Different Oxidative Stress and Inflammation Patterns of Diseased Left Anterior Descending Coronary Artery versus Internal Thoracic Artery

Autor: Andrea Salica, Vittoria Cammisotto, Raffaele Scaffa, Giulio Folino, Ruggero De Paulis, Roberto Carnevale, Umberto Benedetto, Wael Saade, Antonino Marullo, Sebastiano Sciarretta, Gianmarco Sarto, Silvia Palmerio, Valentina Valenti, Mariangela Peruzzi, Fabio Miraldi, Francesco Giosuè Irace, Giacomo Frati

Publikováno v: Antioxidants, Vol 13, Iss 10, p 1180 (2024)

Background. Oxidative stress and inflammation are typically implied in atherosclerosis pathogenesis and progression, especially in coronary artery disease (CAD). Our objective was to investigate the oxidative stress and inflammation burden directly a

Externí odkaz: https://doaj.org/article/a03e47398c9042af9781829f27ff7ce2

Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction

Autor: Albino Carrizzo, Carmine Vecchione, Antonio Damato, Flavio di Nonno, Mariateresa Ambrosio, Franco Pompeo, Enrico Cappello, Luca Capocci, Mariangela Peruzzi, Valentina Valenti, Giuseppe Biondi‐Zoccai, Antonino G. M. Marullo, Silvia Palmerio, Roberto Carnevale, Chiara C. Spinelli, Annibale A. Puca, Speranza Rubattu, Massimo Volpe, Junichi Sadoshima, Giacomo Frati, Sebastiano Sciarretta

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 3 (2017)

Background Endothelial dysfunction contributes significantly to the development of vascular diseases. However, a therapy able to reduce this derangement still needs to be identified. We evaluated the effects of pharmacological inhibition of Rac1, a s

Externí odkaz: https://doaj.org/article/e7849ce37e3848b28185b345ba2dead9

Guideline Application in Real world: multi-Institutional Based survey of Adjuvant and first-Line pancreatic Ductal adenocarcinoma treatment in Italy. Primary analysis of the GARIBALDI survey

Autor: M. Reni, E. Giommoni, F. Bergamo, M. Milella, L. Cavanna, M.C. Di Marco, M. Spada, S. Cordio, G. Aprile, G.G. Cardellino, E. Maiello, I. Bernardini, M. Ghidini, S. Bozzarelli, M. Macchini, G. Orsi, I. De Simone, Er. Rulli, L. Porcu, V. Torri, C. Pinto, Michele Reni, Marina Macchini, Giulia Orsi, Umberto Peretti, Mariamaddalena Valente, Elisa Giommoni, Lorenzo Antonuzzo, Francesco Di Costanzo, Francesca Bergamo, Vittorina Zagonel, Sara Lonardi, Federica Buggin, Michele Milella, Silvia Palmerio, Luigi Cavanna, Camilla Di Nunzio, Maria Cristina Di Marco, Elisa Grassi, Massimiliano Spada, Marco Messina, Stefano Cordio, Francesco Avola, Giuseppe Aprile, Salvatore Pagano, Francesca Simionato, Giovanni Gerardo Cardellino, Federica Majer, Evaristo Maiello, Tiziana Pia Latiano, Cinzia Chiarazzo, Fabrizio Artioli, Giorgia Razzini, Antonella Pasqualini, Michele Ghidini, Elisa Binda, Silvia Lazzarelli, Silvia Bozzarelli, Simona Sala, Gabriele Luppi, Elisa Pettorelli, Andrea Spallanzani, Giovanni Vicario, Flavia Salmaso, Marco Basso, Nicola Silvestris, Sabina Del Curatolo, Fable Zustovich, Francesca Bongiovanni, Ciro Longobardi, Ilenia Sandi, Caterina Fontanella, Silvia Montelatici, Monica Giordano, Giovanna Luchena, Micol Gilardoni, Emiliano Tamburini, Britt Rudnas, Barbara Venturini, Barbara Merelli, Giorgia Negrini, Elio Maria Vici, Alessandra Marabese, Cristina Garetto, Paola Curcio, Saverio Cinieri, Margherita Cinefra, Pasqualinda Ferrara, Maurizio Cantore, Patrizia Morselli, Guglielmo Fumi, Agnese Isidori, Giovanni Ciccarese, Giovanni Luca Paolo Frassineti, Flavia Pagan, Vanja Vaccaro, Chiara Spoto, Marianna Ferrara, Carlo Garufi, Marta Caporale, Enrico Vasile, Francesca Salani, Elisa Barone, Rossana Berardi, Azzurra Onofri, Zelmira Ballatore, Alessandra Lucarelli, Alessandra Barucca, Amedeo Pancotti, Teresa Scipioni, Katia Bencardino, Giovanna Marrapese, Laura Idotta, Fausto Petrelli, Veronica Lonati, Anna Ceribelli, Angelo Giuli, Cristina Zannori, Maria Bassanelli, Andrea Mambrini, Laura Ginocchi, Massimo Orlandi, Luigi Celio, Monica Niger, Lavinia Biamonte, Stefano Tamberi, Alessandra Piancastelli, Giorgio Papiani, Irene Valli, Paolo Allione, Maria Giovanna Boe, Mario Scartozzi, Eleonora Lai, Annagrazia Pireddu, Pina Ziranu, Laura Demurtas, Marco Puzzoni, Stefano Mariani, Andrea Pretta, Nicole Liscia, Clementina Savastano, Valentina Malaspina, Giuseppe Tonini, Teresa Grassani, Barbara Barco, Tagliaferri Pierosandro, Domenico Ciliberto, Antonella Ierardi, Natale Daniele Calandruccio, Vincenzo Minotti, Roberta Matocci, Valter Torri, Luca Porcu, Erica Rulli, Irene De Simone, Luciano Carlucci, Eliana Rulli, Davide Poli, Paola Tonto, Francesca Scellato, Carmine Pinto

Background: Information about the adherence to scientific societies guidelines in the ‘real-world’ therapeutic management of oncological patients are lacking. This multicenter, prospective survey was aimed to improve the knowledge relative to 201

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f827f8705c922ff764aa383826811530
https://hdl.handle.net/11585/919206

The Nucleolar Protein Nucleophosmin Is Physiologically Secreted by Endothelial Cells in Response to Stress Exerting Proangiogenic Activity Both In Vitro and In Vivo

Autor: Roberta Melchionna, Mario Picozza, Marco D'Agostino, Sara Beji, Silvia Palmerio, Alessandra Magenta, Antonia Germani, Anna Di Carlo, Daniele Avitabile, Elena De Falco, Vincenzo Petrozza

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 3672, p 3672 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 7

Nucleophosmin (NPM), a nucleolar multifunctional phosphoprotein, acts as a stress sensor in different cell types. NPM can be actively secreted by inflammatory cells, however its biology on endothelium remains unexplored. In this study, we show for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3616fd8cde30911968e9c0c821e615c5
https://www.mdpi.com/1422-0067/22/7/3672

The Pathophysiological Role of NOX2 in Hypertension and Organ Damage

Autor: Leonardo Schirone, Sebastiano Sciarretta, Maurizio Forte, Valentina Valenti, Cristina Nocella, Silvia Palmerio, Roberto Carnevale, Elena De Falco, Giacomo Frati

Publikováno v: High Blood Pressure & Cardiovascular Prevention. 23:355-364

NADPH oxidases (NOXs) represent one of the major sources of reactive oxygen species in the vascular district. Reactive oxygen species are responsible for vascular damage that leads to several cardiovascular pathological conditions. Among NOX isoforms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3b262e569fac50723e0d0106be48e7
https://doi.org/10.1007/s40292-016-0175-y