Výsledky vyhledávání - "Silvia Haffner"

Mesenchymal Stromal Cells Protect Endothelial Cells from Cytotoxic T Lymphocyte-Induced Lysis

Autor: Silvia Haffner, Ornella Parolini, Barbara Holler, Ralf Huss, Christine Günther, Emer F. Cahill, Isabel Hartmann, Tanja Sax, Günther Eissner, Ernst Holler, Walter Kolch

Publikováno v: Scandinavian journal of immunology. 84(3)

The integrity of the vasculature plays an important role in the success ofallogeneic organ and haematopoietic stem cell transplantation. Endothelial cells(EC) have previously been shown to be the target of activated cytotoxic Tlymphocytes (CTL) resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adf30270a9a5b7f715efae5eed72519
https://pubmed.ncbi.nlm.nih.gov/27384426

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Umbilical cord tissue-derived mesenchymal stem cells grow best under GMP-compliant culture conditions and maintain their phenotypic and functional properties

Autor: Isabel Hartmann, Michaela Krebs, Bruno Meiser, Bruno Reichart, Trixi Hollweck, Günther Eissner, Silvia Haffner

Publikováno v: Journal of Immunological Methods. 363:80-89

Mesenchymal stem cells (MSCs) are fibroblast-like multipotent stem cells that can differentiate into cell types of mesenchymal origin. Because of their immune properties and differentiation, potential MSCs are discussed for the use in tissue regenera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957eff6b3079092ff87ba8ed20a6e86b
https://doi.org/10.1016/j.jim.2010.10.008

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Defibrotide: An endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo

Autor: Caroline Frei, Verena Burger, Ernst Holler, Silvia Haffner, Hans J. Schlitt, Gudrun E. Koehl, Edward K. Geissler, Massimo Iacobelli, Reinhard Andreesen, Günther Eissner

Publikováno v: Cancer Biology & Therapy. 6:686-690

Defibrotide (DF) is a polydisperse mixture of 90% single-stranded oligonucleotides with anti-thrombotic and anti-apoptotic functions. DF is used in the treatment of endothelial complications in the course of allogeneic stem cell transplantation. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04389f84af830a694f29d247ed8d126
https://doi.org/10.4161/cbt.6.5.3959

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Effect of different tumor necrosis factor (TNF) reactive agents on reverse signaling of membrane integrated TNF in monocytes

Autor: Silvia Haffner, Silvia Kirchner, Günther Eissner, Ernst Holler, Reinhard Andreesen

Publikováno v: Cytokine. 28:67-74

Reverse signaling of transmembrane TNF (mTNF) contributes to the versatility of this cytokine superfamily. Previously, we could demonstrate that mTNF acting as receptor confers resistance to bacterial lipopolysaccharide in monocytes and macrophages (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ea57bd3c7ea9f500a0edfa019074b4
https://doi.org/10.1016/j.cyto.2004.06.008

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Differentiation of human tumour-associated dendritic cells into endothelial-like cells: an alternative pathway of tumour angiogenesis

Autor: Marina Kreutz, Ernst Holler, Günther Eissner, Massimo Iacobelli, Silvia Haffner, Reinhard Andreesen, Eva Gottfried

Publikováno v: Scandinavian journal of immunology. 65(4)

Until recently, the only accepted mechanism of tumour vascularization was the sprouting of endothelial cells (EC) from pre-existing vessels, while recent studies suggest the contribution of stem cell-derived endothelial progenitors as well as cells f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9dbb5b0fae87eaf1dfd2b5c9d7fa2c5
https://pubmed.ncbi.nlm.nih.gov/17386023

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Oligotide, a defibrotide derivative, protects human microvascular endothelial cells against fludarabine-induced activation, damage and allogenicity

Autor: S. Blüml, Günther Eissner, Massimo Iacobelli, Reinhard Andreesen, Silvia Haffner, Verena Burger, Ernst Holler

Publikováno v: Bone marrow transplantation. 35(9)

Fludarabine is a nonmyeloablative immunosuppressant increasingly used as a component of alternative reduced-intensity conditioning regimens prior to allogeneic stem cell transplantation (SCT). However, we have previously shown that 2-fluoroadenine 9-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314f0207af134deb382a22e336f6f97f
https://pubmed.ncbi.nlm.nih.gov/15778728

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LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway

Autor: Walter Kolch, Petra Janosch, Reinhard Andreesen, Simone Boldt, Seran Kazak, Silvia Kirchner, Günther Eissner, Ernst Holler, Silvia Haffner

Publikováno v: Journal of leukocyte biology. 75(2)

The transmembrane form of tumor necrosis factor (mTNF), expressed on activated monocytes (MO) and macrophages (MΦ), is able to induce apoptosis in human endothelial cells (EC). Apoptosis is mediated by two distinct mechanisms: direct cell contact an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1487ee0c7fc957e7901ea143fd9db0f1
https://pubmed.ncbi.nlm.nih.gov/14612430

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Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide

Autor: Silvia Haffner, Sonja Bauer, Silvia Kirchner, Reinhard Andreesen, Günther Eissner, Gabriele Multhoff, Daniela Sondermann, Armin Gerbitz, Ernst Holler

Publikováno v: Blood. 100(1)

Fludarabine is a nonmyeloablative immunosuppressant increasingly used as a component of alternative conditioning regimens before allogeneic bone marrow transplantation. It is expected to reduce conditioning-related toxicity and proinflammatory activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5e53f95e3fa1a5965f9b0055dbd368
https://pubmed.ncbi.nlm.nih.gov/12070045

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