Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae

Autor: Silvia López-Argüello, Maria Montaner, Amanda Mármol-Salvador, Ana Velázquez-Escudero, Fernando Docobo-Pérez, Antonio Oliver, Bartolome Moya

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT The lack of effective first-line antibiotic treatments against Neisseria gonorrhoeae, and the worldwide dissemination of resistant strains, are the main drivers of a worsening global health crisis. β-lactam antibiotics have been the backbon

Externí odkaz: https://doaj.org/article/e492cafbdf964dcc85650c281de9f95e

Comparative analysis of in vitro dynamics and mechanisms of ceftolozane/tazobactam and imipenem/relebactam resistance development in Pseudomonas aeruginosa XDR high-risk clones

Autor: María A. Gomis-Font, Gabriel Cabot, Silvia López-Argüello, Laura Zamorano, Carlos Juan, Bartolomé Moyá, Antonio Oliver

Publikováno v: Journal of Antimicrobial Chemotherapy. 77:957-968

Objectives To analyse the dynamics and mechanisms of stepwise resistance development to ceftolozane/tazobactam and imipenem/relebactam in XDR Pseudomonas aeruginosa clinical strains. Methods XDR clinical isolates belonging to ST111 (main resistance m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8055433949abdf2dbd911cd7ea839d7b
https://doi.org/10.1093/jac/dkab496

Evolutionary conserved compositional structures hidden in genomes of the foot-and-mouth disease virus and of the human rhinovirus

Autor: Miguel Fuertes, Carlos Alonso, Silvia López-Argüello

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports

Picornaviridae family includes several viruses of great economic and medical importance. Among all members of the family we focused our attention on the human rhinovirus, the most important etiologic agent of the common cold and on the foot-and-mouth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2633d212801489118d07d304fb9ecc20
http://link.springer.com/article/10.1038/s41598-019-53013-8

Negatively charged amino acids at the foot-and-mouth disease virus capsid reduce the virion-destabilizing effect of viral RNA at acidic pH

Autor: Elisa Torres, Miguel A. Martín-Acebes, Rodrigo Cañas-Arranz, Silvia López-Argüello, Alicia Rodríguez-Huete, María J. Bustos, Mauricio G. Mateu, Flavia Caridi, Francisco Sobrino

Publikováno v: Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid

Elucidation of the molecular basis of the stability of foot-and-mouth disease virus (FMDV) particles is relevant to understand key aspects of the virus cycle. Residue N17D in VP1, located at the capsid inner surface, modulates the resistance of FMDV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df5f8a29f46185941a92b4881dbb1a0
http://europepmc.org/articles/PMC6997383

Thermostability of the foot-and-mouth disease virus capsid is modulated by lethal and viability-restoring compensatory amino acid substitutions

Autor: Alicia Rodríguez-Huete, Silvia López-Argüello, Mauricio G. Mateu, Alejandro Valbuena, Graham J. Belsham, Verónica Rincón, Encarnación Martínez-Salas

Publikováno v: López-Argüello, S, Rincón, V, Rodríguez-Huete, A, Martínez-Salas, E, Belsham, G, Valbuena, A & Mateu, M G 2019, ' Thermostability of the Foot-and-Mouth Disease Virus Capsid Is Modulated by Lethal and Viability-Restoring Compensatory Amino Acid Substitutions ', Journal of Virology, vol. 93, no. 10, e02293-18 . https://doi.org/10.1128/JVI.02293-18
Digital.CSIC. Repositorio Institucional del CSIC
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Infection by viruses depends on a balance between capsid stability and dynamics. This study investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893bbca8573c9a3a06b21772a8800522
https://doi.org/10.1128/jvi.02293-18