Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Silvia I. Pomposiello"'
Autor:
Kaliappan Iyanar, Jessica D. Dietz, Graciela B. Arhancet, Horng-Chih Huang, Danny J. Garland, Marcia I. Heron, Silvia I. Pomposiello, Xiao Hu, Len F. Lee, Joe T. Collins, Scott S. Woodard, James Robert Blinn, Maria A. Payne, Brenda L. Case, Rhonda S. Woerndle
Publikováno v:
Journal of Medicinal Chemistry. 53:5970-5978
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9288e4053ed7e7f775bce265c4ec3184
https://doi.org/10.1021/jm100506y
https://doi.org/10.1021/jm100506y
Publikováno v:
Journal of Cardiovascular Pharmacology. 34:567-574
Although endothelium-derived hyperpolarizing factor (EDHF) is thought to be a cytochrome P-450 product (arachidonic acid metabolite) in some tissues, in porcine coronary arteries (PCAs) its nature remains unclear. Because phospholipase A2 and C are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a0c2aecdee8bdaa6a2d03e79900bfd
https://doi.org/10.1097/00005344-199910000-00014
https://doi.org/10.1097/00005344-199910000-00014
Publikováno v:
Hypertension. 31:615-620
Abstract —Linoleic acid, a polyunsaturated C 18 fatty acid, is one of the major fatty acids in the coronary arterial wall. Although diets rich in linoleic acid reduce blood pressure and prevent coronary artery disease in both humans and animals, ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e5ed32338e1eea843a4cfdd0ac78ef
https://doi.org/10.1161/01.hyp.31.2.615
https://doi.org/10.1161/01.hyp.31.2.615
Publikováno v:
American Journal of Physiology-Renal Physiology. 270:F206-F210
Nitric oxide (NO) reduces blood pressure in vivo by two mechanisms, vasodilation and increasing urinary volume: however, the exact mechanism by which it increases urinary volume is not clear. We hypothesized that NO inhibits antidiuretic hormone (ADH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d9b713b28c40472dc764f87e206dba
https://doi.org/10.1152/ajprenal.1996.270.1.f206
https://doi.org/10.1152/ajprenal.1996.270.1.f206
Autor:
Jane R. Connor, Maria A. Payne, Silvia I. Pomposiello, John J. Kotyk, Pamela T. Manning, Linda F. Branson, Steven J. Baldwin
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ad71c4f378537c95cc54ef2bef5bc54
https://doi.org/10.1096/fasebj.20.5.a1138-b
https://doi.org/10.1096/fasebj.20.5.a1138-b
5,6-epoxyeicosatrienoic acid mediates the enhanced renal vasodilation to arachidonic acid in the SHR
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 42(4)
We have shown a cytochrome P450–dependent renal vasodilator effect of arachidonic acid in response to inhibition of cyclooxygenase and elevation of perfusion pressure, which was enhanced in the spontaneously hypertensive rat (SHR) and linked to inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e6a1ec5595e3869f6a1ae52b222820
https://pubmed.ncbi.nlm.nih.gov/12939232
https://pubmed.ncbi.nlm.nih.gov/12939232
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 37(3)
We tested the hypothesis that cyclooxygenase-independent vasodilation produced by arachidonic acid (AA) is mediated by epoxyeicosatrienoic acids (EETs) and is blunted in the spontaneously hypertensive rat (SHR). At normal perfusion pressure (PP; 70 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1296564a5fda4998b7f72ef3bd1655
https://pubmed.ncbi.nlm.nih.gov/11244013
https://pubmed.ncbi.nlm.nih.gov/11244013
Autor:
Michael Sevilla, Mahender Surakanti, Xiao-Ping Yang, Nour Eddine Rhaleb, Silvia I. Pomposiello, Oscar A. Carretero, Yun-He Liu
Publikováno v:
Journal of cardiovascular pharmacology. 30(5)
Inhibition of nitric oxide (NO) synthesis results in coronary vasoconstriction. Using a Langendorff rat heart preparation, we tested the hypothesis that this vasoconstriction is caused by the unopposed effect of the autacoids prostaglandin H2 (PGH2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8f62307907846f09e3a81e1031c3e4
https://pubmed.ncbi.nlm.nih.gov/9388042
https://pubmed.ncbi.nlm.nih.gov/9388042
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 29(1 Pt 2)
Renal kinins release prostaglandins and nitric oxide via the B 2 receptor, promoting diuresis and natriuresis; hence, they may also contribute significantly to blood pressure regulation. We hypothesized that mutant mice lacking the gene encoding for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c38b23ae1558336b7f780497eea4aa3
https://pubmed.ncbi.nlm.nih.gov/9039146
https://pubmed.ncbi.nlm.nih.gov/9039146
Publikováno v:
Hypertension. 36:713-713
P109 The cytochrome P450-dependent renal vasodilator effect of arachidonic acid (AA) that is expressed when cyclooxygenase is inhibited and perfusion pressure (PP) is elevated, is enhanced in SHR. In kidneys perfused with Krebs’ solution and precon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bd6af795414dbc821ae28f75a2d0078
https://doi.org/10.1161/hyp.36.suppl_1.713
https://doi.org/10.1161/hyp.36.suppl_1.713