Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Silvio C. E. Tosatto"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4710 (2023)
The Prolyl Hydroxylases (PHDs) are an enzymatic family that regulates cell oxygen-sensing. PHDs hydroxylate hypoxia-inducible transcription factors α (HIFs-α) driving their proteasomal degradation. Hypoxia inhibits PHDs activity, inducing HIFs-α s
Externí odkaz:
https://doaj.org/article/3119ce4c4510431cabae67bfc4cb0a23
Publikováno v:
Open Biology, Vol 10, Iss 7 (2020)
The von Hippel–Lindau protein (pVHL) is a tumour suppressor mainly known for its role as master regulator of hypoxia-inducible factor (HIF) activity. Functional inactivation of pVHL is causative of the von Hippel–Lindau disease, an inherited pred
Externí odkaz:
https://doaj.org/article/f3b0449ecae34863a12c64a1929c0cfb
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The emergence of genes implicated across multiple comorbid neurologic disorders allows to identify shared underlying molecular pathways. Recently, investigation of patients with diverse neurologic disorders found TANC1 and TANC2 as possible
Externí odkaz:
https://doaj.org/article/9f4c79e77cbb4bdda097db6a4d6e5c4b
Autor:
Norman E. Davey, M. Madan Babu, Martin Blackledge, Alan Bridge, Salvador Capella-Gutierrez, Zsuzsanna Dosztanyi, Rachel Drysdale, Richard J. Edwards, Arne Elofsson, Isabella C. Felli, Toby J. Gibson, Aleksandras Gutmanas, John M. Hancock, Jen Harrow, Desmond Higgins, Cy M. Jeffries, Philippe Le Mercier, Balint Mészáros, Marco Necci, Cedric Notredame, Sandra Orchard, Christos A. Ouzounis, Rita Pancsa, Elena Papaleo, Roberta Pierattelli, Damiano Piovesan, Vasilis J. Promponas, Patrick Ruch, Gabriella Rustici, Pedro Romero, Sirarat Sarntivijai, Gary Saunders, Benjamin Schuler, Malvika Sharan, Denis C. Shields, Joel L. Sussman, Jonathan A. Tedds, Peter Tompa, Michael Turewicz, Jiri Vondrasek, Wim F. Vranken, Bonnie Ann Wallace, Kanin Wichapong, Silvio C. E. Tosatto
Publikováno v:
F1000Research, Vol 8 (2019)
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP res
Externí odkaz:
https://doaj.org/article/394ab68cdf814790908372f98b29dde4
Autor:
Valentin Iglesias, Lisanna Paladin, Teresa Juan-Blanco, Irantzu Pallarès, Patrick Aloy, Silvio C. E. Tosatto, Salvador Ventura
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Prion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the regulation of processes such as t
Externí odkaz:
https://doaj.org/article/0b252a4eb5814790b15de127005c4d2b
Autor:
Alexander Miguel Monzon, Marco Necci, Federica Quaglia, Ian Walsh, Giuseppe Zanotti, Damiano Piovesan, Silvio C. E. Tosatto
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4496 (2020)
Intrinsically disordered protein regions are commonly defined from missing electron density in X-ray structures. Experimental evidence for long disorder regions (LDRs) of at least 30 residues was so far limited to manually curated proteins. Here, we
Externí odkaz:
https://doaj.org/article/e1acc286f2a44e91b0b34aad82e9a160
Autor:
Gabriella Margherita Mazzotta, Massimo Bellanda, Giovanni Minervini, Milena Damulewicz, Paola Cusumano, Simona Aufiero, Monica Stefani, Barbara Zambelli, Stefano Mammi, Rodolfo Costa, Silvio C. E. Tosatto
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Light is the main environmental stimulus that synchronizes the endogenous timekeeping systems in most terrestrial organisms. Drosophila cryptochrome (dCRY) is a light-responsive flavoprotein that detects changes in light intensity and wavelength arou
Externí odkaz:
https://doaj.org/article/4e87d43da25e4c8fa20f3a47d358d59d
Autor:
Damiano Piovesan, Alessio Del Conte, Damiano Clementel, Alexander Miguel Monzon, Martina Bevilacqua, Maria Cristina Aspromonte, Javier A Iserte, Fernando E Orti, Cristina Marino-Buslje, Silvio C E Tosatto
Publikováno v:
Nucleic Acids Research. 51:D438-D444
The MobiDB database (URL: https://mobidb.org/) is a knowledge base of intrinsically disordered proteins. MobiDB aggregates disorder annotations derived from the literature and from experimental evidence along with predictions for all known protein se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e098be07bb56ab7eb3355a685bf60bd9
https://doi.org/10.1093/nar/gkac1065
https://doi.org/10.1093/nar/gkac1065
Autor:
Typhaine Paysan-Lafosse, Matthias Blum, Sara Chuguransky, Tiago Grego, Beatriz Lázaro Pinto, Gustavo A Salazar, Maxwell L Bileschi, Peer Bork, Alan Bridge, Lucy Colwell, Julian Gough, Daniel H Haft, Ivica Letunić, Aron Marchler-Bauer, Huaiyu Mi, Darren A Natale, Christine A Orengo, Arun P Pandurangan, Catherine Rivoire, Christian J A Sigrist, Ian Sillitoe, Narmada Thanki, Paul D Thomas, Silvio C E Tosatto, Cathy H Wu, Alex Bateman
Publikováno v:
Nucleic Acids Research. 51:D418-D427
The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. Here, we report recent developments with InterPro (v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153bbcbf1ab56d7f060b0d1aec9c1f19
https://doi.org/10.1093/nar/gkac993
https://doi.org/10.1093/nar/gkac993
Publikováno v:
Artificial Intelligence for Science ISBN: 9789811265662
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47adcba0fc070894c25ca84a19089ee1
https://doi.org/10.1142/9789811265679_0022
https://doi.org/10.1142/9789811265679_0022
