Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Silvia Gual"'
Autor:
Laura Vidal, Sonia Sentellas, Gema Tarrasón, Soledad Alzina, Silvia Gual, Bernat Vidal, Cristina Esteve, Irene Jover, Jacob González, Jorge De Alba, Montserrat Miralpeix, Raquel Horrillo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1217-1222
Synthesis and SAR of a series of 7-azaindoles as Orai channel inhibitors showing good potency inhibiting IL-2 production in Jurkat cells is described. Compound 14d displaying best pharmacokinetic properties was further characterized in a model of all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825a7ee7d35a2e46075e136353eb9a3f
https://doi.org/10.1016/j.bmcl.2015.01.063
https://doi.org/10.1016/j.bmcl.2015.01.063
Autor:
Yongsheng Chen, Mark Santos, Emily Lin, Stacy Markison, John E. Tellew, Sandra M. Lechner, Maria Prat, Xiaohu Zhang, John Saunders, Silvia Gual, Marion Lanier, Marı´a I. Crespo, John P. Williams, Raymond S. Gross, Tanya Joswig, Jaimie K. Rueter, Deborah H. Slee, Siobhan Malany, Jose-Luis Diaz, Manisha Moorjani, Julio C. Castro-Palomino
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1778-1783
A series of N-pyrimidinyl-2-phenoxyacetamide adenosine A(2A) antagonists is described. SAR studies led to compound 14 with excellent potency (K(i) = 0.4 nM), selectivity (A(1)/A(2A) > 100), and efficacy (MED 10 mg/kg p.o.) in the rat haloperidol-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dca2261358c58ec30c26ccccacb9f1
https://doi.org/10.1016/j.bmcl.2008.02.032
https://doi.org/10.1016/j.bmcl.2008.02.032
Autor:
Stacy Markison, Sandra M. Lechner, John Saunders, John P. Williams, Silvia Gual, Siobhan Malany, Jaimie K. Rueter, Maria Prat, Raymond S. Gross, Julio C. Castro-Palomino, Tanya Joswig, Kayvon Jalali, Zhiyang Zuo, Manisha Moorjani, Deborah H. Slee, Jose-Luis Diaz, Robert E. Petroski, María I. Crespo, Chun Yang, Yang Sai, Emily Lin, Zhihong O’Brien, Marion Lanier, Xiaohu Zhang, Jenny Wen, Mark Santos, Yongsheng Chen
Publikováno v:
Journal of medicinal chemistry. 51(6)
Previously we have described a series of novel A 2A receptor antagonists with excellent water solubility. As described in the accompanying paper, the antagonists were first optimized to remove an unsubstituted furyl moiety, with the aim of avoiding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226a608572d86ea3081c27e5732dbbd6
https://pubmed.ncbi.nlm.nih.gov/18307293
https://pubmed.ncbi.nlm.nih.gov/18307293
Autor:
Silvia Gual, Chun Yang, Yang Sai, Kayvon Jalali, Sandra M. Lechner, Marion Lanier, Mark Santos, Yongsheng Chen, Maria Prat, Julio C. Castro-Palomino, John Saunders, Stacy Markison, John P. Williams, Emily Lin, Jaimie K. Rueter, Jose-Luis Diaz, María I. Crespo, Zhiyang Zuo, Manisha Moorjani, Deborah H. Slee, Raymond S. Gross, Xiaohu Zhang, Siobhan Malany
Publikováno v:
Journal of medicinal chemistry. 51(6)
Previously we have described a novel series of potent and selective A2A receptor antagonists (e.g., 1) with excellent aqueous solubility.(1) While these compounds are efficacious A2A antagonists in vivo, the presence of an unsubstituted furyl moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635873e0540ea30701b581ce36af9624
https://pubmed.ncbi.nlm.nih.gov/18307292
https://pubmed.ncbi.nlm.nih.gov/18307292
Autor:
Zhihong O’Brien, Marion Lanier, Silvia Gual, Siobhan Malany, Manisha Moorjani, John Saunders, Julio C. Castro-Palomino, María I. Crespo, Maria Prat, Sandra M. Lechner, John P. Williams, Deborah H. Slee, Jenny Wen, Xiaohu Zhang, Yongsheng Chen, Stacy Markison, Jose-Luis Diaz, Jaimie K. Rueter, Mark Santos, Emily Lin, Raymond S. Gross, Tanya Joswig
Publikováno v:
Journal of medicinal chemistry. 51(3)
Potent adenosine hA2A receptor antagonists are often accompanied by poor aqueous solubility, which presents issues for drug development. Herein we describe the early exploration of the structure-activity relationships of a lead pyrimidin-4-yl acetami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df191dacdb02a718b9d6e636b427da95
https://pubmed.ncbi.nlm.nih.gov/18189346
https://pubmed.ncbi.nlm.nih.gov/18189346
Autor:
Deborah H. Slee, Manisha Moorjani, Xiaohu Zhang, Emily Lin, Marion C. Lanier, Yongsheng Chen, Jaimie K. Rueter, Sandra M. Lechner, Stacy Markison, Siobhan Malany, Tanya Joswig, Mark Santos, Raymond S. Gross, John P. Williams, Julio C. Castro-Palomino, María I. Crespo, Maria Prat, Silvia Gual, José-Luis Díaz, Kayvon Jalali
Publikováno v:
Journal of Medicinal Chemistry; Feb2008, Vol. 51 Issue 6, p1730-1739, 10p
Autor:
Deborah H. Slee, Xiaohu Zhang, Manisha Moorjani, Emily Lin, Marion C. Lanier, Yongsheng Chen, Jaimie K. Rueter, Sandra M. Lechner, Stacy Markison, Siobhan Malany, Tanya Joswig, Mark Santos, Raymond S. Gross, John P. Williams, Julio C. Castro-Palomino, María I. Crespo, Maria Prat, Silvia Gual, José-Luis Díaz, Jenny Wen
Publikováno v:
Journal of Medicinal Chemistry; Jan2008, Vol. 51 Issue 3, p400-406, 7p