Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma

Autor: Véronique N Lafleur, Silvia Halim, Hani Choudhry, Peter J Ratcliffe, David R Mole

Hypoxia-inducible factor (HIF) and aryl hydrocarbon receptor (AHR) are members of the bHLH-PAS family of transcription factors that underpin cellular responses to oxygen and to endogenous and exogenous ligands, respectively, and have central roles in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68de98ce1d07927fdc7325dfd7266d03

Abstract 119: Pan-cancer analysis of HIF pathways defines a robust molecular signature that reflects tissue and cellular hypoxia in bulk and single-cell RNA-seq analyses

Autor: Olivia Lombardi, Ran Li, Silvia Halim, Peter J. Ratcliffe, David R. Mole

Publikováno v: Cancer Research. 82:119-119

Low levels of tissue oxygen, or intra-tumor hypoxia, is a common feature of many solid cancers in which dysregulated cell proliferation often outstrips the ability to develop new functional blood vessels. Furthermore, hypoxia pathways may also be act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75c4946159d25a2da40d0147e5985a3d
https://doi.org/10.1158/1538-7445.am2022-119

Gene regulatory mechanisms underpinning prostate cancer susceptibility

Autor: Johan Lindberg, Robert Karlsson, Tom Whitington, Ping Gao, Daniel Klevebring, Henrik Grönberg, Silvia Halim, David E. Neal, Anne Y. Warren, Mark J Dunning, Lars Egevad, Fredrik Wiklund, Ilaria Svezia, Wei Song, Gong-Hong Wei, Yuehong Yang, Alastair D. Lamb, Ian G. Mills, Helen Ross-Adams

Publikováno v: Nature Genetics. 48:387-397

Thomas Whitington and colleagues present a detailed characterization of gene regulatory mechanisms underlying prostate cancer susceptibility. Their analysis highlights key mechanisms altered by disease-associated SNPs, including widespread disruption

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0904cc42bd9f8397ed5fb37e24bb525
https://doi.org/10.1038/ng.3523

Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study

Autor: Theodorus van der Kwast, Xianyue Meng, Rosalind A. Eeles, David E. Neal, Jenna Sykes, Silvia Halim, Lauren C. Chong, Igor Jurisica, Lucia L. Lam, Alastair D. Lamb, Elai Davicioni, Denise Y.F. Mak, Wan L. Lam, Kenneth C. Chu, Helen Ross-Adams, Michael Milosevic, Nicholas Erho, John Thoms, Anne Y. Warren, Alejandro Berlin, Chad A. Malloff, Mark J Dunning, Emilie Lalonde, Honglei Xie, Melania Pintilie, CQ Yao, Cherry Have, Dorota H. Sendorek, Nicholas J. Harding, Robert G. Bristow, Michael Fraser, Christine P'ng, Jeremy A. Squire, Alan Dal Pra, Colin Cooper, Colin Collins, Michal R. Grzadkowski, Varune Rohan Ramnarine, Nathalie C. Moon, Gaetano Zafarana, Adrian Ishkanian, Paul C. Boutros

Publikováno v: The Lancet Oncology. 15(13):1521-1532

Summary Background Clinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0107946531f1f7f4fc6ee2ec369e5cab

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Autor: Mohammad Asim, Silvia Halim, Martin Mørck Mortensen, Hayley C. Whitaker, Adele Murrell, Anne Y. Warren, Simon A. Gayther, Alastair D. Lamb, Ian G. Mills, Jonathan D. Kay, Stephen J. Ball, Sebastian M. Armasu, Antonio Ramos-Montoya, Karina Dalsgaard Sørensen, Siri H. Strand, Claire M. Wells, Michael Borre, Kathryn Woodfine, Melissa C. Larson, Charles E. Massie, Kate Lawrenson, Ellen L. Goode, David E. Neal, Roslin Russell, Torben F. Ørntoft, Brooke L. Fridley, John R. W. Masters, Helen Ross-Adams

Publikováno v: Ross-Adams, H, Ball, S, Lawrenson, K, Halim, S, Russell, R, Wells, C, Strand, S H, Ørntoft, T F, Larson, M, Armasu, S, Massie, C E, Asim, M, Mortensen, M M, Borre, M, Woodfine, K, Warren, A Y, Lamb, A D, Kay, J, Whitaker, H, Ramos-Montoya, A, Murrell, A, Sørensen, K D, Fridley, B L, Goode, E L, Gayther, S A, Masters, J, Neal, D E & Mills, I G 2016, ' HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer ', Oncotarget, vol. 7, no. 46, pp. 74734-74746 . https://doi.org/10.18632/oncotarget.12543
Ross-Adams, H, Ball, S, Lawrenson, K, Halim, S, Russell, R, Wells, C, Strand, S H, Ørntoft, T F, Larson, M, Armasu, S, Massie, C E, Asim, M, Mortensen, M M, Borre, M, Woodfine, K, Warren, A Y, Lamb, A D, Kay, J, Whitaker, H, Ramos-Montoya, A, Murrell, A, Sørensen, K D, Fridley, B L, Goode, E L, Gayther, S A, Masters, J, Neal, D E & Mills, I G 2016, ' HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer ', Oncotarget . https://doi.org/10.18632/oncotarget.12543
Oncotarget
Ross-Adams, H, Ball, S J, Lawrenson, K, Halim, S, Russell, R, Wells, C, Strand, S, Ørntoft, T F, Larson, M C, Armasu, S M, Massie, C E, Asim, M, Mortensen, M M, Borre, M, Woodfine, K, Warren, A Y, Lamb, A D, Kay, J, Whitaker, H, Ramos-Montoya, A, Murrell, A, Sørensen, K D, Fridley, B L, Goode, E L, Gayther, S A, Masters, J R, Neal, D E & Mills, I G 2016, ' HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer ', OncoTarget, vol. 7, no. 46, pp. 74734-74746 . https://doi.org/10.18632/oncotarget.12543

Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1087fbe6b7f09cc62ecb72e3ad4e3d33
https://kclpure.kcl.ac.uk/en/publications/9de950f5-0783-47e3-8734-2c4c386c1c49