Výsledky vyhledávání - "Silvia Stabel"

Clarification of the Binding Mode of Teleocidin and Benzolactams to the Cys2 Domain of Protein Kinase Cδ by Synthesis of Hydrophobically Modified, Teleocidin-Mimicking Benzolactams and Computational Docking Simulation

Autor: Michihiro Ohno, Koichi Shudo, Silvia Stabel, Yasuyuki Endo, Paul E. Driedger, Shunji Takehana, Akiko Itai, Nobuo Tomioka, Miho Mizutani

Publikováno v: Journal of Medicinal Chemistry. 41:1476-1496

Phorbol esters (12-O-tetradecanoylphorbol 13-acetate; TPA) and teleocidins are known to be potent tumor promoters and to activate protein kinase C (PKC) by binding competitively to the enzyme. The relationship between the chemical structures and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5b2536bde73c322a20f8bccebe399c
https://doi.org/10.1021/jm970704s

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Novel conformationally constrained analogues of diacylglycerol. Protein kinase C binding affinity of simplified compounds based on a 6-membered lactam moiety

Autor: Koichi Shudo, Silvia Stabel, Masaaki Hirano, Yasuyuki Endo, Paul E. Driedger

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2997-3000

Four configurational isomers of 6-hydroxymethyl-3-isopropyl-4-tetradecylpiperazin-2-ones (4–7), which were designed based on information obtained from the biologically active conformation of teleocidins and benzolactams, were synthesized and evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c75efec4fe5a2c5540bc96bfd219818
https://doi.org/10.1016/s0960-894x(97)10129-9

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Activation of protein kinase C subtypes α, γ, δ, ϵ, ζ, and η by tumor-promoting and nontumor-promoting agents

Autor: Josef Pfeilschifter, Mirka Vanek, Detlef Geiges, Thomas Meyer, Georges Weissgerber, Doriano Fabbro, Andrea Huwiler, Silvia Stabel, Barbara M. Marte

Publikováno v: Biochemical Pharmacology. 53:865-875

Protein kinase C (PKC) subtypes alpha, gamma, delta, epsilon, zeta, and eta have been expressed using the baculovirus expression system. The partially purified PKC subtypes have been studied for their substrate specificities and phospholipid-independ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::253669b6a8355ed064d0a1816b0c745a
https://doi.org/10.1016/s0006-2952(96)00885-4

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Immunodeficiency in Protein Kinase Cβ-Deficient Mice

Autor: Jean Davoust, Christian Schmedt, Rodolphe Guinamard, Silvia Stabel, Alexander Tarakhovsky, Stefan Schaal, Michael Leitges

Publikováno v: Science
Science, American Association for the Advancement of Science, 1996, 273 (5276), pp.788-791. ⟨10.1126/science.273.5276.788⟩
Science, 1996, 273 (5276), pp.788-791. ⟨10.1126/science.273.5276.788⟩

Cross-linking of the antigen receptor on lymphocytes by antigens or antibodies to the receptor results in activation of enzymes of the protein kinase C (PKC) family. Mice homozygous for a targeted disruption of the gene encoding the PKC-betaI and PKC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e0153b70a8ebf9757720aba53c7882
https://doi.org/10.1126/science.273.5276.788

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Soluble Human Interleukin-6 Receptor. Expression in Insect Cells, Purification and Characterization

Autor: Gerhard Müller-Newen, Peter Kurschat, Peter C. Heinrich, Ulrike Hemmann, Andrea Küster, M. Hart, Just P. J. Brakenhoff, Silvia Stabel, Stefan Rose-John, Oliver H. Weiergräber, Johannes Schneider

Publikováno v: European Journal of Biochemistry. 234:661-669

The extracellular domain of the human interleukin-6 (IL-6) receptor, comprising 339 amino acids following the signal peptide, has been expressed in baculovirus-infected insect cells (Sf158). When the soluble receptor secreted into the culture medium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2334753722fbbe63b26096940c9efa92
https://doi.org/10.1111/j.1432-1033.1995.661_b.x

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Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

Autor: Simon Lovestone, C.Hugh Reynolds, Donna Latimer, Daniel R. Davis, Brian H. Anderton, Jean-Marc Gallo, Diane Hanger, Sandrine Mulot, Betina Marquardt, Silvia Stabel, James R. Woodgett, Christopher C.J. Miller

Publikováno v: Current Biology. 4:1077-1086

Background: Paired helical filaments (PHFs) are a characteristic pathological feature of Alzheimer's disease; their principal component is the microtubule-associated protein tau. The tau in PHFs (PHF-tau) is hyperphosphorylated, but the cellular mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accb8b66408aa3b952eadc12b29ea7bf
https://doi.org/10.1016/s0960-9822(00)00246-3

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Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C

Autor: Agneta Siegbahn, Peter Blume-Jensen, Silvia Stabel, Carl-Henrik Heldin, Lars Rönnstrand

Publikováno v: The EMBO Journal. 12:4199-4209

The product of the c-kit proto-oncogene, denoted Kit/SCF-R, encodes a tyrosine kinase receptor for stem cell factor (SCF). Kit/SCF-R induces proliferation, differentiation or migration of cells within the hematopoietic, gametogenic and melanogenic li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bace5fce6b29d4a7573cc2abfb149aa8
https://doi.org/10.1002/j.1460-2075.1993.tb06104.x

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Protein kinase C group B members PKC-δ, -ɛ, -ζ and PKC-L(η). Comparison of properties of recombinant proteins in vitro and in vivo

Autor: Marek Liyanage, David Frith, Silvia Stabel, Etta Livneh

Publikováno v: Biochemical Journal. 283:781-787

Of the recently identified protein kinase C (PKC) types of group B (delta, epsilon, zeta, eta, PKC-L), only PKC-epsilon has been characterized in great detail. In order to compare the regulatory and catalytic properties of these new kinases, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bf134e3efa6a4844bc042c6cad37a10
https://doi.org/10.1042/bj2830781

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Interaction of protein kinase C ζ with ZIP, a novel protein kinase C-binding protein

Autor: Ferdi Grawe, Sandra Schmidt, Silvia Stabel, Axel Puls

The atypical protein kinase C (PKC) member PKC-ζ has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells. We report here the identification of a cytoplasmic and membrane-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2648c5de3603076cd25c5cd88c1512
https://europepmc.org/articles/PMC21025/

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