Výsledky vyhledávání - "Silvia Tortola"

The Rate of c-fos Transcription in Vivo Is Continuously Regulated at the Level of Elongation by Dynamic Stimulus-coupled Recruitment of Positive Transcription Elongation Factor b

Autor: Silvia Tortola, Isabelle Piuz, Werner Schlegel, Stephan Ryser, Toshitsugu Fujita

Publikováno v: Journal of Biological Chemistry. 282:5075-5084

In mammalian cells, multiple stimuli induce the expression of the immediate early gene c-fos. The specificity of c-fos transcriptional response depends on the activation of signaling protein kinases, transcription factors, and chromatin-modifying com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d93470041944eaebf61b57dc362993b
https://doi.org/10.1074/jbc.m607847200

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Gene-specific recruitment of positive and negative elongation factors during stimulated transcription of the MKP-1 gene in neuroendocrine cells

Autor: Silvia Tortola, Werner Schlegel, Isabelle Piuz, Toshitsugu Fujita, Stephan Ryser

Publikováno v: Nucleic Acids Research

MAP kinase phosphatase-1 (MKP-1) controls nuclear MAP kinase activity with important consequences on cell growth or apoptosis. MKP-1 transcription is initiated constitutively but elongation is blocked within exon 1. It is unclear how induction of MKP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a7e92e2083177b622e215a1b001c49
http://europepmc.org/articles/PMC1807974

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MAP Kinase Phosphatase-1 Gene Transcription in Rat Neuroendocrine Cells Is Modulated by a Calcium-sensitive Block to Elongation in the First Exon

Autor: Goedele van Haasteren, Senlin Li, Silvia Tortola, Marco Muda, Werner Schlegel, Stephan Ryser

Publikováno v: Journal of Biological Chemistry. 276:33319-33327

Transcriptional elongation of many eukaryotic, prokaryotic, and viral genes is tightly controlled, which contributes to gene regulation. Here we describe this phenomenon for the MAP kinase phosphatase 1 (MKP-1) immediate early gene. In rat GH4C1 pitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd8bdabad1ea0dbc635b09cc59106b4
https://doi.org/10.1074/jbc.m102326200

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Map kinase phosphatase-1 gene expression and regulation in neuroendocrine cells

Autor: Werner Schlegel, Silvia Tortola, Stephan Ryser

Publikováno v: Journal of receptor and signal transduction research. 22(1-4)

Long-term cellular processes like proliferation, differentiation, and adaptive responses (e.g. neuronal plasticity) are initiated by the synthesis of immediate early gene (IEG) products which control the expression of late response genes. Immediate e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aea6222591e7e95e0d29673251542e5
https://pubmed.ncbi.nlm.nih.gov/12503606

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Accuracy of two-dimensional electrophoresis for target discovery in human colorectal cancer

Autor: M. A. Reymond, Bettina Borisch, R Steinert, Vincent Olivier Ott, Silvia Tortola, K Guenther, Werner Schlegel

Publikováno v: The Pharmacogenomics Journal, Vol. 1, No 2 (2001) pp. 142-51

Two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) is increasingly used for target discovery in human disease to complement genomic studies. We have assessed the possibilities and limits of 2-D PAGE applied to human colorectal cancer. Up t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1dc114b9cbcd4dfc2448fe04cbe3519
https://pubmed.ncbi.nlm.nih.gov/11911441

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Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer

Autor: Marc A. Reymond, Hans Lippert, Werner Schlegel, Miguel A. Peinado, Peter Stosiek, Ralf Steinert, M. Hantschick, Silvia Tortola, Ingo Gastinger

Publikováno v: Europe PubMed Central

PURPOSE: To study bone marrow micrometastases from colorectal cancer patients for the presence of K-ras mutations and to compare their genotype with that of the corresponding primary tumor. PATIENTS AND METHODS: Bilateral iliac crest aspiration was p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2331d849734465ca43f728a9600e9e
https://pubmed.ncbi.nlm.nih.gov/11387355

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Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis

Autor: Miguel A. Peinado, Marc A. Reymond, Denis F. Hochstrasser, Graham J. Hughes, J Riese, Thomas Kirchner, Jean-Charles Sanchez, Klaus Günther, Ferdinand Köckerling, Silvia Tortola, Werner Hohenberger

Publikováno v: Electrophoresis. 18(15)

New diagnostic and prognostic markers are needed in colorectal cancer. They can be found by differential analysis at DNA, RNA or protein level. The accuracy of phenotypic comparisons of tumor and normal tissues depends on the purity of the samples. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789241af23353c7a6a2deed8d1d3e24a
https://pubmed.ncbi.nlm.nih.gov/9504818

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Specific sample preparation in colorectal cancer

Autor: Claus Schneider, Jean-Charles Sanchez, Ferdinand Köckerling, Werner Hohenberger, Peter Rohwer, Denis F. Hochstrasser, Silvia Tortola, Marc A. Reymond, Thomas Kirchner

Publikováno v: Electrophoresis. 18(3-4)

Large tissue samples from ten patients operated for colorectal cancer were prepared in the operating room in iced phosphate buffered saline, containing ethylene diaminetetraacetic acid and protease inhibitors. After cutting the specimens into small f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029ab1559f8c7c9f2ec4f00468cdfd7d
https://pubmed.ncbi.nlm.nih.gov/9150950

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