Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Silvia Grottelli"'
Autor:
Vinitha N. Ragavan, Pramod C. Nair, Natalia Jarzebska, Ramcharan Singh Angom, Luana Ruta, Elisa Bianconi, Silvia Grottelli, Natalia D. Tararova, Daniel Ryazanskiy, Steven R. Lentz, Sara Tommasi, Jens Martens-Lobenhoffer, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Elena Rubets, Sarah Chau, Yingjie Chen, Xinli Hu, Nadine Bernhardt, Peter M. Spieth, Norbert Weiss, Stefan R. Bornstein, Debabrata Mukhopadhyay, Stefanie M. Bode-Böger, Renke Maas, Ying Wang, Antonio Macchiarulo, Arduino A. Mangoni, Barbara Cellini, Roman N. Rodionov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects against cardiovascular disease by metabolising the risk factor asymmetric dimethylarginine (ADMA). However, the question whether the second DDAH isoform, DDAH2, directly metabolises
Externí odkaz:
https://doaj.org/article/c46891e5d10241cf95a530af2ca4d6b5
Autor:
Gioena Pampalone, Silvia Grottelli, Leonardo Gatticchi, Emilia Maria Lombardi, Ilaria Bellezza, Barbara Cellini
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 12, Pp 1627-1642 (2021)
Cells have evolved sophisticated molecular control systems to maximize the efficiency of the folding process. However, any subtle alteration of the environment or the protein can lead to misfolding or affect the conformational plasticity of the nativ
Externí odkaz:
https://doaj.org/article/cd8523f059ca4a5f9a252158b78b65a2
Autor:
Irene Valenti, Francesco Tini, Milos Sevarika, Alessandro Agazzi, Giovanni Beccari, Ilaria Bellezza, Luisa Ederli, Silvia Grottelli, Matias Pasquali, Roberto Romani, Marco Saracchi, Lorenzo Covarelli
Publikováno v:
Toxins, Vol 15, Iss 4, p 271 (2023)
Fusarium mycotoxins commonly contaminate agricultural products resulting in a serious threat to both animal and human health. The co-occurrence of different mycotoxins in the same cereal field is very common, so the risks as well as the functional an
Externí odkaz:
https://doaj.org/article/e7b5490bae244b158be2c1b8c92fb9ac
Autor:
Riccardo Montioli, Giada Sgaravizzi, Maria Andrea Desbats, Silvia Grottelli, Carla Borri Voltattorni, Leonardo Salviati, Barbara Cellini
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The deficit of human ornithine aminotransferase (hOAT) is responsible for gyrate atrophy (GA), a rare recessive inherited disorder. Although more than 60 disease-associated mutations have been identified to date, the molecular mechanisms explaining h
Externí odkaz:
https://doaj.org/article/2109747d33d04b62ae4d1dfbc902372e
Autor:
Silvia Grottelli, Rosa Amoroso, Lara Macchioni, Fiorella D’Onofrio, Katia Fettucciari, Ilaria Bellezza, Cristina Maccallini
Publikováno v:
Molecules, Vol 25, Iss 11, p 2646 (2020)
Neurodegenerative diseases are associated with increased levels of nitric oxide (NO) mainly produced by microglial cells through inducible nitric oxide synthase (iNOS) whose expression is induced by inflammatory stimuli. NO can both exert cytotoxic f
Externí odkaz:
https://doaj.org/article/716c0a82092049559cc6a4d97fe2742f
Autor:
Eva Pigna, Emanuela Greco, Giulio Morozzi, Silvia Grottelli, Alessio Rotini, Alba Minelli, Stefania Fulle, Sergio Adamo, Rosa Mancinelli, Ilaria Bellezza, Viviana Moresi
Publikováno v:
European Journal of Translational Myology, Vol 27, Iss 1 (2017)
Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness. Furthermore, denervation induces oxidative stress in skeletal muscle, which is thought t
Externí odkaz:
https://doaj.org/article/eb3af4132b284611b7143ea13c2d511a
Autor:
Silvia Grottelli, Ilaria Ferrari, Grazia Pietrini, Matthew J. Peirce, Alba Minelli, Ilaria Bellezza
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 8, p 1332 (2016)
Neurodegenerative diseases may have distinct genetic etiologies and pathological manifestations, yet share common cellular mechanisms underpinning neuronal damage and dysfunction. These cellular mechanisms include excitotoxicity, calcium dysregulatio
Externí odkaz:
https://doaj.org/article/c9c7d1eb5db743b8a558fa87391d38d8
Autor:
Silvia Grottelli, Giannamaria Annunziato, Gioena Pampalone, Marco Pieroni, Mirco Dindo, Francesca Ferlenghi, Gabriele Costantino, Barbara Cellini
Publikováno v:
Journal of medicinal chemistry. 65(14)
Primary hyperoxaluria type I (PH1) is a rare kidney disease due to the deficit of alanine:glyoxylate aminotransferase (AGT), a pyridoxal-5'-phosphate-dependent enzyme responsible for liver glyoxylate detoxification, which in turn prevents oxalate for
Autor:
Leonardo Gatticchi, Silvia Grottelli, Giulia Ambrosini, Gioena Pampalone, Ottavia Gualtieri, Ilaria Dando, Ilaria Bellezza, Barbara Cellini
Publikováno v:
Biochimie. 202
AGXT1 encodes alanine:glyoxylate aminotransferase 1 (AGT1), a liver peroxisomal pyridoxal 5'-phosphate dependent-enzyme whose deficit causes Primary Hyperoxaluria Type 1 (PH1). PH1 is a rare disease characterized by overproduction of oxalate, first l
Autor:
Giorgio Giardina, Davide Chiasserini, Mirco Dindo, Stefano Pascarelli, Silvia Grottelli, Paola Laurino, Gen-Ichiro Uechi, Claudio Costantini, Barbara Cellini
Genetic variations expand the conformational landscape of proteins and may underlie cryptic functions able to influence protein adaptability under unfavorable conditions. Cryptic functions usually associate with regions of increased frustration or ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b51eebaea674d285452c8166a1c71ca6
https://doi.org/10.1101/2021.05.24.445519
https://doi.org/10.1101/2021.05.24.445519