Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Silvia Zucchelli"'
Autor:
Casimiro Luca Gigliotti, Elena Boggio, Francesco Favero, Danny Incarnato, Claudio Santoro, Salvatore Oliviero, Josè Maria Rojo, Silvia Zucchelli, Francesca Persichetti, Gianluca Baldanzi, Umberto Dianzani, Davide Corà
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Costimulatory molecules of the CD28 family play a crucial role in the activation of immune responses in T lymphocytes, complementing and modulating signals originating from the T-cell receptor (TCR) complex. Although distinct functional roles have be
Externí odkaz:
https://doaj.org/article/55eb914dee7e467a8a6a4d3d915b6074
Autor:
Mara Gagliardi, Nausicaa Clemente, Romina Monzani, Luca Fusaro, Eleonora Ferrari, Valentina Saverio, Giovanna Grieco, Elżbieta Pańczyszyn, Flavia Carton, Claudio Santoro, Sara Del Mare-Roumani, Sivan Amidror, Nissan Yissachar, Francesca Boccafoschi, Silvia Zucchelli, Marco Corazzari
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Celiac disease (CD) is a complex immune-mediated chronic disease characterized by a consistent inflammation of the gastrointestinal tract induced by gluten intake in genetically predisposed individuals. Although initiated by the interaction
Externí odkaz:
https://doaj.org/article/6d68940d7e6942889c1d1acb6068e810
Autor:
Francesco Favero, Elettra Barberis, Mara Gagliardi, Stefano Espinoza, Liliana Contu, Stefano Gustincich, Francesca Boccafoschi, Chiara Borsotti, Dmitry Lim, Vito Rubino, Flavio Mignone, Edoardo Pasolli, Marcello Manfredi, Silvia Zucchelli, Davide Corà, Marco Corazzari
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273036 (2022)
The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases suc
Externí odkaz:
https://doaj.org/article/c40b8a03dbf94ef99e0b6716b4960b25
Autor:
Gloria Ros, Silvia Pegoraro, Paolo De Angelis, Riccardo Sgarra, Silvia Zucchelli, Stefano Gustincich, Guidalberto Manfioletti
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
Background: Natural antisense long non-coding RNAs (lncRNAs) are regulatory RNAs transcribed from the opposite strand of either protein coding or non-coding genes, able to modulate their own sense gene expression. Hence, their dysregulation can lead
Externí odkaz:
https://doaj.org/article/def8e49588804025bc77ccc6ba1a2414
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 14, Iss C, Pp 404-410 (2016)
Mammalian cells are an indispensable tool for the production of recombinant proteins in contexts where function depends on post-translational modifications. Among them, Chinese Hamster Ovary (CHO) cells are the primary factories for the production of
Externí odkaz:
https://doaj.org/article/d70de93169fb40c885c1f0f4d3b57d23
Autor:
Hazuki Takahashi, Ana Kozhuharova, Harshita Sharma, Masakazu Hirose, Takako Ohyama, Francesca Fasolo, Toshio Yamazaki, Diego Cotella, Claudio Santoro, Silvia Zucchelli, Stefano Gustincich, Piero Carninci
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0183229 (2018)
SINEUPs are antisense long noncoding RNAs, in which an embedded SINE B2 element UP-regulates translation of partially overlapping target sense mRNAs. SINEUPs contain two functional domains. First, the binding domain (BD) is located in the region anti
Externí odkaz:
https://doaj.org/article/c97deee961594180b4f5b1535889a7a8
Autor:
Sandra Vilotti, Marta Codrich, Marco Dal Ferro, Milena Pinto, Isidro Ferrer, Licio Collavin, Stefano Gustincich, Silvia Zucchelli
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35051 (2012)
Mutations in PARK7/DJ-1 gene are associated to autosomal recessive early onset forms of Parkinson's disease (PD). Although large gene deletions have been linked to a loss-of-function phenotype, the pathogenic mechanism of missense mutations is less c
Externí odkaz:
https://doaj.org/article/4c2bbae141594ad28abdbc2dd8f3d3fa
Autor:
Matthew N. Z. Valentine, Piero Carninci, Hazuki Takahashi, Naoko Toki, Silvia Zucchelli, Harshita Sharma, Ferdous-Ur M Rahman, Stefano Gustincich
Publikováno v:
Nucleic Acids Research
SINEUPs are long non-coding RNAs (lncRNAs) that contain a SINE element, and which up-regulate the translation of target mRNA. They have been studied in a wide range of applications, as both biological and therapeutic tools, although the underpinning
Publikováno v:
Nucleic Acids Research
Solution nuclear magnetic resonance (NMR) experiments allow RNA dynamics to be determined in an aqueous environment. However, when a limited number of peaks are assigned, it is difficult to obtain structural information. We here show a protocol based
Autor:
Valentina Bruscaggin, Silvia Zucchelli, Ester Borroni, Diego Zanolini, Rosella Famà, Simone Merlin, Antonia Follenzi
Publikováno v:
Blood Advances. 3:825-838
Here we describe a successful gene therapy approach for hemophilia A (HA), using the natural F8 promoter (pF8) to direct gene replacement to factor VIII (FVIII)–secreting cells. The promoter sequence and the regulatory elements involved in the modu