Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection

Autor: Andrés Sanchez Alberti, Augusto E. Bivona, Natacha Cerny, Kai Schulze, Sebastian Weißmann, Thomas Ebensen, Celina Morales, Angel M. Padilla, Silvia I. Cazorla, Rick L. Tarleton, Carlos A. Guzmán, Emilio L. Malchiodi

Publikováno v: npj Vaccines, Vol 2, Iss 1, Pp 1-12 (2017)

Chagas disease: protecting from chronic parasitic disease An amalgamation of parasitic proteins may be the first effective vaccine against the as yet untreatable chronic phase of Chagas disease. The infliction, caused by the parasite Trypanosoma cruz

Externí odkaz: https://doaj.org/article/ae1f0273188b48babe69f8e20ee1e766

Oral Administration of Probiotics Increases Paneth Cells and Intestinal Antimicrobial Activity

Autor: Silvia I. Cazorla, Carolina Maldonado-Galdeano, Ricardo Weill, Juan De Paula, Gabriela D. V. Perdigón

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

The huge amount of intestinal bacteria represents a continuing threat to the intestinal barrier. To meet this challenge, gut epithelial cells produce antimicrobial peptides (AMP) that act at the forefront of innate immunity. We explore whether this a

Externí odkaz: https://doaj.org/article/18c920aa286843608be42d09f4094f1c

In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species

Autor: Laura C. Laurella, Fernanda M. Frank, Andrea Sarquiz, María R. Alonso, Gustavo Giberti, Lucia Cavallaro, Cesar A. Catalán, Silvia I. Cazorla, Emilio Malchiodi, Virginia S. Martino, Valeria P. Sülsen

Publikováno v: The Scientific World Journal, Vol 2012 (2012)

The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosom

Externí odkaz: https://doaj.org/article/581b7dc9afd9473f87164373be1f0696

Trypanocidal activity of four sesquiterpene lactones isolated from Asteraceae species

Autor: Augusto Ernesto Bivona, Orlando German Elso, Celina Morales, Natacha Cerny, Valeria P. Sülsen, Silvia I. Cazorla, César A.N. Catalán, Andrés Sanchez Alberti, Emilio L. Malchiodi, Lucas Fabian

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Molecules
Volume 25
Issue 9
Molecules, Vol 25, Iss 2014, p 2014 (2020)

The sesquiterpene lactones eupatoriopicrin, estafietin, eupahakonenin B and minimolide have been isolated from Argentinean Astearaceae species and have been found to be active against Trypanosoma cruzi epimastigotes. The aim of this work was to evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea171f43904b088e9a42a451446504bb
https://www.mdpi.com/1420-3049/25/9/2014

Mucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against

Autor: Andrés Sanchez Alberti, Augusto E. Bivona, Marina N. Matos, Natacha Cerny, Kai Schulze, Sebastian Weißmann, Thomas Ebensen, Germán González, Celina Morales, Alejandro C. Cardoso, Silvia I. Cazorla, Carlos A. Guzmán, Emilio L. Malchiodi

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

There are several unmet needs in modern immunology. Among them, vaccines against parasitic diseases and chronic infections lead. Trypanosoma cruzi, the causative agent of Chagas disease, is an excellent example of a silent parasitic invasion that aff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb010de1158b8e3aa8898593996f176
https://pubmed.ncbi.nlm.nih.gov/32153562