Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Silvia Sposini"'
Autor:
Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco V. Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Long-term depression (LTD) of synaptic strength contributes to circuit remodeling, memory encoding and erasure. Here, the authors show that P2XR- and NMDAR-dependent LTD are associated with distinct and precise molecular modifications that lead to sp
Externí odkaz:
https://doaj.org/article/42d7f0f08a7745138e490a7bf976a87f
Autor:
Morgane Rosendale, Thi Nhu Ngoc Van, Dolors Grillo-Bosch, Silvia Sposini, Léa Claverie, Isabel Gauthereau, Stéphane Claverol, Daniel Choquet, Matthieu Sainlos, David Perrais
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
During clathrin mediated endocytosis (CME), membrane scission is achieved by the concerted action of dynamin and its interacting partners such as amphiphysins. Here authors show that efficient recruitment and function of dynamin requires simultaneous
Externí odkaz:
https://doaj.org/article/ba6e9aee54e54df3b3011ac958eab9c6
Autor:
Silvia Sposini, Francesco De Pascali, Rachel Richardson, Niamh S. Sayers, David Perrais, Henry N. Yu, Stephen Palmer, Selva Nataraja, Eric Reiter, Aylin C. Hanyaloglu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. One key mechanism dictating the signal activity of GPCRs is membrane trafficking. After binding its hormone FSH, FSHR undergoes in
Externí odkaz:
https://doaj.org/article/e23f5dba43fd4c0eb3ef91dc52330195
Autor:
Caroline M. Gorvin, Angela Rogers, Benoit Hastoy, Andrei I. Tarasov, Morten Frost, Silvia Sposini, Asuka Inoue, Michael P. Whyte, Patrik Rorsman, Aylin C. Hanyaloglu, Gerda E. Breitwieser, Rajesh V. Thakker
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 1054-1066 (2018)
Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles
Externí odkaz:
https://doaj.org/article/a620aa50861b4760af796663dffcd895
Autor:
Silvia Sposini, Frederic G. Jean-Alphonse, Mohammed A. Ayoub, Affiong Oqua, Camilla West, Stuart Lavery, Jan J. Brosens, Eric Reiter, Aylin C. Hanyaloglu
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2855-2867 (2017)
Summary: Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity to be spatially rest
Externí odkaz:
https://doaj.org/article/ed50dbb194264e8e94d6b99f22063168
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::080397908ea2f08b5ec815ba7f5f81c2
https://doi.org/10.1530/endoabs.86.p124
https://doi.org/10.1530/endoabs.86.p124
Autor:
Domenico Azarnia Tehran, Gaga Kochlamazashvili, Niccolò P. Pampaloni, Silvia Sposini, Jasmeet Kaur Shergill, Martin Lehmann, Natalya Pashkova, Claudia Schmidt, Delia Löwe, Hanna Napieczynska, Arnd Heuser, Andrew J. R. Plested, David Perrais, Robert C. Piper, Volker Haucke, Tanja Maritzen
Publikováno v:
Science Advances. 8
AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission, and the plastic modulation of their surface levels determines synaptic strength. AMPARs of different subunit compositions fulfill distinct roles in synaptic long-term p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4d9011c8f20aa93dd5c21c8a7491d0
https://doi.org/10.1126/sciadv.abl5032
https://doi.org/10.1126/sciadv.abl5032
Autor:
Punita Kumari, Debarati Roy, Madhu Chaturvedi, Arun K. Shukla, Hemlata Dwivedi-Agnihotri, Shubhi Pandey, Aylin C. Hanyaloglu, Ashish Srivastava, Michel Bouvier, Silvia Sposini, Badr Sokrat, Mithu Baidya
Publikováno v:
J Biol Chem
Agonist stimulation of G protein-coupled receptors (GPCRs) typically leads to phosphorylation of GPCRs and binding to multifunctional proteins called β-arrestins (βarrs). The GPCR-βarr interaction critically contributes to GPCR desensitization, en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e658d55fc514152e603322d1ac26d5d
https://doi.org/10.1074/jbc.ra120.013470
https://doi.org/10.1074/jbc.ra120.013470
Publikováno v:
Methods in cell biology. 166
Arrestins are key proteins that serve as versatile scaffolds to control and mediate G protein coupled receptors (GPCR) activity. Arrestin control of GPCR functions involves their recruitment from the cytosol to plasma membrane-localized GPCRs and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce1bf98b8259c1eebbd32ad09b1bc01a
https://pubmed.ncbi.nlm.nih.gov/34752332
https://pubmed.ncbi.nlm.nih.gov/34752332
Autor:
Aylin C. Hanyaloglu, Silvia Sposini
Publikováno v:
Reproduction. 156:R195-R208
Our understanding of G protein-coupled receptor (GPCR) signalling has significantly evolved over the past decade, whereby signalling not only occurs from the plasma membrane but continues, or is reactivated, following internalisation in to endosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31865e6016684948e075b81c9d441e07
https://doi.org/10.1530/rep-18-0423
https://doi.org/10.1530/rep-18-0423