Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Silvia Pirondi"'
1
Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides
Autor: Chiara Marraccini, Gaetano Marverti, Glauco Ponterini, Franca Esposito, Domenico D'Arca, Michela Pela, Maria Rosaria Amoroso, Andrea Martello, Maria Paola Costi, Filippo Genovese, Paul Perco, Remo Guerrini, Alessandra Gualandi, Silvia Pirondi, Laura Taddia
Publikováno v: Journal of proteome research. 13(11)
The preclinical study of the mechanism of action of anticancer small molecules is challenging due to the complexity of cancer biology and the fragmentary nature of available data. With the aim of identifying a protein subset characterizing the cellul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13177a08705826f2eb9cfebe9eaeb43f
https://pubmed.ncbi.nlm.nih.gov/27662068
Zobrazit plný text záznamu
3
Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth
Autor: Michela Pela, Gaetano Marverti, Maria Paola Costi, Filippo Genovese, Chiara Marraccini, Andrea Martello, Glauco Ponterini, Silvia Pirondi, Domenico D'Arca, Puneet Saxena, Stefania Ferrari, Remo Guerrini, Rosaria Luciani, Severo Salvadori, Matteo Santucci
Publikováno v: Journal of medicinal chemistry. 57(4)
Thymidylate synthase (TS) is a target for pemetrexed and the prodrug 5-fluorouracil (5-FU) that inhibit the protein by binding at its active site. Prolonged administration of these drugs causes TS overexpression, leading to drug resistance. The pepti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868ffe1ee098d13eb4647bc803cd996d
https://pubmed.ncbi.nlm.nih.gov/24450514
Zobrazit plný text záznamu
4
Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells
Autor: Silvia Pirondi, Remo Guerrini, Stefania Ferrari, Chiara Marraccini, Giuseppe Cannazza, Gaetano Marverti, Michela Pela, Maria Paola Costi, Giorgia Pavesi, Addolorata Stefania Cazzato, Chiara Frassineti, Glauco Ponterini
Information on the cellular internalization and stability of the ovarian cancer cell growth inhibitor peptide, LSCQLYQR (LR), is vital for lead optimization. Ad-hoc-synthesized LR/fluorescent-probe conjugates were used to monitor the internalization
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a9010f2ef6fe0f76ee026e94570dc
http://pubs.acs.org/jmc
Zobrazit plný text záznamu
7
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines
Autor: Maria Paola Costi, Alberto Venturelli, Cristina Magnoni, Paola Azzoni, Daria Morini, Silvia Pirondi, Stefania Seidenari, Stefania Giudice, Eugenia Veratti, Giorgia Bertazzoni, Luisa Benassi
Melanoma is one of the most common cancers, and its incidence has continued to increase over the past few decades. Chemotherapy resistance and related defects in apoptotic signaling are critical for the high mortality of melanoma. Effective drugs are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa239739eb12d4d69cb855a21221c4e1
https://hdl.handle.net/11380/708554
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje