Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Silvia Paddock"'
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background The successful introduction of homomorphic encryption (HE) in clinical research holds promise for improving acceptance of data-sharing protocols, increasing sample sizes, and accelerating learning from real-world data (RWD). A wel
Externí odkaz:
https://doaj.org/article/c2ae0ee3357c4706b885f3f15cf47a36
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32304 (2012)
Major depression is nearly twice as prevalent in women compared to men. In bipolar disorder, depressive episodes have been reported to be more common amongst female patients. Furthermore, periods of depression often correlate with periods of hormonal
Externí odkaz:
https://doaj.org/article/f5580eaa527745fd9a682e3c746f7ddf
Autor:
Knut Wehrle, Viola Tozzi, Stefan Braune, Fabian Roßnagel, Heidi Dikow, Silvia Paddock, Arnfin Bergmann, Philip van Hövell
Publikováno v:
JAMIA open. 5(1)
Objective To implement a dynamic data management and control framework that meets the multiple demands of high data quality, rigorous information technology security, and flexibility to continuously incorporate new methodology for a large disease reg
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Medical Informatics and Decision Making
BMC Medical Informatics and Decision Making
Background The successful introduction of homomorphic encryption (HE) in clinical research holds promise for improving acceptance of data-sharing protocols, increasing sample sizes, and accelerating learning from real-world data (RWD). A well-scoped
Autor:
Jacqueline Zummo, Samuel Thomas, Mario Campone, Neon Brooks, Rose Li, David Grainger, Scott Shortenhaus, Silvia Paddock
Publikováno v:
Drugs in Context
Background There is an active debate about the role that endpoints other than overall survival (OS) should play in the drug approval process. Yet the term ‘surrogate endpoint’ implies that OS is the only critical metric for regulatory approval of
Autor:
Jacqueline Zummo, Samuel Thomas, Scott Shortenhaus, Clifford Goodman, David Grainger, Silvia Paddock
Publikováno v:
Future Oncology. 13:2253-2264
Aim: Several recently developed frameworks aim to assess the value of cancer treatments, but the most appropriate metrics remain uncertain. Methods: We use data from the Patient Access to Cancer care Excellence Continuous Innovation Indicators to exa
Publikováno v:
International Journal of Technology Assessment in Health Care. 34:76-77
Introduction:Patient advocates need to process vast amounts of information to accurately and effectively represent heterogeneous patient groups and make meaningful contributions to HTA decisions. Although a wealth of data is available from a variety
Autor:
Anna Håkansson, Olof Sydow, Andrea Carmine Belin, Peter Söderkvist, Marie Westerlund, Thomas Willows, Anna Anvret, Hans Nissbrandt, Silvia Paddock, Caroline Ran, Ahmad Ahmadi, Dagmar Galter, Maria Anvret, Nil Dizdar
Publikováno v:
Neuroscience Letters. 522:30-35
Pesticide exposure has been suggested to increase the risk to develop Parkinson's disease (PD). The arylesterase paraoxonase 1 (PON1) is mainly expressed in the liver and hydrolyzes organophosphates such as pesticides. The polymorphism Leu54Met (rs85
Autor:
Robert Karlsson, Dagmar Galter, Tomas Axelsson, Lisette Graae, Dai Wang, Magnus Lekman, Andrea Carmine Belin, Silvia Paddock, Reyna Favis
Publikováno v:
Biological Psychiatry. 71:922-930
Background Bipolar affective disorder (BPAD) and schizophrenia (SZ) are devastating psychiatric disorders that each affect about 1% of the population worldwide. Identification of new drug targets is an important step toward better treatment of these
Autor:
Husseini K. Manji, Alexander F. Wilson, Francis J. McMahon, Magnus Lekman, Robert H. Lipsky, Dennis S. Charney, Silvia Paddock, Gonzalo Laje, Alexa J.M. Sorant, Stephen R. Wisniewski, A. John Rush
Publikováno v:
Biological Psychiatry. 63:1103-1110
Background In a recent study of several antidepressant drugs in hospitalized, non-Hispanic White patients, Binder et al. reported association of markers located within the FKBP5 gene with treatment response after 2 and 5 weeks. Individuals homozygous