Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

Autor: Eduardo Bergel, Alejandra Debonis, Ignacio Esteban, Sofia Jares Baglivo, Sofia Sol Aranda, Ramiro Manuel Larrea, Jorge Lantos, Nicolás Kreplak, Candela Etchegaray, Yvonne Ritou, Mabel Berrueta, Ricardo Valentini, Fernando Althabe, Pablo Cruz, Gabriel Leberzstein, Alvaro Ciganda, Sofia Lujan Laudanno, Damian Alvarez Paggi, Fernando Alvez, Susana Pastor Arguello, Luz Gibbons, Alejandra Hintze, M Laura Oyarvide, Clara Sanchez Yanotti, Miguel Santiago Gonzalez, Romina Libster, Gaston Ofman, Federico Cesar Etchenique, Rocio Lopez Castelo, Cristian Wood, Fernando P. Polack, Maria Dolores Silveyra, Alejandra Neira, Ivonne Name, Sebastian Esperante, Gisela Caruso, Nicolas Itcovici, Julian De Luca, Silvina Coviello, Anibal Rondan, Rocio Rodriguez, Valeria Fernandez Vina, Gabriela Lescano, Gonzalo Pérez Marc, Federico Dimase, Dario Raul Alvarez, Virginia Braem, Alejandra Bianchi, Julieta Alfonso, Sofia Rapelius, Adrián Ferreti, Eduardo Perez, Mauricio T. Caballero, Juan Molinos, Diego Wappner, Florencia Nowogrodzki

Publikováno v: New England Journal of Medicine
The New England Journal of Medicine
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

BACKGROUND: Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616e8d871c02399c474be2d5daf4bebf
https://doi.org/10.1056/nejmoa2033700

Respiratory Failure and Death in Vulnerable Premature Children With Lower Respiratory Tract Illness

Autor: Andrea Sancilio, Silvina Coviello, Gaston Ofman, Brad Pradarelli, Romina Libster, Eduardo Bergel, Mauricio T. Caballero, Fausto M Ferolla, Fernando Ferrero, Andrea Rodriguez, Patricio L. Acosta, Alejandra Bianchi, Luciano Alva Grimaldi, Adrian Ferretti, Fernando P. Polack, Karina Dueñas

Publikováno v: The Journal of Infectious Diseases

Background Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal lower respiratory tract infection (LRTI) in premature children in developing countries are necessary to elaborate evidenced-based preventive i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6955d9a6baa4f2e914b6bc2410470e
http://europepmc.org/articles/PMC7459133

Prevention of severe COVID-19 in the elderly by early high-titer plasma

Autor: Rocio Rodriguez, Mariano Girasolli, Viviana Dominguez, Valeria Fernandez Vina, Jorge Lantos, Florencia Nowogrodzki, Julian DeLuca, Sofia Lujan Laudanno, Clarisa Taffarel, Florencia Izetta, Maria del Carmen Nigro, Nicolás Kreplak, Fernando Alvez, Laura Oyarvide, Ivonne Ritou, Emmanuel Ezequiel Valls, Dario Raul Alvarez, Patricia Lesch, Indira Pichetto Olanda, Florencia De la Fuente, Camila Witteveen, Sebastian Esperante, Juan Rusconi, Sofia Sol Aranda, Juan Canela, Ricardo Valentini, Mauricio T. Caballero, Clara Sanchez Yanotti, Paula Fernandez Estrella, Gisela Caruso, Patricia Rearte Carvalho, Ramiro Manuel Larrea, Candela Etchegaray, Romina Libster, Cecilia Pampuro, Fernando P. Polack, Jose L Scapellato, Micaela Piani, Julieta Alfonso, Daniela Carolina Galnarez, Maria Eugenia Macaneo, Federico Dimase, Agustina Venditti, Juan Molinos, Cristina Soler Riera, Jimena Ochoa, Luz Gibbons, Eduardo Perez, Rocio Zarlenga, Alejandra Hintze, Guido Ochoa, Damian Alvarez Paggi, Silvina Kuperman, Virginia Braem, Mariano Aizpurua, Alfonso Raggio, Miguel Santiago Gonzalez, Maria Teresa Paniguetti, Maria Fernanda Caracciolo, Gabriela Lescano, Juan Mauricio Vargas, Silvina Coviello, Fernando Althabe, Sofia Jarez Baglivo, Juan Sebastian Riera, Anibal Rondan, Mario Rovere, Gaston Pellegrino, Nicolas Itcovici, Yanina Miragaya, Alejandra Neira, Carla Marchionatti, Silvana Marquez, Maria Emilia Gutierrez Meyer, Gonzalo Pérez Marc, Marcela Balduzzi, Lia Pocket, Mabel Berrueta, Romina Zadoff, Noelia Iraizos, Susana Villaroel, Eduardo Bergel, Rocio Lopez Castelo, Maria Veronica Paz, Maria Dolores Silveyra, Maximiliano de Zan, Agostina Pagella, Lucila DiNunzio, Jimena Franco, Romina Militerno, Natalia Garcia Escude, Gabriela Leberzstein, Diego Wappner, Pablo Cruz, Romina Romero, Jorge Geffner, Susana Pastor Arguello, Leonel Langellotti, Andrea V. Gamarnik, Alejandra Debonis, Ignacio Esteban, Gaston Ofman, Federico Cesar Etchenique, Cristian Wood, Ivonne Name, Natali Estrada, Sebastian Perez Marc, Enio Garcia, Sofia Rapelius, Alvaro Ciganda, Alejandra Bianchi, Adrian Ferretti

BackgroundTherapies to interrupt progression of early COVID-19 remain elusive. Among them, convalescent plasma in hospitalized patients was unsuccessful, perhaps because antibody should be administered earlier. We advanced plasma infusions to the fir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c61488b24349c934e8ad0ee3572275f
https://doi.org/10.1101/2020.11.20.20234013

Bacterial lysates improve the protective antibody response against respiratory viruses through Toll-like receptor 4

Autor: Fernando P. Polack, Silvina Coviello, Pablo M. Irusta, Vera Wimmenauer

Publikováno v: Human Vaccines & Immunotherapeutics. 10:2896-2902

Respiratory viruses cause significant morbidity and mortality in infants and young children worldwide. Current strategies to modulate the immune system and prevent or treat respiratory viral infections in this age group have shown limited success. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d5173a792bba991f7d4da717d8f7a3
https://doi.org/10.4161/hv.29784

Breastfeeding is associated with the production of type I interferon in infants infected with influenza virus

Autor: Johanna Zea-Hernandez, Niranjan Bhat, Fausto M Ferolla, Silvina Coviello, Fernando P. Polack, Guillermina A. Melendi

Publikováno v: Acta Paediatrica. 99:1517-1521

Background: Breast milk-mediated protection against respiratory viruses is well established. However, protective mechanisms are unclear. Type I interferons (IFN) mediate host defence against respiratory viruses, particularly influenza virus. The rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca1abf808035caaa78f0764d58d41cb3
https://doi.org/10.1111/j.1651-2227.2010.01862.x