Tumor-Derived Extracellular Vesicles: Modulation of Cellular Functional Dynamics in Tumor Microenvironment and Its Clinical Implications

Autor: Nathalia Leal Santos, Silvina Odete Bustos, Darshak Bhatt, Roger Chammas, Luciana Nogueira de Sousa Andrade

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Cancer can be described as a dynamic disease formed by malignant and stromal cells. The cellular interaction between these components in the tumor microenvironment (TME) dictates the development of the disease and can be mediated by extracellular ves

Externí odkaz: https://doaj.org/article/093a972d89614bec8eb420193964b2ca

Galectin-3 determines tumor cell adaptive strategies in stressed tumor microenvironments

Autor: Ana Carolina Ferreira Cardoso, Luciana Nogueira de Sousa Andrade, Silvina Odete Bustos, Roger eChammas

Publikováno v: Frontiers in Oncology, Vol 6 (2016)

Galectin-3 is a member of the b-galactoside binding lectin family, whose expression is often dysregulated in cancers. While galectin-3 is usually an intracellular protein, found in the nucleus and in the cytoplasm; under certain conditions, galectin-

Externí odkaz: https://doaj.org/article/bab48b3ae8054ac2944b9ddb1b9ec089

Simultaneous silencing of lysophosphatidylcholine acyltransferases 1-4 by nucleic acid nanoparticles (NANPs) improves radiation response of melanoma cells

Autor: Morgan Chandler, Maria Cristina Rangel, Roger Chammas, Marcos Yukio Yoshinaga, Kirill A. Afonin, Adriano B. Chaves-Filho, Tatiane Katsue Furuya, Alexis Murillo Carrasco, Luciana Nogueira de Sousa Andrade, Silvina Odete-Bustos, Justin R. Halman, Renata F. Saito, Sayuri Miyamoto

Publikováno v: Nanomedicine
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Radiation induces the generation of platelet-activating factor receptor (PAF-R) ligands, including PAF and oxidized phospholipids. Alternatively, PAF is also synthesized by the biosynthetic enzymes lysophosphatidylcholine acyltransferases (LPCATs) wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee39f07a5be9554f35fa81baec8010b
https://doi.org/10.1016/j.nano.2021.102418

Interaction between omega 3 PUFA and UVB radiation: Photoprotective effect in normal and tumoral murine melanocytes?

Autor: Makely Daiane Barbosa, Ana Paula de Souza Votto, Camila Wink Soares, Roger Chammas, Silvina Odete Bustos, Gilma Santos Trindade, Juliana Ramos Gonzalez, Renata Ottes Vasconcelos

Publikováno v: Journal of Photochemistry and Photobiology B: Biology. 164:361-368

Omega 3 polyunsaturated fatty acids (omega 3 PUFA) are attracting a growing interest as potential adjuvants for cancer prevention and treatment. There is evidence about photoprotection in normal cells, but few previous studies have evaluated it in tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e78ec6109ecb2b2434bd79486c644eb
https://doi.org/10.1016/j.jphotobiol.2016.09.043

Reestablishment of p53/Arf and interferon-β pathways mediated by a novel adenoviral vector potentiates antiviral response and immunogenic cell death

Autor: Daniela B Zanatta, Thiago A. Salles, Eugenia Costanzi-Strauss, Paulo Roberto Del Valle, Aline Hunger, Tatiane Katsue Furuya, Silvina Odete Bustos, Renata de Freitas Saito, Bryan E. Strauss, Daniel G. Ferrari, Ruan Fv Medrano, Christian A. Merkel

Publikováno v: Cell Death Discovery
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Late stage melanoma continues to be quite difficult to treat and new therapeutic approaches are needed. Since these tumors often retain wild-type p53 and have a strong immunogenic potential, we developed a gene transfer approach which targets these c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4feacedc796e060bba04ae4bbcf2d7d2
https://doi.org/10.1038/cddiscovery.2017.17