Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Silvia Pasquini"'
Autor:
Sara Rossi, Vanessa Tatangelo, Maria Dichiara, Stefania Butini, Sandra Gemma, Simone Brogi, Silvia Pasquini, Martina Cappello, Fabrizio Vincenzi, Katia Varani, Ludovica Lopresti, Margherita Malchiodi, Chiara Carrara, Alessandro Gozzetti, Monica Bocchia, Giuseppe Marotta, Laura Patrussi, Gabriele Carullo, Cosima T. Baldari, Giuseppe Campiani
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116537- (2024)
Chronic Lymphocytic Leukemia (CLL) patients have a defective expression of the proapoptotic protein p66Shc and of its transcriptional factor STAT4, which evoke molecular abnormalities, impairing apoptosis and worsening disease prognosis and severity.
Externí odkaz:
https://doaj.org/article/5b5fa73fa7a44b40b6f5ece58f9ee513
Autor:
Mercedes Fernandez, Manuela Nigro, Alessia Travagli, Silvia Pasquini, Fabrizio Vincenzi, Katia Varani, Pier Andrea Borea, Stefania Merighi, Stefania Gessi
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2441 (2023)
The blood–brain barrier (BBB) is a biological barrier that protects the central nervous system (CNS) by ensuring an appropriate microenvironment. Brain microvascular endothelial cells (ECs) control the passage of molecules from blood to brain tissu
Externí odkaz:
https://doaj.org/article/25ad692c1b684bb3a22a929700072748
Autor:
Fabrizio Vincenzi, Silvia Pasquini, Chiara Contri, Martina Cappello, Manuela Nigro, Alessia Travagli, Stefania Merighi, Stefania Gessi, Pier Andrea Borea, Katia Varani
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1387 (2023)
Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues of the body makes them, on the one hand, excellent candidates fo
Externí odkaz:
https://doaj.org/article/37b852a310214c998f146e2d31e82102
Autor:
Stefania Merighi, Alessia Travagli, Manuela Nigro, Silvia Pasquini, Martina Cappello, Chiara Contri, Katia Varani, Fabrizio Vincenzi, Pier Andrea Borea, Stefania Gessi
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 967 (2023)
Alzheimer’s disease (AD) is the most prevalent kind of dementia with roughly 135 million cases expected in the world by 2050. Unfortunately, current medications for the treatment of AD can only relieve symptoms but they do not act as disease-modify
Externí odkaz:
https://doaj.org/article/8f63eea7aa66499fbebfefcebf0b871e
Autor:
Silvia Pasquini, Chiara Contri, Martina Cappello, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Adenosine receptors (ARs) have been identified as promising therapeutic targets for countless pathological conditions, spanning from inflammatory diseases to central nervous system disorders, from cancer to metabolic diseases, from cardiovascular pat
Externí odkaz:
https://doaj.org/article/bf41599c053d48e9b597f7c3c7156374
Autor:
Fabrizio Vincenzi, John Charles Rotondo, Silvia Pasquini, Francesco Di Virgilio, Katia Varani, Mauro Tognon
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Human malignant pleural mesothelioma (MPM) is a rare, but aggressive tumor of the serosal cavities whose 5-year survival rate is 15%. At present, there are no effective therapies for MPM. Although recent findings suggest that A3 adenosine (A3AR) and
Externí odkaz:
https://doaj.org/article/d91d9ef72ea744a38bbe08ea32028683
Autor:
Stefania Merighi, Tino Emanuele Poloni, Lucia Pelloni, Silvia Pasquini, Katia Varani, Fabrizio Vincenzi, Pier Andrea Borea, Stefania Gessi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/64ecd854a7ed425ebff3e49df11e3829
Autor:
Stefania Merighi, Manuela Nigro, Alessia Travagli, Silvia Pasquini, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Stefania Gessi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5056 (2022)
The A2A adenosine receptor, a member of the P1 purinergic receptor family, plays a crucial role in the pathophysiology of different neurodegenerative illnesses, including Alzheimer’s disease (AD). It regulates both neurons and glial cells, thus mod
Externí odkaz:
https://doaj.org/article/83549fa7ed99416ea9ba2369ee195b9a
Autor:
Daniela Catarzi, Flavia Varano, Erica Vigiani, Sara Calenda, Fabrizio Melani, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Natascia Mennini, Giulia Nerli, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 478 (2022)
A new set of amino-3,5-dicyanopyridines was synthesized and biologically evaluated at the adenosine receptors (ARs). This chemical class is particularly versatile, as small structural modifications can influence not only affinity and selectivity, but
Externí odkaz:
https://doaj.org/article/2d4d17b2c4234db89836b4d36ba4b954
Autor:
Stefania Merighi, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Alessia Travagli, Manuela Nigro, Silvia Pasquini, R. Rama Suresh, Sung Won Kim, Nora D. Volkow, Kenneth A. Jacobson, Stefania Gessi
Publikováno v:
Molecules, Vol 27, Iss 9, p 2680 (2022)
The A2A adenosine receptor is a protein belonging to a family of four GPCR adenosine receptors. It is involved in the regulation of several pathophysiological conditions in both the central nervous system and periphery. In the brain, its localization
Externí odkaz:
https://doaj.org/article/4913aae69c9f40a5aaaacc4f9eabe103