Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Silvia Noiman"'
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97696 (2014)
This study describes the development of aptamers as a therapy against influenza virus infection. Aptamers are oligonucleotides (like ssDNA or RNA) that are capable of binding to a variety of molecular targets with high affinity and specificity. We ha
Externí odkaz:
https://doaj.org/article/2b4c40e70d47467ba61c990a90c32a82
Autor:
Paul E. Gold, Frank Lezoualc'h, Yael Marantz, Sharon Shacham, Silvia Noiman, Sylvain J. Robert, Joseph Rutkowski, Aline Dumuis, Joël Bockaert, Michael E. Ragozzino, Eric G. Mohler, Monique Gastineau
Publikováno v:
Neuropharmacology. 53:563-573
Recent evidence suggests that 5-hydroxytryptamine (5-HT)(4) receptor activity enhances cognition and provides neuroprotection. Here we report the effects of VRX-03011, a novel partial 5-HT(4) agonist, that is both potent (K(i) approximately 30 nM) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47071a0425a1e45627c3ec5ebe129c17
https://doi.org/10.1016/j.neuropharm.2007.06.016
https://doi.org/10.1016/j.neuropharm.2007.06.016
Autor:
Yael Marantz, Alexander Heifetz, Dora Warshaviak, Silvia Noiman, Boaz Inbal, Maya Topf, Merav Fichman, Oren M. Becker, Zvi Naor, Noa Avisar, Sharon Shacham, Ori Kalid, Shay Bar-Haim
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 57:51-86
G-protein coupled receptors (GPCRs) are a major group of drug targets for which only one x-ray structure is known (the nondrugable rhodopsin), limiting the application of structure-based drug discovery to GPCRs. In this paper we present the details o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f73d8d55d83853d9da9bf9ea2b2dc1
https://doi.org/10.1002/prot.20195
https://doi.org/10.1002/prot.20195
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e97696 (2014)
PLoS ONE, Vol 9, Iss 5, p e97696 (2014)
This study describes the development of aptamers as a therapy against influenza virus infection. Aptamers are oligonucleotides (like ssDNA or RNA) that are capable of binding to a variety of molecular targets with high affinity and specificity. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa274b5d459a849a3d21591b7aacd154
http://europepmc.org/articles/PMC4028238
http://europepmc.org/articles/PMC4028238
Autor:
Oren Becker, Sharon Shacham, Zvi Naor, Silvia Noiman, Maya Topf, Fabian Glaser, Yael Marantz, Shay Bar-Haim, Noa Avisar
Publikováno v:
Medicinal Research Reviews. 21:472-483
G-protein-coupled receptors (GPCRs) are a large and functionally diverse protein superfamily, which form a seven transmembrane (TM) helices bundle with alternating extra-cellular and intracellular loops. GPCRs are considered to be one of the most imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4edc3709346c850e82f75abbeaa49f
https://doi.org/10.1002/med.1019
https://doi.org/10.1002/med.1019
Publikováno v:
Virology. 202:401-407
The X protein (pX) of hepatitis B virus (HBV) is a general transcription regulator and directly associated with the transcription machinery. pX cannot bind DNA directly but interacts with cellular factors that bind the regulatory elements. There is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a8d90b0f1f8e364a433c0f864ba866
https://doi.org/10.1006/viro.1994.1356
https://doi.org/10.1006/viro.1994.1356
Autor:
Oren Becker, Sharon Shacham, Maya Topf, Shay Bar-Haim, Silvia Noiman, Noa Avisar, Zvi Naor, Yael Marantz, Fabian Glaser
Publikováno v:
ChemInform. 32
G-protein-coupled receptors (GPCRs) are a large and functionally diverse protein superfamily, which form a seven transmembrane (TM) helices bundle with alternating extracellular and intracellular loops. GPCRs are considered to be one of the most impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab1c20c3c40bad4455eb445cb0d0b518
https://doi.org/10.1002/chin.200144294
https://doi.org/10.1002/chin.200144294
Autor:
Yael Marantz, Lobera Mercedes, Sharon Shacham, Bill Ph. D. Milgram, Michael Ragazzino, Eric G. Mohler, Joseph A. Araujo, Silvia Noiman
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06bf72ed138b9dccd57f1301e08ed9b
https://doi.org/10.1016/j.jalz.2006.05.225
https://doi.org/10.1016/j.jalz.2006.05.225
Autor:
Oren M. Becker, Merav Fichman, Alexander Heifetz, Chen Dongli, Michael Kauffman, Dhanoa Dale S, Yael Marantz, Srinivasa Rao Cheruku, Sharon Shacham, Raphael Nudelman, Silvia Noiman, Anurag Sharadendu, Pradyumna Mohanty
Publikováno v:
Journal of medicinal chemistry. 49(11)
We report the discovery of a novel, potent, and selective amidosulfonamide nonazapirone 5-HT1A agonist for the treatment of anxiety and depression, which is now in Phase III clinical trials for generalized anxiety disorder (GAD). The discovery of 20m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31e77b183143d1a3fe29804546d7fdf
https://pubmed.ncbi.nlm.nih.gov/16722631
https://pubmed.ncbi.nlm.nih.gov/16722631
Autor:
Merav Fichman, Oren M. Becker, Sharon Shacham, Dora Warshaviak, Shay Bar-Haim, Silvia Noiman, Boaz Inbal, Ori Kalid, Alexander Heifetz, Yael Marantz
The application of structure-based in silico methods to drug discovery is still considered a major challenge, especially when the x-ray structure of the target protein is unknown. Such is the case with human G protein-coupled receptors (GPCRs), one o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507cf343de0fe9320a4ed5905da87dd
https://europepmc.org/articles/PMC509175/
https://europepmc.org/articles/PMC509175/
