Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Silvia H, Fernández Villamil"'
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0267329 (2022)
Poly (ADP-ribose) polymerase (PARP) is responsible for the synthesis of ADP-ribose polymers, which are involved in a wide range of cellular processes such as preservation of genome integrity, DNA damage signaling and repair, molecular switches betwee
Externí odkaz:
https://doaj.org/article/1bf090ac07cd4708815d5d4d59a1b710
Autor:
Salomé Vilchez Larrea, Wanda Mariela Valsecchi, Silvia H. Fernández Villamil, Laura I. Lafon Hughes
Publikováno v:
PeerJ, Vol 9, p e11442 (2021)
Background Adherens junctions (AJ) are involved in cancer, infections and neurodegeneration. Still, their composition has not been completely disclosed. Poly(ADP-ribose) polymerases (PARPs) catalyze the synthesis of poly(ADP-ribose) (PAR) as a posttr
Externí odkaz:
https://doaj.org/article/b55f7cc6be6f49019c1d15e1e7e18471
Autor:
Teemu Haikarainen, Mariana Schlesinger, Ezeogo Obaji, Silvia H. Fernández Villamil, Lari Lehtiö
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Trypanosoma brucei is a unicellular parasite responsible for African trypanosomiasis or sleeping sickness. It contains a single PARP enzyme opposed to many higher eukaryotes, which have numerous PARPs. PARPs are responsible for a post-transl
Externí odkaz:
https://doaj.org/article/383567bfb60a4e1f9f36829cf9b4a8ca
Publikováno v:
Parasitology. 148:1680-1690
Chagas disease is a potentially life-threatening protozoan infection affecting around 8 million people, for which only chemotherapies with limited efficacy and severe adverse secondary effects are available. The aetiological agent, Trypanosoma cruzi,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd802b6cf2b665247c9ee74c95d952e
https://doi.org/10.1017/s0031182021001402
https://doi.org/10.1017/s0031182021001402
Autor:
Laura I. Lafon Hughes, Carlos J. Romeo Cardeillac, Karina B. Cal Castillo, Salomé C. Vilchez Larrea, José R. Sotelo Sosa, Gustavo A. Folle Ungo, Silvia H. Fernández Villamil, Alejandra E. Kun González
Publikováno v:
PeerJ, Vol 5, p e3318 (2017)
Background Poly-ADP-ribose (PAR) is a polymer synthesized by poly-ADP-ribose polymerases (PARPs) as a postranslational protein modification and catabolized mainly by poly-ADP-ribose glycohydrolase (PARG). In spite of the existence of cytoplasmic PARP
Externí odkaz:
https://doaj.org/article/cd5c6d925d744b3a88fa733db2a8170b
Publikováno v:
Parasitology. 148(13)
Chagas disease is a potentially life-threatening protozoan infection affecting around 8 million people, for which only chemotherapies with limited efficacy and severe adverse secondary effects are available. The aetiological agent, Trypanosoma cruzi,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bf728fca8cd8bd9e7f7a05f18093e20
https://pubmed.ncbi.nlm.nih.gov/35060470
https://pubmed.ncbi.nlm.nih.gov/35060470
Publikováno v:
PeerJ, Vol 2, p e617 (2014)
Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG). Nuclear PAR modulates chromatin compaction, affecting nuclear functions (gene e
Externí odkaz:
https://doaj.org/article/463205f743084d8e8c6ee352b0da3109
Autor:
Salomé C Vilchez Larrea, Mariana Schlesinger, María L Kevorkian, Mirtha M Flawiá, Guillermo D Alonso, Silvia H Fernández Villamil
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67356 (2013)
Trypanosoma cruzi, etiological agent of Chagas' disease, has a complex life cycle which involves the invasion of mammalian host cells, differentiation and intracellular replication. Here we report the first insights into the biological role of a poly
Externí odkaz:
https://doaj.org/article/cafd465d800c4286a25f56597225f3b2
Publikováno v:
Acta tropica. 208
Poly(ADP-ribosyl)ation reactions constitute a post-translational protein modification synthesized in higher eukaryotes by a family of poly(ADP-ribose)polymerases (PARP) and catabolized mainly by poly(ADP-ribose) glycohydrolase (PARG). The best unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ead338428edf3bc2a3a9328b3d0975
https://pubmed.ncbi.nlm.nih.gov/32330449
https://pubmed.ncbi.nlm.nih.gov/32330449
Autor:
Salomé C Vilchez Larrea, Teemu Haikarainen, Mohit Narwal, Mariana Schlesinger, Harikanth Venkannagari, Mirtha M Flawiá, Silvia H Fernández Villamil, Lari Lehtiö
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46063 (2012)
Poly(ADP-ribosylation) is a post-translational covalent modification of proteins catalyzed by a family of enzymes termed poly(ADP-ribose) polymerases (PARPs). In the human genome, 17 different genes have been identified that encode members of the PAR
Externí odkaz:
https://doaj.org/article/4f1ce57c0d7f44758a1fe1246f865b22