Cyclosporine A Treatment Inhibits Abcc6-Dependent Cardiac Necrosis and Calcification following Coxsackievirus B3 Infection in Mice.

Autor: Jennifer Marton, Danica Albert, Sean A Wiltshire, Robin Park, Arthur Bergen, Salman Qureshi, Danielle Malo, Yan Burelle, Silvia M Vidal

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138222 (2015)

Coxsackievirus type B3 (CVB3) is a cardiotropic enterovirus. Infection causes cardiomyocyte necrosis and myocardial inflammation. The damaged tissue that results is replaced with fibrotic or calcified tissue, which can lead to permanently altered car

Externí odkaz: https://doaj.org/article/794c48f3d4514857872105c4898b5305

Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.

Autor: Grégory Caignard, Gabriel A Leiva-Torres, Michael Leney-Greene, Benoit Charbonneau, Anne Dumaine, Nassima Fodil-Cornu, Michal Pyzik, Pablo Cingolani, Jeremy Schwartzentruber, Jeremy Dupaul-Chicoine, Huaijian Guo, Maya Saleh, André Veillette, Marc Lathrop, Mathieu Blanchette, Jacek Majewski, Angela Pearson, Silvia M Vidal

Publikováno v: PLoS Pathogens, Vol 9, Iss 9, p e1003637 (2013)

Herpes simplex encephalitis (HSE) is a lethal neurological disease resulting from infection with Herpes Simplex Virus 1 (HSV-1). Loss-of-function mutations in the UNC93B1, TLR3, TRIF, TRAF3, and TBK1 genes have been associated with a human genetic pr

Externí odkaz: https://doaj.org/article/cde333edced84b53aa1844cc39d31dbf

Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells.

Autor: Julien Pothlichet, Isabelle Meunier, Beckley K Davis, Jenny P-Y Ting, Emil Skamene, Veronika von Messling, Silvia M Vidal

Publikováno v: PLoS Pathogens, Vol 9, Iss 4, p e1003256 (2013)

Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1β response is mediated by innate receptors in macrophages and lung epithelial cells. NLRP3 is crucial in macrophages; however, which sensors e

Externí odkaz: https://doaj.org/article/abc75a8c3f6e416caf8b8c0b6b4f5115

NK cell receptor/H2-Dk-dependent host resistance to viral infection is quantitatively modulated by H2q inhibitory signals.

Autor: Nassima Fodil-Cornu, J Concepción Loredo-Osti, Silvia M Vidal

Publikováno v: PLoS Genetics, Vol 7, Iss 4, p e1001368 (2011)

The cytomegalovirus resistance locus Cmv3 has been linked to an epistatic interaction between two loci: a Natural Killer (NK) cell receptor gene and the major histocompatibility complex class I (MHC-I) locus. To demonstrate the interaction between Cm

Externí odkaz: https://doaj.org/article/8502000a62b049718182d49f6c17e418

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

Autor: Zhang Xu, Jung-Hyun Choi, David L. Dai, Jun Luo, Reese Jalal Ladak, Qian Li, Yimeng Wang, Christine Zhang, Shane Wiebe, Alex C. H. Liu, Xiaozhuo Ran, Jiaqi Yang, Parisa Naeli, Aitor Garzia, Lele Zhou, Niaz Mahmood, Qiyun Deng, Mohamed Elaish, Rongtuan Lin, Lara K. Mahal, Tom C. Hobman, Jerry Pelletier, Tommy Alain, Silvia M. Vidal, Thomas Duchaine, Mohammad T. Mazhab-Jafari, Xiaojuan Mao, Seyed Mehdi Jafarnejad, Nahum Sonenberg

Publikováno v: Xu, Z, Choi, J-H, Dai, D L, Luo, J, Ladak, R J, Li, Q, Wang, Y, Zhang, C, Wiebe, S, Liu, A C H, Ran, X, Yang, J, Naeli, P, Garzia, A, Zhou, L, Mahmood, N, Deng, Q, Elaish, M, Lin, R, Mahal, L K, Hobman, T C, Pelletier, J, Alain, T, Vidal, S M, Duchaine, T, Mazhab-Jafari, M T, Mao, X, Jafarnejad, S M & Sonenberg, N 2022, ' SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 32, e2204539119 . https://doi.org/10.1073/pnas.2204539119

Viruses evade the innate immune response by suppressing the production or activity of cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by which the SARS-CoV-2 virus coopts an intrinsic cellular machinery to sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6552dcb563bf1e40cb6a0eb4921c1a7c
https://pubmed.ncbi.nlm.nih.gov/35878012