Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Silvia Marsala"'
Autor:
Yoshiomi Kobayashi, Michiko Shigyo, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato, Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas, Jana Juhasova, Hana Studenovska, Vladimir Proks, Shawn P. Driscoll, Thomas D. Glenn, Samuel L. Pfaff, Joseph D. Ciacci, Martin Marsala
Publikováno v:
Cell Transplantation, Vol 32 (2023)
One of the challenges in clinical translation of cell-replacement therapies is the definition of optimal cell generation and storage/recovery protocols which would permit a rapid preparation of cell-treatment products for patient administration. Besi
Externí odkaz:
https://doaj.org/article/53f0f5b81b344c76bd490c0f787e3315
Autor:
Michiko Shigyo, Yoshiomi Kobayashi, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato Jr, Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas, Jana Juhasova, Hana Studenovska, Vladimir Proks, Joseph D. Ciacci, Martin Marsala
Publikováno v:
Cell Transplantation, Vol 32 (2023)
The critical requirements in developing clinical-grade human-induced pluripotent stem cells–derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable in vivo post-grafting differentiation, and acceptable s
Externí odkaz:
https://doaj.org/article/4bcfd17772b643418267888175aa8508
Autor:
Martin Marsala, Kota Kamizato, Takahiro Tadokoro, Michael Navarro, Stefan Juhas, Jana Juhasova, Silvia Marsala, Hana Studenovska, Vladimir Proks, Tom Hazel, Karl Johe, Manabu Kakinohana, Shawn Driscoll, Thomas Glenn, Samuel Pfaff, Joseph Ciacci
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 2, Pp 177-188 (2020)
Abstract Neural precursor cells (NSCs) hold great potential to treat a variety of neurodegenerative diseases and injuries to the spinal cord. However, current delivery techniques require an invasive approach in which an injection needle is advanced i
Externí odkaz:
https://doaj.org/article/ff2e2f3f002c42e4b2b8ed1b25389c95
Autor:
Dasa Bohaciakova, Marian Hruska-Plochan, Rachel Tsunemoto, Wesley D. Gifford, Shawn P. Driscoll, Thomas D. Glenn, Stephanie Wu, Silvia Marsala, Michael Navarro, Takahiro Tadokoro, Stefan Juhas, Jana Juhasova, Oleksandr Platoshyn, David Piper, Vickie Sheckler, Dara Ditsworth, Samuel L. Pfaff, Martin Marsala
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Background A well-characterized method has not yet been established to reproducibly, efficiently, and safely isolate large numbers of clinical-grade multipotent human neural stem cells (hNSCs) from embryonic stem cells (hESCs). Consequently,
Externí odkaz:
https://doaj.org/article/f87a5d79962b40ba83ca9d1341131d90
Autor:
Atsushi Miyanohara, Kota Kamizato, Stefan Juhas, Jana Juhasova, Michael Navarro, Silvia Marsala, Nada Lukacova, Marian Hruska-Plochan, Erik Curtis, Brandon Gabel, Joseph Ciacci, Eric T Ahrens, Brian K Kaspar, Don Cleveland, Martin Marsala
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult a
Externí odkaz:
https://doaj.org/article/2656793c9c4b4a1bb3e8f01a16e8dd29
Autor:
Michael P Hefferan, Jan Galik, Osamu Kakinohana, Gabriela Sekerkova, Camila Santucci, Silvia Marsala, Roman Navarro, Marian Hruska-Plochan, Karl Johe, Eva Feldman, Don W Cleveland, Martin Marsala
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42614 (2012)
Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase (SOD1) causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in motor neurons drives disease onset and early disease progression. Previous experimenta
Externí odkaz:
https://doaj.org/article/e8b98b01a9394c95af3b3e319e6e0d06
Autor:
Osamu Kakinohana, Michael P Hefferan, Atsushi Miyanohara, Tetsuya Nejime, Silvia Marsala, Stefan Juhas, Jana Juhasova, Jan Motlik, Karolina Kucharova, Jan Strnadel, Oleksandr Platoshyn, Peter Lazar, Jan Galik, Laurent Vinay, Martin Marsala
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30561 (2012)
Loss of GABA-mediated pre-synaptic inhibition after spinal injury plays a key role in the progressive increase in spinal reflexes and the appearance of spasticity. Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effec
Externí odkaz:
https://doaj.org/article/6169f72d417149448f6d6d804c355c24
Autor:
Shauna H Yuan, Jody Martin, Jeanne Elia, Jessica Flippin, Rosanto I Paramban, Mike P Hefferan, Jason G Vidal, Yangling Mu, Rhiannon L Killian, Mason A Israel, Nil Emre, Silvia Marsala, Martin Marsala, Fred H Gage, Lawrence S B Goldstein, Christian T Carson
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17540 (2011)
Neural induction of human pluripotent stem cells often yields heterogeneous cell populations that can hamper quantitative and comparative analyses. There is a need for improved differentiation and enrichment procedures that generate highly pure popul
Externí odkaz:
https://doaj.org/article/b56b0088093f4d5f81634553f591aa8c
Autor:
Dusan Usvald, Peter Vodicka, Jana Hlucilova, Radek Prochazka, Jan Motlik, Karolina Kuchorova, Karl Johe, Silvia Marsala, Miriam Scadeng, Osamu Kakinohana, Roman Navarro, Marian Santa, Michael P. Hefferan, Tony L. Yaksh, Martin Marsala
Publikováno v:
Cell Transplantation, Vol 19 (2010)
In recent studies using a rat aortic balloon occlusion model, we have demonstrated that spinal grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to progressive amelioration of spasticity and rigidity and correspondin
Externí odkaz:
https://doaj.org/article/9502efaf0c1341d68db7fac66301b1ba
Autor:
Takahiro Tadokoro, Mariana Bravo-Hernandez, Kirill Agashkov, Yoshiomi Kobayashi, Oleksandr Platoshyn, Michael Navarro, Silvia Marsala, Atsushi Miyanohara, Tetsuya Yoshizumi, Michiko Shigyo, Volodymyr Krotov, Stefan Juhas, Jana Juhasova, Duong Nguyen, Helena Kupcova Skalnikova, Jan Motlik, Hana Studenovska, Vladimir Proks, Rajiv Reddy, Shawn P. Driscoll, Thomas D. Glenn, Taratorn Kemthong, Suchinda Malaivijitnond, Zoltan Tomori, Ivo Vanicky, Manabu Kakinohana, Samuel L. Pfaff, Joseph Ciacci, Pavel Belan, Martin Marsala
Publikováno v:
Molecular Therapy. 30:2722-2745
Second-order spinal cord excitatory neurons play a key role in spinal processing and transmission of pain signals to the brain. Exogenously induced change in developmentally imprinted excitatory neurotransmitter phenotypes of these neurons to inhibit