Výsledky vyhledávání - "Silvia K. Schmidt"

Akademický článek

Cytomegalovirus impairs the induction of indoleamine 2,3-dioxygenase mediated antimicrobial and immunoregulatory effects in human fibroblasts.

Autor: Kathrin Heseler, Silvia K Schmidt, Katrin Spekker, Christian Sinzger, Rüdiger V Sorg, Marc Quambusch, Albert Zimmermann, Roland Meisel, Walter Däubener

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64442 (2013)

Human fibroblasts provide immunosuppressive functions that are partly mediated by the tryptophan-catabolizing enzyme indoleamine-2,3-dioxygenase (IDO). Moreover, upon stimulation with inflammatory cytokines human fibroblasts exhibit broad-spectrum an

Externí odkaz: https://doaj.org/article/27fcaeee473f457d9e7fc5a9ca02d170

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Akademický článek

Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions.

Autor: Silvia K Schmidt, Sebastian Ebel, Eric Keil, Claudia Woite, Joachim F Ernst, Anika E Benzin, Jan Rupp, Walter Däubener

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63301 (2013)

Tryptophan is an essential amino acid for human beings as well as for some microorganisms. In human cells the interferon-γ (IFN-γ) inducible enzyme indoleamine 2,3-dioxygenase (IDO) reduces local tryptophan levels and is therefore able to mediate b

Externí odkaz: https://doaj.org/article/9cf62519c70e46eaa41486ac72ffec3c

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Source attribution of community-acquired cases of Legionnaires’ disease–results from the German LeTriWa study; Berlin, 2016–2019

Autor: Madlen Koch, Edith Harbich, Ute Geuß-Fosu, Silvia K. Schmidt, Steffen Behrens, Andreas Beyer, Udo Buchholz, Jacqueline Bochmann, Fabian Stemmler, Patrick Larscheid, Birte Schilling, Walter Haas, Nicoletta Wischnewski, Verena Moos, Maria-Barbara Naumann, Dorina Thiemig, Stefan Kahl, Yvonne Schreiner, Benedikt Schaefer, Denis Hedeler, Franziska Reber, Johannes Elias, Bernd Schmidt, Corinna Gagell, Gudrun Widders, Klaus Morawski, Martina Gregor, Irina Zuschneid, Lukas Murajda, Christina Förster, Heiko J. Jahn, Viktor Kimmel, Martina Hänel, Raimund Pitzing, Iskandar Atmowihardjo, Henning Kahnert, Kristin Adler, Hans Scherübl, Wulf Pankow, Norbert Suttorp, Inas Abdelgawad, Uwe Mannschatz, Christian Lück, Agata Mikolajewska, Hartmut Stocker, Bonita Brodhun, Pascal Migaud, Sina Bärwolff, Carsten Gollnisch, Keikawus Arastéh, Ann-Sophie Lehfeld, Josefa Lehmke, Marina M. Lewandowsky, Uwe Peters, Petra Creutz, Thomas Schneider, Jakob Schumacher, Andreas von Welczeck, Anke Hinzmann

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0241724 (2020)

Introduction Sources of infection of most cases of community-acquired Legionnaires’ disease (CALD) are unknown. Objective Identification of sources of infection of CALD. Setting Berlin; December 2016–May 2019. Participants Adult cases of CALD rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a55ef008f9e42b09423395399f3658
http://europepmc.org/articles/PMC7688155

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Akademický článek

Influence of tryptophan contained in 1-Methyl-Tryptophan on antimicrobial and immunoregulatory functions of indoleamine 2,3-dioxygenase.

Autor: Silvia K Schmidt, Stephan Siepmann, Katja Kuhlmann, Helmut E Meyer, Sabine Metzger, Sabine Pudelko, Margret Leineweber, Walter Däubener

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44797 (2012)

Indoleamine 2,3-dioxygenase (IDO) has been identified as an important antimicrobial and immunoregulatory effector molecule essential for the establishment of tolerance by regulating local tryptophan (Trp) concentrations. On the other hand, the immuno

Externí odkaz: https://doaj.org/article/3dedfd2effa6427cb5bee0e5413464a4

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Risikofaktoren für den Erwerb einer sporadischen ambulant erworbenen Legionärskrankheit: Zwischenergebnisse der Berliner LeTriWa-Studie zu Legionellen im Trinkwasser

