Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Silvio Campagna"'
Autor:
Yongbo Hu, James Cutter, Naoki Asai, Taichi Abe, Hyeong-Wook Choi, Teiji Takigawa, Taiju Nakamura, Thomas Noland, Masanori Mizuno, Atsushi Endo, Marc Pesant, Michael D. Lewis, Takao Omae, Bryan M. Lewis, Kazuhiro Yoshizawa, Francis G. Fang, Tomohiro Watanabe, Shawn McKenna, William J. Christ, Naoki Ozeki, Brian Austad, Gordon D. Wilkie, Hirofumi Kuroda, Trevor Lee Calkins, Manabu Kubota, Akio Kayano, Yumi Asai, John D. Orr, Matthew J. Schnaderbeck, Farid Benayoud, Yuki Komatsu, Robert Costanzo, Silvio Campagna, Taeko Suzuki, Charles E. Chase, Yuichi Kimoto
Publikováno v:
Synlett. 24:327-332
Multikilogram manufacturing process of the Halaven® C14–C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.
Autor:
Mathew Yates, Pat N. Confalone, Robert E. Waltermire, Silvio Campagna, Scott A. Savage, Robert Wethman, David J. Meloni, Nicholas A. Magnus
Publikováno v:
Organic Process Research & Development. 14:159-167
The d-leucine amino acid residue necessary for the synthesis of BMS-561392, 1, was employed as a chiral directing group for a diastereoselective enolate amination to establish the quaternary chiral center. Enhanced diastereomeric ratios were observed
Autor:
Robert E. Waltermire, Silvio Campagna, Joan Dalla Riva Toma, Shailendra Bordawekar, Scott A. Savage
Publikováno v:
Organic Process Research & Development. 13:510-518
An efficient, expedient synthesis of BMS-561392, 1, which enabled rapid delivery of drug substance for clinical development is described. The key features of the synthesis include an efficient synthesis of a phenolic α,α-disubstituted amino ester v
Publikováno v:
ChemInform. 31
Autor:
Guoyou Xu, Pat N. Confalone, Silvio Campagna, Zhe Wang, Michael E. Pierce, Kaihong Yang, Joseph M. Fortunak
Publikováno v:
ChemInform. 31
Autor:
Silvio Campagna, Zhe Wang, Joseph M. Fortunak, Pat N. Confalone, Michael E. Pierce, Guoyou Xu
Publikováno v:
ChemInform. 31
A practical approach for the conversion of aldehydes to vinyl dichlorides has been developed. These are three-step, one-pot reactions involving the formation of trichlorocarbinol by treatment of aldehydes with trichloroacetic acid and sodium trichlor
Autor:
Pat N. Confalone, Joseph M. Fortunak, Silvio Campagna, Zhe Wang, Michael E. Pierce, Guoyou Xu
Publikováno v:
Tetrahedron Letters. 41:4007-4009
A practical approach for the conversion of aldehydes to vinyl dichlorides has been developed. These are three-step, one-pot reactions involving the formation of trichlorocarbinol by treatment of aldehydes with trichloroacetic acid and sodium trichlor
Autor:
Junke Liu, Francis G. Fang, Silvio Campagna, Edward M. Suh, Veronique Marceau, Ye Yao, James J. Kowalczyk, Shawn Schiller, Hongsheng Cheng, Galina Kuznetsov, Karen TenDyke, Bruce A. Littlefield, Hu Yang, Murray J. Towle, Christina J. Shaffer, Mark Spyvee, Joanne Marsh, Boris M. Seletsky
Publikováno v:
Molecular cancer therapeutics. 8(10)
E7974 is a synthetic analogue of the marine sponge natural product hemiasterlin. Here, we show that E7974, such as parental hemiasterlin, acts via a tubulin-based antimitotic mechanism. E7974 inhibits polymerization of purified tubulin in vitro with
Publikováno v:
The Journal of Organic Chemistry. 64:6918-6920
Autor:
Michael E. Pierce, Joseph M. Fortunak, Zhe Wang, Guoyou Xu, Pat N. Confalone, Kaihong Yang, Silvio Campagna
Publikováno v:
The Journal of organic chemistry. 65(6)