Discovery and characterization of heterogeneous and multipotent fibroblast populations isolated from excised cleft lip tissue

Autor: Ludovica Parisi, Silvia Rihs, Giorgio C. La Scala, Isabelle Schnyder, Christos Katsaros, Martin Degen

Publikováno v: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2022)

Abstract Background Regularly discarded lip tissue obtained from corrective surgeries to close the cleft lip represents an easily accessible and rich source for the isolation of primary fibroblasts. Primary fibroblasts have been described to show com

Externí odkaz: https://doaj.org/article/67dd0e34ffc04a9cb98c5af609e062a3

Lack of IRF6 Disrupts Human Epithelial Homeostasis by Altering Colony Morphology, Migration Pattern, and Differentiation Potential of Keratinocytes

Autor: Eleftheria Girousi, Lukas Muerner, Ludovica Parisi, Silvia Rihs, Stephan von Gunten, Christos Katsaros, Martin Degen

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Variants within the gene encoding for the transcription factor Interferon Regulatory Factor 6 (IRF6) are associated with syndromic and non-syndromic Cleft Lip/Palate (CLP) cases. IRF6 plays a vital role in the regulation of the proliferation/differen

Externí odkaz: https://doaj.org/article/7c5b3e273a6b4e3d8799c298d51d1e16

TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis

Autor: Daniel Zysset, Benjamin Weber, Silvia Rihs, Jennifer Brasseit, Stefan Freigang, Carsten Riether, Yara Banz, Adelheid Cerwenka, Cedric Simillion, Pedro Marques-Vidal, Adrian F. Ochsenbein, Leslie Saurer, Christoph Mueller

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)

TREM-1 is a receptor that amplifies acute pro-inflammatory responses in infection. Here the authors show that TREM-1 plays an important role in atherosclerosis, a chronic and non-infectious disease, by critically skewing myelopoiesis towards preferen

Externí odkaz: https://doaj.org/article/c98d1cb4aaf840bdbe679de4d5413ba5

TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance.

Autor: Benjamin Weber, Steffen Schuster, Daniel Zysset, Silvia Rihs, Nina Dickgreber, Christian Schürch, Carsten Riether, Mark Siegrist, Christoph Schneider, Helga Pawelski, Ursina Gurzeler, Pascal Ziltener, Vera Genitsch, Fabienne Tacchini-Cottier, Adrian Ochsenbein, Willy Hofstetter, Manfred Kopf, Thomas Kaufmann, Annette Oxenius, Walter Reith, Leslie Saurer, Christoph Mueller

Publikováno v: PLoS Pathogens, Vol 10, Iss 1, p e1003900 (2014)

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune reactions. While TREM-1-amplified responses likely aid an improved detection and elimination of pathogens, excessive production of cytok

Externí odkaz: https://doaj.org/article/42262ea844a64ff3b8f92dc971b3e0fb

TREM-1 promotes intestinal tumorigenesis

Autor: Leslie Saurer, Daniel Zysset, Christoph Mueller, Philippe Krebs, Silvia Rihs, Cedric Simillion, Inti Zlobec, Matteo Gusberti, Lukas F. Mager, Alessandro Lugli

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Saurer, Leslie; Zysset, Daniel; Rihs, Silvia; Mager, Lukas; Gusberti, Matteo; Simillion, Cedric; Lugli, Alessandro; Zlobec, Inti; Krebs, Philippe; Müller, Christoph (2017). TREM-1 promotes intestinal tumorigenesis. Scientific Reports, 7(1), p. 14870. Nature Publishing Group 10.1038/s41598-017-14516-4

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune responses. Increasing evidence suggests a role for TREM-1 not only in acute pathogen-induced reactions but also in chronic and non-infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3729dc3dc362819173e51969398d887e
http://link.springer.com/article/10.1038/s41598-017-14516-4