Autor: Bernd Schmidt, Franziska Reber, Henning Kahnert, Wulf Pankow, Irina Zuschneid, Bonita Brodhun, S Maeusel, HJ Jahn, Ann-Sophie Lehfeld, Josefa Lehmke, Ute Geuß-Fosu, B Wilbrandt, Andreas Beyer, Uwe Peters, Agata Mikolajewska, Walter Haas, Jakob Schumacher, Klaus Morawski, M Pross, Nicoletta Wischnewski, R Leistner, Andreas von Welczeck, Keikawus Arastéh, Viktor Kimmel, P Gastmeier, Verena Moos, N Gehrmann-Sommer, Benedikt Schaefer, I Abdelgavad, Stefan Kahl, V Kalisch, E Schöne, N Dinsel, Steffen Behrens, I Bressem, A Sturm, Anke Hinzmann, Maria-Barbara Naumann, C Brandt, Petra Creutz, Thomas Schneider, D Sissolak, M Abel, L Müller, Raimund Pitzing, M Weisker, E Nürnberger, Dorina Thiemig, Martina Hänel, J Danckert, Fabian Stemmler, C Otto, Hartmut Stocker, Pascal Migaud, Johannes Elias, Corinna Gagell, Martina Gregor, A Awlakpui, Udo Buchholz, RA Laun, Patrick Larscheid, Sina Bärwolff, B Deparade-Berger, Gudrun Widders, Hans Scherübl, AK Geers, Christian Lück, P Mähl, Silvia K. Schmidt, Birte Schilling

Publikováno v: 69. Wissenschaftlicher Kongress des Bundesverbandes der Ärztinnen und Ärzte des Öffentlichen Gesundheitsdienstes (BVÖGD) und des Bundesverbandes der Zahnärzte des Öffentlichen Gesundheitsdienstes (BZÖG) in Zusammenarbeit mit der Gesellschaft Hygiene, Umweltmedizin und Präventivmedizin (GHUP).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e047eb9e31386f796234b4c6e4ac914a
https://doi.org/10.1055/s-0039-1679280

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Checks and balances between human cytomegalovirus replication and indoleamine-2,3-dioxygenase

Autor: Sebastian Hauka, Silvia K. Schmidt, Vu Thuy Khanh Le, Walter Däubener, Marco Maywald, Hartmut Hengel, Albert Zimmermann

Publikováno v: Journal of General Virology. 95:659-670

Despite a rigorous blockade of interferon-γ (IFN-γ) signalling in infected fibroblasts as a mechanism of immune evasion by human cytomegalovirus (HCMV), IFN-γ induced indoleamine-2,3-dioxygenase (IDO) has been proposed to represent the major antiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0b9ff0edb4ec1d00bc6c79f1f82e03
https://doi.org/10.1099/vir.0.061994-0

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Indoleamine 2,3-Dioxygenase Is Involved in Defense againstNeospora caninumin Human and Bovine Cells

Autor: Walter Däubener, Kathrin Heseler, V. Ince, Markus Czesla, Gereon Schares, Silvia K. Schmidt, K. Spekker

Publikováno v: Infection and Immunity. 77:4496-4501

Neospora caninumis an apicomplexan parasite closely related toToxoplasma gondii. In nature this parasite is found especially in dogs and cattle, but it may also infect other livestock. The growth ofN. caninum, which is an obligate intracellular paras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643ec136b5b66483afbb68bd61be1481
https://doi.org/10.1128/iai.00310-09

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Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs)

Autor: Daniel Degrandi, Stuhlsatz S, Jochen Seissler, Andrew Hemphill, Özer Degistirici, Klaus Pfeffer, S. Brunder, V. Ince, Jonathan C. Howard, M. Leineweber, Silvia K. Schmidt, Roland Meisel, K. Spekker, Walter Däubener, Rüdiger V. Sorg, Gereon Schares

Publikováno v: Spekker, K.; Leineweber, M.; Degrandi, D.; Ince, V.; Brunder, S.; Schmidt, S. K.; Stuhlsatz, S.; Howard, J. C.; Schares, G.; Degistirici, O.; Meisel, R.; Sorg, R. V.; Seissler, J.; Hemphill, Andrew; Pfeffer, K.; Däubener, W. (2013). Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs). Medical microbiology and immunology, 202(3), pp. 197-206. Springer 10.1007/s00430-012-0281-y
Medical microbiology and immunology

Mesenchymal stromal cells (MSCs) have a multilineage differentiation potential and provide immunosuppressive and antimicrobial functions. Murine as well as human MSCs restrict the proliferation of T cells. However, species-specific differences in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6376dc6c8f3e20596dc7389f58ff4a4
https://boris.unibe.ch/44749/1/art_10.1007_s00430-012-0281-y.pdf

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Regulation of IDO activity by oxygen supply: inhibitory effects on antimicrobial and immunoregulatory functions

Autor: Claudia Woite, Jan Rupp, Sebastian Ebel, Anika E. Benzin, Silvia K. Schmidt, Joachim F. Ernst, Eric Keil, Walter Däubener

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e63301 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee248cc0d071e78754f0a982d54ed2d
https://pubmed.ncbi.nlm.nih.gov/23675474

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