Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Silvia Regina Graziani"'
1
Safety and Efficacy of PTCTS Cosmetic Gel: Study on Human Radiodermatitis Lesions
Autor: Carlos Elias Fristachi, Maria de Lourdes Higuchi, Brigitte M. Van Eyll, Renata N Ikegami, José Antonio Franchini Ramires, Silvia Regina Graziani
Publikováno v: Case Reports in Clinical Medicine. :327-333
Radiodermatitis is a constant complication after radiotherapy with no efficient drug for prevention and treatment. Its physiopathology is complex, possibly related to injury of epidermis and endothelial cells from the basal layer by radiolysis, overp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5091ab12553225a8ba8ed79e18b1e68
https://doi.org/10.4236/crcm.2015.410065
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2
Phase II study of paclitaxel associated with lipid core nanoparticles (LDE) as third-line treatment of patients with epithelial ovarian carcinoma
Autor: Silvia Regina Graziani, Brigitte M. Van Eyll, Aleksandra Tiemi Morikawa, Roberto Kalil Filho, Carolina Graziani Vital, Raul C. Maranhão, Hézio Jadir Fernandes Júnior
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Ovarian cancer is often diagnosed at advanced stages, when poorly responsive to standard treatment. First-line treatment consists in schemes including cytoreductive surgery followed by adjuvant chemotherapy schemes with platinum and taxane derivative
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2512db1af51355d704ee5e81243f8c0a
https://pubmed.ncbi.nlm.nih.gov/28756613
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3
Clinical experience with drug delivery systems as tools to decrease the toxicity of anticancer chemotherapeutic agents
Autor: Silvia Regina Graziani, Thauany M Tavoni, Raul C. Maranhão, Carolina Graziani Vital
Publikováno v: Expert opinion on drug delivery. 14(10)
The toxicity of chemotherapeutic agents, resulting from their low pharmacological index, introduces considerable discomfort and risk to cancer patients. Among several strategies to reduce the toxicity of chemotherapeutic agents, targeted drug deliver
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7680ef43074d5d031b9756aefe5486
https://pubmed.ncbi.nlm.nih.gov/28042707
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4
Uptake of a Cholesterol-Rich Emulsion by Breast Cancer
Autor: Laura I. Brandizzi, Roberto Hegg, José Aristodemo Pinotti, Fernando Antônio Ferreira da Igreja, Rosângela F. Amâncio, Claudio Meneghetti, Raul C. Maranhão, Renato Barboza, Silvia Regina Graziani
Publikováno v: Gynecologic Oncology. 85:493-497
Objective. Overexpression of low-density lipoprotein (LDL) receptors occurs in several cancer cell lines and offers a unique strategy for drug targeting by using LDL as vehicle. However, the native lipoprotein is difficult to obtain and handle. Previ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2056c48946e85bb07fa55f3fe11449
https://doi.org/10.1006/gyno.2002.6654
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5
Association of carmustine with a lipid emulsion: in vitro, in vivo and preliminary studies in cancer patients
Autor: Roberto F. Melo, Antonio C. Buzaid, Silvia Regina Graziani, Raul C. Maranhão, Ricardo David Couto, Maria C. Latrilha, Nise Hitomi Yamaguchi, Debora C. Rodrigues, Shirley Schreier
Publikováno v: Cancer Chemotherapy and Pharmacology. 49:487-498
Purpose: We had previously shown in acute leukemia and in breast and ovary carcinoma patients that a cholesterol-rich emulsion (LDE) that binds to receptors for low-density lipoprotein (LDL) may concentrate in neoplastic tissues. In this study, the p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb01d831d6381c13808b0baceea6c89
https://doi.org/10.1007/s00280-002-0437-3
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8
Uptake of a Cholesterol-Rich Emulsion by Neoplastic Ovarian Tissues
Autor: José Aristodemo Pinotti, Raul C. Maranhão, Silvia Regina Graziani, Alexandre Ades, Rosângela F. Amancio, Jorge Saad Souen, Jesus Paula Carvalho
Publikováno v: Gynecologic Oncology. 82:84-87
Previously, it was shown that a lipidic emulsion (LDE) composed of phospholipids and cholesterol esters which binds to low-density lipoprotein (LDL) receptors may concentrate in acute myeloid leukemia cells. In this study, we aimed to verify whether
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00417265340f86c0468b4979222964de
https://doi.org/10.1006/gyno.2001.6203
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10
Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study
Autor: Silvia Regina Graziani, Debora G. Rodrigues, Claudete J. Valduga, Roberto Hegg, Raul C. Maranhão, L. A. Pires
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
In animal experiments paclitaxel oleate associated with a cholesterol-rich nanoemulsion concentrated in the neoplastic tissues and showed reduced toxicity and increased antitumor activity compared with paclitaxel-Cremophor EL. Here, a clinical study
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c04e92d7203913bbc061d4ea791c0b
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