio H. Litovsky, Prasanna Krishnamurthy, Christopher J. Davidson, Namakkal Soorappan Rajasekaran
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Although exercise derived activation of Nrf2 signaling augments myocardial antioxidant signaling, the molecular mechanisms underlying the benefits of moderate exercise training (MET) in the heart remain elusive. Here we hypothesized that exercise tra
Externí odkaz:
https://doaj.org/article/b7425631e0854972ae1c0e78b74a584d
Autor:
Jeremy B. Foote, Silvio H. Litovsky, Hidetaka Hara, Luz A. Padilla, Carlisle O’Meara, Jack H. Crawford, Robert J. Dabal, Robert A Sorabella, Takayuki Yamamoto, Gregory P. Walcott, Leslie A. Rhodes, Abhijit Jagdale, David Ayares, David C. Cleveland, Waldemar F. Carlo, Hayato Iwase, David C. Mauchley, Mohamed H Bikhet, Joey Timpa, David K. C. Cooper
Publikováno v:
The Annals of Thoracic Surgery. 114:536-544
Background Mortality for infants on the heart transplant wait list remains unacceptably high, and available mechanical circulatory support is suboptimal. Our goal is to demonstrate the feasibility of utilizing genetically engineered pig (GEP) heart a
Autor:
Hongshan Liu, Xueshen Li, Abdul Latif Bamba, Xiaoyu Song, Brigitta C. Brott, Silvio H. Litovsky, Yu Gan
Publikováno v:
Journal of Biomedical Optics. 28
Autor:
Karen L. Kelly, Peter T. Lin, Cristina Basso, Melanie Bois, L. Maximilian Buja, Stephen D. Cohle, Giulia d'Amati, Emily Duncanson, John T. Fallon, Dennis Firchau, Gregory Fishbein, Carla Giordano, Charles Leduc, Silvio H. Litovsky, Shannon Mackey-Bojack, Joseph J. Maleszewski, Katarzyna Michaud, Robert F. Padera, Stavroula A. Papadodima, Sarah Parsons, Stanley J. Radio, Stefania Rizzo, Susan J. Roe, Maria Romero, Mary N. Sheppard, James R. Stone, Carmela D. Tan, Gaetano Thiene, Allard C. van der Wal, John P. Veinot
Publikováno v:
Cardiovascular pathology, vol. 63, pp. 107497
Sudden cardiac death is, by definition, an unexpected, untimely death caused by a cardiac condition in a person with known or unknown heart disease. This major international public health problem accounts for approximately 15-20% of all deaths. Typic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce49132102e3db6f60875cd7030e792
https://serval.unil.ch/resource/serval:BIB_139426CA3984.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_139426CA3984.P001/REF.pdf
Autor:
Jiajie Yan, Steven M. Pogwizd, Greg Walcott, Jian Huang, Cheryl R. Killingsworth, Yujie Zhu, Xun Ai, Silvio H. Litovsky
Publikováno v:
J Mol Cell Cardiol
Background Both gap junctional remodeling and interstitial fibrosis have been linked to impaired electrical conduction velocity (CV) and fatal ventricular arrhythmias in nonischemic heart failure (HF). However, the arrhythmogenic role of the ventricu