The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

Autor: Silvia N Kariuki, Alexander W Macharia, Johnstone Makale, Wilfred Nyamu, Stephen L Hoffman, Melissa C Kapulu, Philip Bejon, Julian C Rayner, Thomas N Williams, On behalf of for the CHMI-SIKA Study Team

Publikováno v: eLife, Vol 12 (2023)

Background: The long co-evolution of Homo sapiens and Plasmodium falciparum has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the Dantu blood group antigen,

Externí odkaz: https://doaj.org/article/d7bea6c1ed454a08936dbbdec5422d73

Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.

Autor: Silvia N Kariuki, Joseph C Maranville, Shaneen S Baxter, Choongwon Jeong, Shigeki Nakagome, Cara L Hrusch, David B Witonsky, Anne I Sperling, Anna Di Rienzo

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159779 (2016)

The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to characterize the genetic basis

Externí odkaz: https://doaj.org/article/a3bda036e36d4024a79c6954c3b85d68

Author response: BIRC6 modifies risk of invasive bacterial infection in Kenyan children

Autor: James J Gilchrist, Silvia N Kariuki, James A Watson, Gavin Band, Sophie Uyoga, Carolyne M Ndila, Neema Mturi, Salim Mwarumba, Shebe Mohammed, Moses Mosobo, Kaur Alasoo, Kirk A Rockett, Alexander J Mentzer, Dominic P Kwiatkowski, Adrian VS Hill, Kathryn Maitland, J Anthony G Scott, Thomas N Williams

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bd7f878df340d147e4b3bbbe3a4000d
https://doi.org/10.7554/elife.77461.sa2

Human genetics and malaria resistance

Autor: Silvia N. Kariuki, Thomas N. Williams

Publikováno v: Human Genetics

Malaria has been the pre-eminent cause of early mortality in many parts of the world throughout much of the last five thousand years and, as a result, it is the strongest force for selective pressure on the human genome yet described. Around one thir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffe786c40ee757798268bd870924d50
https://doi.org/10.1007/s00439-020-02142-6

Red blood cell tension protects against severe malaria in the Dantu blood group

Autor: Dominic P. Kwiatkowski, Yen-Chun Lin, Thomas N. Williams, Johnstone Makale, Alex Macharia, Julian C. Rayner, Benjamin J. Ravenhill, Wilfred Nyamu, Manuela Carrasquilla, Michael P. Weekes, Pietro Cicuta, Kirk A. Rockett, Alejandro Marin-Menendez, Jurij Kotar, Viola Introini, Metrine Tendwa, J. Alexandra Rowe, Silvia N. Kariuki

Publikováno v: Kariuki, S, Marin-Menendez, A, Introini, V, Ravenhill, B J, Lin, Y C, Macharia, A, Makale, J, Tendwa, M, Nyamu, W, Kotar, J, Carrasquilla, M, Rowe, A J, Rockett, K A, Kwiatkowski, D P, Weekes, M P, Cicuta, P, Williams, T N & Rayner, J C 2020, ' Red blood cell tension protects against severe malaria in the Dantu blood group ', Nature, vol. 585, no. 7826, pp. 579-583 . https://doi.org/10.1038/s41586-020-2726-6
Nature

Malaria has had a major effect on the human genome, with many protective polymorphisms-such as the sickle-cell trait-having been selected to high frequencies in malaria-endemic regions1,2. The blood group variant Dantu provides 74% protection against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19654963f2d00c404ce3c5e3ff314214