Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Silvia Lima, Costa"'
Autor:
Daniele Silva Souza Carreira, Carolina Emy Sato, Waléria Borges da Silva, Thereza Cristina Borio dos Santos Calmon de Bittencourt, Silvia Lima Costa, Rosângela Soares Uzêda
Publikováno v:
Revista Brasileira de Parasitologia Veterinária, Vol 33, Iss 3 (2024)
Abstract Toxoplasma gondii is a coccidian protozoan of zoonotic importance that causes toxoplasmosis. Although the current treatments for toxoplasmosis may be associated with adverse effects and limited efficacy for different biological forms of the
Externí odkaz:
https://doaj.org/article/016e86fb03c64ef6a505b48d6c17f84d
Neuroprotective Effect of Flavonoid Agathisflavone in the Ex Vivo Cerebellar Slice Neonatal Ischemia
Autor:
Rodrigo Barreto Carreira, Cleonice Creusa dos Santos, Juciele Valeria Ribeiro de Oliveira, Victor Diogenes Amaral da Silva, Jorge Maurício David, Arthur Morgan Butt, Silvia Lima Costa
Publikováno v:
Molecules, Vol 29, Iss 17, p 4159 (2024)
Agathisflavone is a flavonoid that exhibits anti-inflammatory and anti-oxidative properties. Here, we investigated the neuroprotective effects of agathisflavone on central nervous system (CNS) neurons and glia in the cerebellar slice ex vivo model of
Externí odkaz:
https://doaj.org/article/bdd74db205f84682906d1a2ec664e273
Autor:
Monique Reis de Santana, Ylanna Bonfim dos Santos, Késsia Souza Santos, Manoelito Coelho Santos Junior, Mauricio Moraes Victor, Gabriel dos Santos Ramos, Ravena Pereira do Nascimento, Silvia Lima Costa
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 980 (2024)
The molecular mechanisms underlying the observed anticancer effects of flavonoids remain unclear. Increasing evidence shows that the aryl hydrocarbon receptor (AHR) plays a crucial role in neoplastic disease progression, establishing it as a potentia
Externí odkaz:
https://doaj.org/article/ed3c414fc77a498db16f9b03beb85d4e
Autor:
Rafael Short Ferreira, Paulo Roberto Ribeiro, Juliana Helena Castro e Silva, Juliana Bender Hoppe, Monique Marylin Alves de Almeida, Beatriz Correia de Lima Ferreira, Gustavo Borges Andrade, Suzana Braga de Souza, Luzimar Gonzaga Ferdandez, Maria de Fátima Dias Costa, Christianne Gazzana Salbego, Andrea Domenico Rivera, Aline Longoni, Adriano Martimbianco de Assis, Francesca Pieropan, José Cláudio Fonseca Moreira, Silvia Lima Costa, Arthur Morgan Butt, Victor Diogenes Amaral da Silva
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Stroke is a leading cause of death and disability worldwide. A major factor in brain damage following ischemia is excitotoxicity caused by elevated levels of the neurotransmitter glutamate. In the brain, glutamate homeostasis is a
Externí odkaz:
https://doaj.org/article/f8cd2f74dfeb4682a3778b317704dcf5
Autor:
Catarina de Jesus Nunes, Cinthia Cristina Santos, Erica Novaes Soares, Irlã Santos Lima, Uesley Vieira Alves, Emílio Lanna, Ronan Batista, Ravena Pereira do Nascimento, Silvia Lima Costa
Publikováno v:
Marine Drugs, Vol 22, Iss 6, p 235 (2024)
Neurodegenerative diseases involve neuroinflammation and a loss of neurons, leading to disability and death. Hence, the research into new therapies has been focused on the modulation of the inflammatory response mainly by microglia/macrophages. The e
Externí odkaz:
https://doaj.org/article/d578fbe9164a41cc9690950587c0ae45
Autor:
Érica Novaes Soares, Ana Carla dos Santos Costa, Gabriel de Jesus Ferrolho, Rodrigo Portes Ureshino, Bruk Getachew, Silvia Lima Costa, Victor Diogenes Amaral da Silva, Yousef Tizabi
Publikováno v:
Cells, Vol 13, Iss 6, p 474 (2024)
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neu
Externí odkaz:
https://doaj.org/article/1b2d12e45f5f4e76b51ef1e49c31f1ad
Autor:
Irlã Santos Lima, Érica Novaes Soares, Carolina Kymie Vasques Nonaka, Bruno Solano de Freitas Souza, Balbino Lino dos Santos, Silvia Lima Costa
Publikováno v:
Brain Sciences, Vol 14, Iss 1, p 90 (2024)
Glioblastoma (GBM) is the most aggressive and treatment-resistant brain tumor. In the GBM microenvironment, interaction with microglia is associated with the dysregulation of cytokines, chemokines, and miRNAs, contributing to angiogenesis, proliferat
Externí odkaz:
https://doaj.org/article/7b0516e7c4ad4a5cad5dcc7f25004d7b
Autor:
Mona N. Oliveira, Micheli M. Pillat, Juliana Baranova, Roberta Andrejew, Balbino Lino dos Santos, Silvia Lima Costa, Tamara T. Lah, Henning Ulrich
Publikováno v:
Advances in Cancer Biology - Metastasis, Vol 4, Iss , Pp 100045- (2022)
Glioblastoma (GB) is the most aggressive primary tumor of central nervous system, where no efficient therapy has been found so far. This is due to high intra- and inter- tumor heterogeneity, fast invasion and the therapy-resistant subpopulation of GB
Externí odkaz:
https://doaj.org/article/c0b9b387a0224c53a4200d495829d87b
Autor:
Balbino Lino dos Santos, Cleonice Creusa dos Santos, Janaina R. P. Soares, Karina C. da Silva, Juciele Valeria R. de Oliveira, Gabriele S. Pereira, Fillipe M. de Araújo, Maria de Fátima D. Costa, Jorge Mauricio David, Victor Diogenes A. da Silva, Arthur Morgan Butt, Silvia Lima Costa
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1410 (2023)
Agathisflavone, purified from Cenostigma pyramidale (Tul.) has been shown to be neuroprotective in in vitro models of glutamate-induced excitotoxicity and inflammatory damage. However, the potential role of microglial regulation by agathisflavone in
Externí odkaz:
https://doaj.org/article/46ce0413114040f591754b545aafa679
Autor:
Ana Elisa Del’Arco, Deivison Silva Argolo, Gilles Guillemin, Maria de Fátima Dias Costa, Silvia Lima Costa, Alexandre Moraes Pinheiro
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Neuroinflammation is one of the most frequently studied topics of neurosciences as it is a common feature in almost all neurological disorders. Although the primary function of neuroinflammation is to protect the nervous system from an insult, the co
Externí odkaz:
https://doaj.org/article/d48d0ba243b64798b8b1555337f4aec8