Rational Engineering of a Flavoprotein Oxidase for Improved Direct Oxidation of Alcohols to Carboxylic Acids

Autor: Mathias Pickl, Christoph K. Winkler, Silvia M. Glueck, Marco W. Fraaije, Kurt Faber

Publikováno v: Molecules, Vol 22, Iss 12, p 2205 (2017)

The oxidation of alcohols to the corresponding carbonyl or carboxyl compounds represents a convenient strategy for the selective introduction of electrophilic carbon centres into carbohydrate-based starting materials. The O2-dependent oxidation of pr

Externí odkaz: https://doaj.org/article/a8ce64438a014982852fc793f5b01550

Enzymatic Conversion of CO2: From Natural to Artificial Utilization

Autor: Sarah Bierbaumer, Maren Nattermann, Luca Schulz, Reinhard Zschoche, Tobias J. Erb, Christoph K. Winkler, Matthias Tinzl, Silvia M. Glueck

Publikováno v: Chemical reviews

Enzymatic carbon dioxide fixation is one of the most important metabolic reactions as it allows the capture of inorganic carbon from the atmosphere and its conversion into organic biomass. However, due to the often unfavorable thermodynamics and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d6895699a39c4b8e88374f4b40f537
https://doi.org/10.1021/acs.chemrev.2c00581

Metal Ion Promiscuity and Structure of 2,3‐Dihydroxybenzoic Acid Decarboxylase of Aspergillus oryzae

Autor: Stefan E. Payer, Walter Goessler, Fahmi Himo, Silvia M. Glueck, Kurt Faber, Gerhard Hofer, Xiang Sheng, Katharina Plasch, Simone Braeuer, Walter Keller

Publikováno v: Chembiochem
ChemBioChem 22(4), 652-656 (2020). doi:10.1002/cbic.202000600

ChemBioChem 22(4), 652 - 656 (2020). doi:10.1002/cbic.202000600
Broad substrate tolerance and excellent regioselectivity, as well as independence from sensitive cofactors have established benzoic acid decarboxylases from microbial sources as eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c73cef9084a283b480d9e92d5781d7
https://doi.org/10.1002/cbic.202000600

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol

Autor: Katharina Plasch, Silvia M. Glueck, Kurt Faber, Sam Hay, Walter Keller, Gerhard Hofer, Alexander Dennig, Derren J. Heyes

Publikováno v: Plasch, K, Hofer, G, Keller, W, Hay, S, Heyes, D, Dennig, A, Glueck, S M & Faber, K 2018, ' Pressurized CO 2 as Carboxylating Agent for the Biocatalytic ortho-Carboxylation of Resorcinol ', Green Chemistry . https://doi.org/10.1039/C8GC00008E

The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on large scale. As proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a6cc1af7d60cdf5eb6eec37414a185
https://doi.org/10.1039/c8gc00008e

Development and Scaling-Up of the Fragrance Compound 4-Ethylguaiacol Synthesis via a Two-Step Chemo-Enzymatic Reaction Sequence

Autor: Kurt Faber, Lorenzo Pesci, Andreas Liese, Silvia M. Glueck, Maik Baydar, Selin Kara

Publikováno v: Organic Process Research & Development. 21:85-93

The transformation of (abundant) oxygenated biomass-derived building blocks via chemo-enzymatic methods is a valuable concept for accessing useful compounds, as it combines the high selectivity of enzymes and the versatility of chemical catalysts. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::775d664bce23a988b0df050cd9a5ff4d
https://doi.org/10.1021/acs.oprd.6b00362