Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Silvia T. Cardona"'
Autor:
Dustin T. Maydaniuk, Brielle Martens, Sarah Iqbal, Andrew M. Hogan, Neil Lorente Cobo, Anna Motnenko, Dang Truong, Sajani H. Liyanage, Mingdi Yan, Gerd Prehna, Silvia T. Cardona
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTDrug repurposing efforts led to the discovery of bactericidal activity in auranofin, a gold-containing drug used to treat rheumatoid arthritis. Auranofin kills Gram-positive bacteria by inhibiting thioredoxin reductase, an enzyme that scaveng
Externí odkaz:
https://doaj.org/article/1a6ae9ac46584d42a3eb3d1a16ac8dea
Autor:
Andrew M. Hogan, A. S. M. Zisanur Rahman, Anna Motnenko, Aakash Natarajan, Dustin T. Maydaniuk, Beltina León, Zayra Batun, Armando Palacios, Alejandra Bosch, Silvia T. Cardona
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The cell envelope of Gram-negative bacteria belonging to the Burkholderia cepacia complex (Bcc) presents unique restrictions to antibiotic penetration. As a consequence, Bcc species are notorious for causing recalcitrant multidrug-resistant
Externí odkaz:
https://doaj.org/article/e75ea8b5840542578185833f4513f01c
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Graph convolutional neural networks (GCNs) have been repeatedly shown to have robust capacities for modeling graph data such as small molecules. Message-passing neural networks (MPNNs), a group of GCN variants that can learn and aggregate lo
Externí odkaz:
https://doaj.org/article/5568317c8b3a4f7da809d8c0815ca27e
Publikováno v:
BMC Bioinformatics, Vol 23, Iss S4, Pp 1-21 (2022)
Abstract Background Converting molecules into computer-interpretable features with rich molecular information is a core problem of data-driven machine learning applications in chemical and drug-related tasks. Generally speaking, there are global and
Externí odkaz:
https://doaj.org/article/7f8110e1c03a42cd9a0e4b5fcffa09db
Autor:
Chengyou Liu, Andrew M. Hogan, Hunter Sturm, Mohd Wasif Khan, Md. Mohaiminul Islam, A. S. M. Zisanur Rahman, Rebecca Davis, Silvia T. Cardona, Pingzhao Hu
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Motivation Chemical–genetic interaction profiling is a genetic approach that quantifies the susceptibility of a set of mutants depleted in specific gene product(s) to a set of chemical compounds. With the recent advances in artificial inte
Externí odkaz:
https://doaj.org/article/5631e85a7daa4295b43b4e0a14be011b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract A first clue to gene function can be obtained by examining whether a gene is required for life in certain standard conditions, that is, whether a gene is essential. In bacteria, essential genes are usually identified by high-density transpos
Externí odkaz:
https://doaj.org/article/ef606ed9597843aea979e28516c3d169
Autor:
Anna J. Hooppaw, Jenna C. McGuffey, Gisela Di Venanzio, Juan C. Ortiz-Marquez, Brent S. Weber, Tasia Joy Lightly, Tim van Opijnen, Nichollas E. Scott, Silvia T. Cardona, Mario F. Feldman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT The opportunistic pathogen Acinetobacter baumannii is responsible for a wide range of infections that are becoming increasingly difficult to treat due to extremely high rates of multidrug resistance. Acinetobacter’s pathogenic potential is
Externí odkaz:
https://doaj.org/article/30f123d366be48099dc72ea13e663c47
Autor:
Dustin Maydaniuk, Bin Wu, Dang Truong, Sajani H. Liyanage, Andrew M. Hogan, Zhong Ling Yap, Mingdi Yan, Silvia T. Cardona
Publikováno v:
Antibiotics, Vol 10, Iss 12, p 1443 (2021)
Bacteria of the genus Burkholderia include pathogenic Burkholderia mallei, Burkholderia pseudomallei and the Burkholderia cepacia complex (Bcc). These Gram-negative pathogens have intrinsic drug resistance, which makes treatment of infections difficu
Externí odkaz:
https://doaj.org/article/0f95b848f6b74c7083c4a433dfc31cfb
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Burkholderia cenocepacia is an opportunistic bacterium that can thrive in different environments, including the amino acid-rich mucus of the cystic fibrosis (CF) lung. B. cenocepacia responds to the nutritional conditions that mimic the CF sputum by
Externí odkaz:
https://doaj.org/article/d9ef5c1c5bd34856bfd9a677cbd31240
Autor:
Jaroslav Nunvar, Andrew M. Hogan, Silvia Buroni, Svetlana Savina, Vadim Makarov, Silvia T. Cardona, Pavel Drevinek
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 159 (2019)
Bacteria of the Burkholderia cepacia complex (Bcc) are associated with significant decline of lung functions in cystic fibrosis patients. Bcc infections are virtually impossible to eradicate due to their irresponsiveness to antibiotics. The 2-thiocya
Externí odkaz:
https://doaj.org/article/6052ffe320b6418ca17e1a26f7476200