Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Silvia N Kariuki"'
Autor:
Silvia N Kariuki, Alexander W Macharia, Johnstone Makale, Wilfred Nyamu, Stephen L Hoffman, Melissa C Kapulu, Philip Bejon, Julian C Rayner, Thomas N Williams, On behalf of for the CHMI-SIKA Study Team
Publikováno v:
eLife, Vol 12 (2023)
Background: The long co-evolution of Homo sapiens and Plasmodium falciparum has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the Dantu blood group antigen,
Externí odkaz:
https://doaj.org/article/d7bea6c1ed454a08936dbbdec5422d73
Autor:
Viola Introini, Alejandro Marin-Menendez, Guilherme Nettesheim, Yen-Chun Lin, Silvia N. Kariuki, Adrian L. Smith, Letitia Jean, John N. Brewin, David C. Rees, Pietro Cicuta, Julian C. Rayner, Bridget S. Penman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Malaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with malaria protection, beta thalassaemia (a haemoglobinopathy) was the earliest to be
Externí odkaz:
https://doaj.org/article/e6afa95052a148bb94000f442cc19fc0
Autor:
James J Gilchrist, Silvia N Kariuki, James A Watson, Gavin Band, Sophie Uyoga, Carolyne M Ndila, Neema Mturi, Salim Mwarumba, Shebe Mohammed, Moses Mosobo, Kaur Alasoo, Kirk A Rockett, Alexander J Mentzer, Dominic P Kwiatkowski, Adrian VS Hill, Kathryn Maitland, J Anthony G Scott, Thomas N Williams
Publikováno v:
eLife, Vol 11 (2022)
Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite being caused by diverse pathogens, children with sepsis are clinically indistinguishable from one another. In spite of this, most genetic susceptibili
Externí odkaz:
https://doaj.org/article/5b632ded377f43c8bc16485a42752ec1
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 5, Pp 1345-1355 (2016)
The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), plays an important immunomodulatory role, regulating transcription of genes in the innate and adaptive immune system. The present study examines patterns of transcriptome-wide response t
Externí odkaz:
https://doaj.org/article/9c09026c70ea41799f46da46a8c28350
Autor:
James J Gilchrist, Silvia N Kariuki, James A Watson, Gavin Band, Sophie Uyoga, Carolyne M Ndila, Neema Mturi, Salim Mwarumba, Shebe Mohammed, Moses Mosobo, Kaur Alasoo, Kirk A Rockett, Alexander J Mentzer, Dominic P Kwiatkowski, Adrian VS Hill, Kathryn Maitland, J Anthony G Scott, Thomas N Williams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bd7f878df340d147e4b3bbbe3a4000d
https://doi.org/10.7554/elife.77461.sa2
https://doi.org/10.7554/elife.77461.sa2
Autor:
Silvia N Kariuki, Joseph C Maranville, Shaneen S Baxter, Choongwon Jeong, Shigeki Nakagome, Cara L Hrusch, David B Witonsky, Anne I Sperling, Anna Di Rienzo
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159779 (2016)
The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is an important modulator of the immune system, inhibiting cellular proliferation and regulating transcription of immune response genes. In order to characterize the genetic basis
Externí odkaz:
https://doaj.org/article/a3bda036e36d4024a79c6954c3b85d68
Autor:
Silvia N. Kariuki, Thomas N. Williams
Publikováno v:
Human Genetics
Malaria has been the pre-eminent cause of early mortality in many parts of the world throughout much of the last five thousand years and, as a result, it is the strongest force for selective pressure on the human genome yet described. Around one thir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffe786c40ee757798268bd870924d50
https://doi.org/10.1007/s00439-020-02142-6
https://doi.org/10.1007/s00439-020-02142-6
Autor:
Dorothy Mangale, Silvia N. Kariuki, Beverly S. Chrabot, Marissa Kumabe, Jennifer A. Kelly, John B. Harley, Judith A. James, Kathy L. Sivils, Timothy B. Niewold
Publikováno v:
Clinical and Developmental Immunology, Vol 2013 (2013)
Systemic lupus erythematosus (SLE) patients frequently have high circulating tumor necrosis factor alpha (TNF-α) levels. We explored circulating TNF-α levels in SLE families to determine whether high levels of TNF-α were clustered in a heritable p
Externí odkaz:
https://doaj.org/article/158b3e194e424a39bd74df07e5bd322c
Autor:
Dominic P. Kwiatkowski, Yen-Chun Lin, Thomas N. Williams, Johnstone Makale, Alex Macharia, Julian C. Rayner, Benjamin J. Ravenhill, Wilfred Nyamu, Manuela Carrasquilla, Michael P. Weekes, Pietro Cicuta, Kirk A. Rockett, Alejandro Marin-Menendez, Jurij Kotar, Viola Introini, Metrine Tendwa, J. Alexandra Rowe, Silvia N. Kariuki
Publikováno v:
Kariuki, S, Marin-Menendez, A, Introini, V, Ravenhill, B J, Lin, Y C, Macharia, A, Makale, J, Tendwa, M, Nyamu, W, Kotar, J, Carrasquilla, M, Rowe, A J, Rockett, K A, Kwiatkowski, D P, Weekes, M P, Cicuta, P, Williams, T N & Rayner, J C 2020, ' Red blood cell tension protects against severe malaria in the Dantu blood group ', Nature, vol. 585, no. 7826, pp. 579-583 . https://doi.org/10.1038/s41586-020-2726-6
Nature
Nature
Malaria has had a major effect on the human genome, with many protective polymorphisms-such as the sickle-cell trait-having been selected to high frequencies in malaria-endemic regions1,2. The blood group variant Dantu provides 74% protection against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19654963f2d00c404ce3c5e3ff314214
Autor:
Yelena Koldobskaya, Kichul Ko, Akaash A. Kumar, Sandra Agik, Jasmine Arrington, Silvia N. Kariuki, Beverly S. Franek, Marissa Kumabe, Tammy O. Utset, Meenakshi Jolly, Andrew D. Skol, Timothy B. Niewold
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disorder characterized by differences in autoantibody profiles, serum cytokines, and clinical manifestations. We have previously conducted a case-case genome-wide association stu
Externí odkaz:
https://doaj.org/article/8de1dfd2d8db4ccdbaba4a420e94f627