Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database

Autor: Masaaki Miyazawa, Takao Ashikaga, Sebastian Hoffmann, Magalie Cluzel, Dirk Petersohn, Martina Klaric, Nichola Gellatly, Nathalie Alépée, Nicole Kleinstreuer, Petra S. Kern, Erwin van Vliet, A.M. Api, Elodie Clouet, Jochen Kühnl, J F Lalko, R. Parakhia, Bertrand Desprez, Silvia Martinozzi-Teissier, Karsten Rüdiger Mewes, Qingda Zang, David Allen, Carsten Goebel

Publikováno v: Critical Reviews in Toxicology. 48:344-358

Cosmetics Europe, the European Trade Association for the cosmetics and personal care industry, is conducting a multi-phase program to develop regulatory accepted, animal-free testing strategies enabling the cosmetics industry to conduct safety assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf62b5314b3830cd154889daf1fd207
https://doi.org/10.1080/10408444.2018.1429385

State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop

Autor: Del Bufalo A, Nichola Gellatly, Magalie Cluzel, Delrue N, Sebastian Hoffmann, Giese C, Takao Ashikaga, van Vliet E, Emanuela Corsini, Carsten Goebel, Silvia Martinozzi-Teissier, Jochen Kühnl, Desprez B, Marc Vocanson, Dirk Petersohn, Martina Klaric, Nathalie Alépée, Brunhilde Blömeke, Dean J. Naisbitt, Laura Gribaldo, Marc Pallardy, Maillere B

Publikováno v: ALTEX. 35(2)

Significant progress has been made in the development and validation of non-animal test methods for skin sensitization assessment. At present, three of the four key events of the Adverse Outcome Pathway (AOP) are assessable by OECD-accepted in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2c48a95c835f4cac0a58376bf640b7
https://pubmed.ncbi.nlm.nih.gov/28968481

Identifying and characterizing chemical skin sensitizers without animal testing: Colipa’s research and method development program

Autor: Hitoshi Sakaguchi, Kerstin Reisinger, Andreas Schepky, Sandrine Bessou-Touya, Pierre Aeby, Frank Gerberick, Silvia Martinozzi-Teissier, Takao Ashikaga, Jean Marc Ovigne, Monique Marrec-Fairley, Gavin Maxwell, Petra Winkler, Magalie Tailhardat, Petra S. Kern

Publikováno v: Toxicology in Vitro. 24:1465-1473

The sensitizing potential of chemicals is usually identified and characterized using one of the available animal test methods, such as the mouse local lymph node assay. Due to the increasing public and political concerns regarding the use of animals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2449ffac31a8fe65cfb67726be1e4cb
https://doi.org/10.1016/j.tiv.2010.07.005

Contact sensitizers modulate the arachidonic acid metabolism of PMA-differentiated U-937 monocytic cells activated by LPS

Autor: Christophe Dardenne, Denis Verda, Aurélia Del Bufalo, José Bernad, Françoise Rousset, Silvia Martinozzi-Teissier, Bernard Pipy, Jean Roch Meunier

Publikováno v: Toxicology and applied pharmacology. 256(1)

For the effective induction of a hapten-specific T cell immune response toward contact sensitizers, in addition to covalent-modification of skin proteins, the redox and inflammatory statuses of activated dendritic cells are crucial. The aim of this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444f6ac49c9ee2e24cac76e6d5f629cb
https://pubmed.ncbi.nlm.nih.gov/21807015

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

Autor: Dirk Petersohn, Martina Klaric, Andreas Natsch, Valentina Galbiati, Takao Ashikaga, Nathalie Alépée, Andreas Schepky, Gavin Maxwell, Marion Millet, Marie Templier, Donald Keller, Nathalie Lambrechts, Magalie Tailhardat, Nicola Gellatly, Erwin van Vliet, Ian Pike, Jalila Hibatallah, Petra S. Kern, Malin Lindstedt, Sebastian Hoffmann, Hervé Groux, Kerstin Reisinger, Cliff Elcombe, João Barroso, Hitoshi Sakaguchi, Jochen Kuehnl, Silvia Martinozzi-Teissier, Susan Gibbs, Susanne N. Kolle

Publikováno v: Toxicology in vitro, 29(1), 259-270. Elsevier
Toxicology in Vitro, 29(1), 259-270. Elsevier Limited
Europe PubMed Central
Reisinger, K, Hoffmann, S, Alepee, N, Ashikaga, T, Barroso, J, Elcombe, C, Gellatly, N, Galbiati, V, Gibbs, S, Groux, H, Hibatallah, J, Keller, D, Kern, P, Klaric, M, Kolle, S, Kuehnl, J, Lambrechts, N, Lindstedt, M, Millet, M, Martinozzi-Teissier, S, Natsch, A, Petersohn, D, Pike, I, Sakaguchi, H, Schepky, A, Tailhardat, M, Templier, M, van Vliet, E & Maxwell, G 2015, ' Systematic evaluation of non-animal test methods for skin sensitisation safety assessment ', Toxicology in Vitro, vol. 29, no. 1, pp. 259-270 . https://doi.org/10.1016/j.tiv.2014.10.018
Reisinger, K, Hoffmann, S, Alépée, N, Ashikaga, T, Barroso, J, Elcombe, C, Gellatly, N, Galbiati, V, Gibbs, S, Groux, H, Hibatallah, J, Keller, D, Kern, P, Klaric, M, Kolle, S, Kuehnl, J, Lambrechts, N, Lindstedt, M, Millet, M, Martinozzi-Teissier, S, Natsch, A, Petersohn, D, Pike, I, Sakaguchi, H, Schepky, A, Tailhardat, M, Templier, M, van Vliet, E & Maxwell, G 2015, ' Systematic evaluation of non-animal test methods for skin sensitisation safety assessment ', Toxicology in Vitro, vol. 29, no. 1, pp. 259-270 . https://doi.org/10.1016/j.tiv.2014.10.018

The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868570b89de5b4cc8882a03220fcd4c0