Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Silvia Panetti"'
Autor:
Benoit J Van den Eynde, Maryam Ahmad, James McAuliffe, Laurine Noblecourt, Ramiro Andrei Ramirez-Valdez, Vinnycius Pereira-Almeida, Carol Sze Ki Leung, Vincent Stroobant, Amanda Wicki, Silvia Panetti, Emily Steffke, Yushu Hu, Shi Yu William Guo, Julie Lesenfants, Vineethkrishna Chandrasekar, Nathalie Vigneron
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Background Melanoma antigen gene (MAGE)-type antigens are promising targets for cancer immunotherapy as they are expressed in cancer cells but not in normal tissues, except for male germline cells. The mouse P1A antigen shares this MAGE-type expressi
Externí odkaz:
https://doaj.org/article/09e8625b83a644fea1c0f18984102032
Autor:
Livingstone Fultang, Silvia Panetti, Margaret Ng, Paul Collins, Suzanne Graef, Nagy Rizkalla, Sarah Booth, Richard Lenton, Boris Noyvert, Claire Shannon-Lowe, Gary Middleton, Francis Mussai, Carmela De Santo
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 235-246 (2019)
Background: Targeting of MDSCs is a major clinical challenge in the era of immunotherapy. Antibodies which deplete MDSCs in murine models can reactivate T cell responses. In humans such approaches have not developed due to difficulties in identifying
Externí odkaz:
https://doaj.org/article/4484df2a46f841cf91fd257440db08ae
Autor:
Nicholas Jones, Emma E. Vincent, James G. Cronin, Silvia Panetti, Megan Chambers, Sean R. Holm, Sian E. Owens, Nigel J. Francis, David K. Finlay, Catherine A. Thornton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.
Externí odkaz:
https://doaj.org/article/bc506b655aa8451493a382dfb1dd1fe8
Autor:
Nicholas Jones, James G. Cronin, Garry Dolton, Silvia Panetti, Andrea J. Schauenburg, Sarah A. E. Galloway, Andrew K. Sewell, David K. Cole, Catherine A. Thornton, Nigel J. Francis
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Linking immunometabolic adaptation to T-cell function provides insight for the development of new therapeutic approaches in multiple disease settings. T-cell activation and downstream effector functions of CD4+ and CD8+ T-cells are controlled by the
Externí odkaz:
https://doaj.org/article/4e275e64803946f49058ddf4bb81a441
Autor:
Silvia Panetti, Nicola McJannett, Livingstone Fultang, Sarah Booth, Luciana Gneo, Ugo Scarpa, Charles Smith, Ashley Vardon, Lisa Vettore, Celina Whalley, Yi Pan, Csilla Várnai, Hitoshi Endou, Jonathan Barlow, Daniel Tennant, Andrew Beggs, Francis Mussai, Carmela De Santo
Publikováno v:
Blood Advances. 7:1754-1761
Cancer cells take up amino acids from the extracellular space to drive cell proliferation and viability. Similar mechanisms are applied by immune cells, resulting in the competition between conventional T cells, or indeed chimeric antigen receptor (C
Autor:
Victoria Stavrou, Livingstone Fultang, Sarah Booth, Daniele De Simone, Arekdiusz Bartnik, Ugo Scarpa, Luciana Gneo, Silvia Panetti, Sandeep Potluri, Meaad Almowaled, Jonathan Barlow, Andris Jankevics, Gavin Lloyd, Andrew Southam, David A. Priestman, Paul Cheng, Warwick Dunn, Frances Platt, Hitoshi Endou, Charles Craddock, Karen Keeshan, Francis Mussai, Carmela De Santo
Acute myeloid leukaemia (AML) creates an immunosuppressive environment to conventional T cells through Arginase 2 (ARG2)-induced arginine depletion. We identify that AML blasts release the acute phase protein serum amyloid A (SAA), which acts in an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7194899688dbd455a6f962fac909168
https://eprints.gla.ac.uk/277780/1/277780.pdf
https://eprints.gla.ac.uk/277780/1/277780.pdf
MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers
Autor:
Gary Middleton, Nagy Rizkalla, Richard Lenton, Margaret H.L. Ng, Carmela De Santo, Livingstone Fultang, Boris Noyvert, Suzanne Graef, Claire Shannon-Lowe, Sarah Booth, Francis Mussai, Paul Collins, Silvia Panetti
Publikováno v:
EBIOMEDICINE
EBioMedicine
EBioMedicine
Background: Targeting of MDSCs is a major clinical challenge in the era of immunotherapy. Antibodies which deplete MDSCs in murine models can reactivate T cell responses. In humans such approaches have not developed due to difficulties in identifying
Autor:
Silvia Panetti, Nicholas Jones, James G. Cronin, Catherine A. Thornton, David K. Finlay, Megan Chambers, Sian E. Owens, Nigel J. Francis, Emma E. Vincent, Sean R Holm
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Jones, N, Vincent, E E, Cronin, J G, Panetti, S, Chambers, M, Holm, S R, Owens, S E, Francis, N J, Finlay, D K & Thornton, C A 2019, ' Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation ' Nature Communications, vol. 10, no. 1, 2042 . https://doi.org/10.1038/s41467-019-10023-4
Nature Communications
Jones, N, Vincent, E E, Cronin, J G, Panetti, S, Chambers, M, Holm, S R, Owens, S E, Francis, N J, Finlay, D K & Thornton, C A 2019, ' Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation ', Nature Communications, vol. 10, no. 1, 2042 . https://doi.org/10.1038/s41467-019-10023-4
Jones, N, Vincent, E E, Cronin, J G, Panetti, S, Chambers, M, Holm, S R, Owens, S E, Francis, N J, Finlay, D K & Thornton, C A 2019, ' Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation ' Nature Communications, vol. 10, no. 1, 2042 . https://doi.org/10.1038/s41467-019-10023-4
Nature Communications
Jones, N, Vincent, E E, Cronin, J G, Panetti, S, Chambers, M, Holm, S R, Owens, S E, Francis, N J, Finlay, D K & Thornton, C A 2019, ' Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation ', Nature Communications, vol. 10, no. 1, 2042 . https://doi.org/10.1038/s41467-019-10023-4
Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of glycolysis and oxidative phosp
Autor:
Gavin R. Lloyd, Ugo Scarpa, Andrew D. Southam, Barbara Martins da Costa, Orli Yogev, Vanessa Tubb, Carmela De Santo, Silvia Panetti, Livingstone Fultang, Steven P. Lee, Andris Jankevics, Sarah Booth, Louis Chesler, Warwick B. Dunn, Victoria Stavrou, Francis Mussai
Publikováno v:
Blood
Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine microenvironment also impairs chimeric antigen receptor T cells (CAR-T) cell proliferation, limiting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a99a6e5d4ec34ec171f318b81069e40
https://europepmc.org/articles/PMC7565134/
https://europepmc.org/articles/PMC7565134/